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We have shown that B cells modulate cardiometabolic disease through activities in two of these key adipose depots: visceral adipose tissue (VAT) and perivascular adipose tissue (PVAT). VAT refers to the adipose tissue surrounding organs, within the abdomen and thorax, and is comprised predominantly of white adipocytes. This depot has been implicated in mediating obesity\u2010related dysmetabolism. PVAT refers to adipose tissue surrounding major arteries. It had long been thought to exist to provide protection and insulation for the vessel, yet recent work demonstrates an important role for PVAT in harboring immune cells, promoting their function and regulating the biology of the underlying vessel. The role of B\u20102 cells and adaptive immunity in adipose tissue biology has been nicely reviewed elsewhere. Given that, the predominance of B\u20101 cells in adipose tissue at homeostasis, and the emerging role of B\u20101 cells in a variety of disease states, we will focus this review on how B\u20101 cells function in VAT and PVAT depots to promote homeostasis and limit inflammation linked to cardiometabolic disease and factors that regulate this function.<\/jats:p>","DOI":"10.1111\/imr.13342","type":"journal-article","created":{"date-parts":[[2024,5,15]],"date-time":"2024-05-15T11:26:19Z","timestamp":1715772379000},"page":"95-103","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["B\u20101 lymphocytes in adipose tissue as innate modulators of inflammation linked to cardiometabolic disease"],"prefix":"10.1111","volume":"324","author":[{"given":"Akshaya K.","family":"Meher","sequence":"first","affiliation":[{"name":"Department of Microbiology and Immunology, Brody School of Medicine East Carolina University  Greenville North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0049-9986","authenticated-orcid":false,"given":"Coleen A.","family":"McNamara","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine, Department of Medicine University of Virginia  Charlottesville Virginia USA"},{"name":"Beirne B. 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