{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T22:51:14Z","timestamp":1791240674898,"version":"4.1.0"},"reference-count":98,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,4,17]],"date-time":"2024-04-17T00:00:00Z","timestamp":1713312000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006492","name":"Division of Intramural Research","doi-asserted-by":"publisher","award":["AI130043"],"award-info":[{"award-number":["AI130043"]}],"id":[{"id":"10.13039\/100006492","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006492","name":"Division of Intramural Research","doi-asserted-by":"publisher","award":["AI155558"],"award-info":[{"award-number":["AI155558"]}],"id":[{"id":"10.13039\/100006492","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006492","name":"Division of Intramural Research","doi-asserted-by":"publisher","award":["AI100874"],"award-info":[{"award-number":["AI100874"]}],"id":[{"id":"10.13039\/100006492","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006492","name":"Division of Intramural Research","doi-asserted-by":"publisher","award":["P30CA008748"],"award-info":[{"award-number":["P30CA008748"]}],"id":[{"id":"10.13039\/100006492","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000884","name":"Cancer Research Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000884","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000048","name":"American Cancer Society","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000048","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100014547","name":"Parker Institute for Cancer Immunotherapy","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100014547","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000861","name":"Burroughs Wellcome Fund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000861","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Immunological Reviews"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Cells of the mammalian innate immune system have evolved to protect the host from various environmental or internal insults and injuries which perturb the homeostatic state of the organism. Among the lymphocytes of the innate immune system are natural killer (NK) cells, which circulate and survey host tissues for signs of stress, including infection or transformation. NK cells rapidly eliminate damaged cells in the blood or within tissues through secretion of cytolytic machinery and production of proinflammatory cytokines. To perform these effector functions while traversing between the blood and tissues, patrolling NK cells require sufficient fuel to meet their energetic demands. Here, we highlight the ability of NK cells to metabolically adapt across tissues, during times of nutrient deprivation and within tumor microenvironments. Whether at steady state, or during viral infection and cancer, NK cells readily shift their nutrient uptake and usage in order to maintain metabolism, survival, and function.<\/jats:p>","DOI":"10.1111\/imr.13333","type":"journal-article","created":{"date-parts":[[2024,4,17]],"date-time":"2024-04-17T07:31:39Z","timestamp":1713339099000},"page":"8-18","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Metabolic programming of organ\u2010specific natural killer cell responses"],"prefix":"10.1111","volume":"323","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3066-4014","authenticated-orcid":false,"given":"Rebecca B.","family":"Delconte","sequence":"first","affiliation":[{"name":"Immunology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8062-9033","authenticated-orcid":false,"given":"Joseph C.","family":"Sun","sequence":"additional","affiliation":[{"name":"Immunology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center New York New York USA"},{"name":"Department of Immunology and Microbial Pathogenesis Weill Cornell Medical College New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,4,17]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aaw2586"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI200319246"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI20514"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI200319451"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-019-1325-x"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.02569"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.17306\/J.AFS.2014.2.8"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2018.04.022"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2019.07.049"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2019.07.050"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2019.07.047"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-immunol-101819-074948"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni1581"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.23.021704.115526"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41568-022-00491-0"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2012.87"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.2008-0165"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1158\/2326-6066.CIR-18-0500"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2015.08.016"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-022-01058-z"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2016.03.007"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.abi8642"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-021-01013-0"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.01659"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2021.08.002"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2023.08.004"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2023.11.018"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.3809"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.3800"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2021.03.023"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1402099"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.4161\/15384101.2014.972919"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1300090"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-07-297101"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni1523"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.2936"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2008-10-187179"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2007.06.016"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature08097"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1126\/scisignal.2005326"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc3483"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2021.109210"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2015.07.012"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.3838"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1158\/2159-8290.CD-15-0507"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-023-01620-z"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-04719-2"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1401558"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2319254121"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2018.06.002"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2016.08.011"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.1158\/2326-6066.CIR-18-0481"},{"key":"e_1_2_9_54_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1202702"},{"key":"e_1_2_9_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2023.05.011"},{"key":"e_1_2_9_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2018.01.004"},{"key":"e_1_2_9_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2020.05.001"},{"key":"e_1_2_9_58_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-17-2826"},{"key":"e_1_2_9_59_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.01989"},{"key":"e_1_2_9_60_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.02915"},{"key":"e_1_2_9_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2022.01.004"},{"key":"e_1_2_9_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2014.05.014"},{"key":"e_1_2_9_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2021.03.007"},{"key":"e_1_2_9_64_1","doi-asserted-by":"publisher","DOI":"10.1038\/s43587-020-00013-3"},{"key":"e_1_2_9_65_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00108.2002"},{"key":"e_1_2_9_66_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPA.0000000000000772"},{"key":"e_1_2_9_67_1","doi-asserted-by":"publisher","DOI":"10.1177\/0023677213501659"},{"key":"e_1_2_9_68_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2016.12.022"},{"key":"e_1_2_9_69_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2014.04.014"},{"key":"e_1_2_9_70_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2010.09.005"},{"key":"e_1_2_9_71_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2023.08.004"},{"key":"e_1_2_9_72_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0072449"},{"key":"e_1_2_9_73_1","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.R059543"},{"key":"e_1_2_9_74_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2022.862458"},{"key":"e_1_2_9_75_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature22352"},{"key":"e_1_2_9_76_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-022-05128-8"},{"key":"e_1_2_9_77_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2016.06.005"},{"key":"e_1_2_9_78_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2023.01.024"},{"key":"e_1_2_9_79_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.3688"},{"key":"e_1_2_9_80_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3003293"},{"key":"e_1_2_9_81_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trecan.2022.12.006"},{"key":"e_1_2_9_82_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2022.05.046"},{"key":"e_1_2_9_83_1","doi-asserted-by":"publisher","DOI":"10.1158\/2159-8290.CD-21-0030"},{"key":"e_1_2_9_84_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-018-0176-1"},{"key":"e_1_2_9_85_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-immunol-042617-053019"},{"key":"e_1_2_9_86_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.03706"},{"key":"e_1_2_9_87_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.3025"},{"key":"e_1_2_9_88_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.immuni.2024.05.021","article-title":"Fasting reshapes tissue\u2010specific niches to improve the innate immune response to cancer","author":"Delconte RB","year":"2024","journal-title":"Immunity"},{"key":"e_1_2_9_89_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2019.12.089"},{"key":"e_1_2_9_90_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2018.01.016"},{"key":"e_1_2_9_91_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12986-016-0159-x"},{"key":"e_1_2_9_92_1","doi-asserted-by":"publisher","DOI":"10.1038\/nutd.2014.10"},{"key":"e_1_2_9_93_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2017.01.008"},{"key":"e_1_2_9_94_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2016.03.002"},{"key":"e_1_2_9_95_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.3120"},{"key":"e_1_2_9_96_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2016.06.016"},{"key":"e_1_2_9_97_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2020.02.051"},{"key":"e_1_2_9_98_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0130357"},{"key":"e_1_2_9_99_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.1710"}],"container-title":["Immunological Reviews"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/imr.13333","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,16]],"date-time":"2024-11-16T11:32:09Z","timestamp":1731756729000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/imr.13333"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4,17]]},"references-count":98,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2024,5]]}},"alternative-id":["10.1111\/imr.13333"],"URL":"https:\/\/doi.org\/10.1111\/imr.13333","archive":["Portico"],"relation":{},"ISSN":["0105-2896","1600-065X"],"issn-type":[{"value":"0105-2896","type":"print"},{"value":"1600-065X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,4,17]]},"assertion":[{"value":"2024-04-17","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}