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On the one hand, robust, acute, and resolving type I IFN responses have been shown to mediate prominent anticancer effects, reflecting not only their direct cytostatic\/cytotoxic activity on (at least some) malignant cells, but also their pronounced immunostimulatory functions. In line with this notion, type I IFN signaling has been implicated in the antineoplastic effects of various immunogenic therapeutics, including (but not limited to) immunogenic cell death (ICD)\u2010inducing agents and immune checkpoint inhibitors (ICIs). On the other hand, weak, indolent, and non\u2010resolving type I IFN responses have been demonstrated to support tumor progression and resistance to therapy, reflecting the ability of suboptimal type I IFN signaling to mediate cytoprotective activity, promote stemness, favor tolerance to chromosomal instability, and facilitate the establishment of an immunologically exhausted tumor microenvironment. Here, we review fundamental aspects of type I IFN signaling and their context\u2010dependent impact on malignant transformation, tumor progression, and response to therapy.<\/jats:p>","DOI":"10.1111\/imr.13272","type":"journal-article","created":{"date-parts":[[2023,9,5]],"date-time":"2023-09-05T01:21:15Z","timestamp":1693876875000},"page":"115-127","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":143,"title":["Type I interferon and cancer"],"prefix":"10.1111","volume":"321","author":[{"given":"Peter","family":"Holicek","sequence":"first","affiliation":[{"name":"Sotio Biotech  Prague Czech Republic"},{"name":"Department of Immunology Charles University, 2nd Faculty of Medicine and University Hospital Motol  Prague Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emma","family":"Guilbaud","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Weill Cornell Medical College  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