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A number of studies have performed molecular characterization of these different microglial activation states over the last years making use of \u201comics\u201d technologies, that is transcriptomics, proteomics and, less frequently, epigenomics profiling. These approaches offer the possibility to identify disease mechanisms, discover novel diagnostic biomarkers, and develop new therapeutic strategies. Here, we focus on epigenetic profiling as a means to understand microglial immune responses beyond what other omics methods can offer, that is, revealing past and present molecular responses, gene regulatory networks and potential future response trajectories, and defining cell subtype\u2010specific disease relevance through mapping non\u2010coding genetic variants. 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