{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T17:47:44Z","timestamp":1793296064260,"version":"4.5.0"},"reference-count":181,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,6,12]],"date-time":"2025-06-12T00:00:00Z","timestamp":1749686400000},"content-version":"am","delay-in-days":365,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#am"},{"start":{"date-parts":[[2024,6,12]],"date-time":"2024-06-12T00:00:00Z","timestamp":1718150400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["AI 175262"],"award-info":[{"award-number":["AI 175262"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000090","name":"Congressionally Directed Medical Research Programs","doi-asserted-by":"publisher","award":["W81XWH\u201010\u20101\u20100257"],"award-info":[{"award-number":["W81XWH\u201010\u20101\u20100257"]}],"id":[{"id":"10.13039\/100000090","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000090","name":"Congressionally Directed Medical Research Programs","doi-asserted-by":"publisher","award":["W81XWH\u201015\u20101\u20100213"],"award-info":[{"award-number":["W81XWH\u201015\u20101\u20100213"]}],"id":[{"id":"10.13039\/100000090","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007048","name":"Mayo Foundation for Medical Education and Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007048","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000069","name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","doi-asserted-by":"publisher","award":["AR30752"],"award-info":[{"award-number":["AR30752"]}],"id":[{"id":"10.13039\/100000069","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Immunological Reviews"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Rheumatoid arthritis (RA) is considered a multifactorial condition where interaction between the genetic and environmental factors lead to immune dysregulation causing autoreactivity. While among the various genetic factors, HLA\u2010DR4 and DQ8, have been reported to be the strongest risk factors, the role of various environmental factors has been unclear. Though events initiating autoreactivity remain unknown, a mucosal origin of RA has gained attention based on the recent observations with the gut dysbiosis in patients. However, causality of gut dysbiosis has been difficult to prove in humans. Mouse models, especially mice expressing RA\u2010susceptible and \u2010resistant HLA class II genes have helped unravel the complex interactions between genetic factors and gut microbiome. This review describes the interactions between HLA genes and gut dysbiosis in sex\u2010biased preclinical autoreactivity and discusses the potential use of endogenous commensals as indicators of treatment efficacy as well as therapeutic tool to suppress pro\u2010inflammatory response in rheumatoid arthritis.<\/jats:p>","DOI":"10.1111\/imr.13359","type":"journal-article","created":{"date-parts":[[2024,6,13]],"date-time":"2024-06-13T05:05:41Z","timestamp":1718255141000},"page":"90-106","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Gut microbiota as a sensor of autoimmune response and treatment for rheumatoid arthritis"],"prefix":"10.1111","volume":"325","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7173-9916","authenticated-orcid":false,"given":"Abhinav","family":"Lamba","sequence":"first","affiliation":[{"name":"University of Minnesota Medical School Minneapolis Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2401-694X","authenticated-orcid":false,"given":"Veena","family":"Taneja","sequence":"additional","affiliation":[{"name":"Department of Immunology and Division of Rheumatology Mayo Clinic College of Medicine Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,6,12]]},"reference":[{"key":"e_1_2_17_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2011.11.003"},{"key":"e_1_2_17_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2014.06.060"},{"key":"e_1_2_17_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2009.12.003"},{"key":"e_1_2_17_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncprheum0249"},{"key":"e_1_2_17_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature05911"},{"key":"e_1_2_17_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0065-2776(08)00002-3"},{"key":"e_1_2_17_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clim.2014.02.002"},{"key":"e_1_2_17_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrrheum.2012.134"},{"key":"e_1_2_17_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-023-06708-y"},{"key":"e_1_2_17_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2017.02.006"},{"key":"e_1_2_17_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri.2016.124"},{"key":"e_1_2_17_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780361009"},{"issue":"2","key":"e_1_2_17_14_1","first-page":"253","article-title":"Immunogenetics of familial rheumatoid arthritis: a study of 41 multicase families","volume":"20","author":"Taneja V","year":"1993","journal-title":"J Rheumatol"},{"key":"e_1_2_17_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2249.1991.tb05778.x"},{"key":"e_1_2_17_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/0198-8859(95)00165-4"},{"key":"e_1_2_17_17_1","first-page":"16","article-title":"Protective & risk DR phenotypes in Asian Indian patients with rheumatoid arthritis","volume":"96","author":"Taneja V","year":"1992","journal-title":"Indian J Med Res"},{"key":"e_1_2_17_18_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2020-219065"},{"key":"e_1_2_17_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.1076"},{"key":"e_1_2_17_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.582"},{"key":"e_1_2_17_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2009.12.007"},{"key":"e_1_2_17_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.3914"},{"key":"e_1_2_17_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41588-022-01213-w"},{"key":"e_1_2_17_24_1","first-page":"216","article-title":"Restriction fragment length polymorphisms in HLA\u2010DR4\u2010DQ3 haplotypes associated with rheumatoid arthritis","volume":"99","author":"Taneja V","year":"1994","journal-title":"Indian J Med Res"},{"key":"e_1_2_17_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.febslet.2014.05.034"},{"key":"e_1_2_17_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2009.10.006"},{"key":"e_1_2_17_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12016-009-8158-6"},{"issue":"1","key":"e_1_2_17_28_1","first-page":"70","article-title":"Association of periodontal disease and tooth loss with rheumatoid arthritis in the US population","volume":"35","author":"Pablo P","year":"2008","journal-title":"J Rheumatol"},{"key":"e_1_2_17_29_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keq088"},{"key":"e_1_2_17_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1574-695X.2010.00657.x"},{"key":"e_1_2_17_31_1","doi-asserted-by":"publisher","DOI":"10.1097\/BOR.0b013e3283477b7b"},{"key":"e_1_2_17_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2011.03.004"},{"key":"e_1_2_17_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2009.10.004"},{"key":"e_1_2_17_34_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.01931"},{"key":"e_1_2_17_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/bs.vh.2020.12.015"},{"key":"e_1_2_17_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2014.11.028"},{"key":"e_1_2_17_37_1","doi-asserted-by":"publisher","DOI":"10.1111\/imm.12474"},{"key":"e_1_2_17_38_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.181.4.2869"},{"key":"e_1_2_17_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0198-8859(00)00208-1"},{"key":"e_1_2_17_40_1","doi-asserted-by":"publisher","DOI":"10.1186\/ar88"},{"key":"e_1_2_17_41_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0036095"},{"key":"e_1_2_17_42_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrrheum.2011.121"},{"key":"e_1_2_17_43_1","doi-asserted-by":"publisher","DOI":"10.1186\/1479-5876-6-48"},{"key":"e_1_2_17_44_1","doi-asserted-by":"publisher","DOI":"10.3390\/medicina56090462"},{"key":"e_1_2_17_45_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.174.12.8116"},{"key":"e_1_2_17_46_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.896476"},{"key":"e_1_2_17_47_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.321.7276.1586"},{"key":"e_1_2_17_48_1","doi-asserted-by":"publisher","DOI":"10.3390\/plants11101334"},{"key":"e_1_2_17_49_1","doi-asserted-by":"publisher","DOI":"10.1353\/bhm.1998.0056"},{"key":"e_1_2_17_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.micinf.2008.08.012"},{"key":"e_1_2_17_51_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12866-016-0708-5"},{"key":"e_1_2_17_52_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1104816"},{"key":"e_1_2_17_53_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12915-017-0454-7"},{"key":"e_1_2_17_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.isci.2022.104477"},{"key":"e_1_2_17_55_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro.2016.142"},{"key":"e_1_2_17_56_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1000081107"},{"key":"e_1_2_17_57_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-022-05620-1"},{"key":"e_1_2_17_58_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature06244"},{"key":"e_1_2_17_59_1","doi-asserted-by":"publisher","DOI":"10.1038\/msb.2013.22"},{"key":"e_1_2_17_60_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri1373"},{"key":"e_1_2_17_61_1","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.M002774"},{"key":"e_1_2_17_62_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.nutr.22.011602.092259"},{"key":"e_1_2_17_63_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri2515"},{"key":"e_1_2_17_64_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3000322"},{"key":"e_1_2_17_65_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro2974"},{"key":"e_1_2_17_66_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.2640"},{"key":"e_1_2_17_67_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.2604"},{"key":"e_1_2_17_68_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature09944"},{"key":"e_1_2_17_69_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2019.01.004"},{"key":"e_1_2_17_70_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2009.174136"},{"key":"e_1_2_17_71_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature11053"},{"key":"e_1_2_17_72_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41575-022-00605-x"},{"key":"e_1_2_17_73_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0090731"},{"key":"e_1_2_17_74_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-61192-y"},{"key":"e_1_2_17_75_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aat7164"},{"key":"e_1_2_17_76_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00726-010-0556-9"},{"key":"e_1_2_17_77_1","doi-asserted-by":"publisher","DOI":"10.1038\/ijo.2008.155"},{"key":"e_1_2_17_78_1","doi-asserted-by":"publisher","DOI":"10.1111\/1541-4337.12401"},{"key":"e_1_2_17_79_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00726-014-1807-y"},{"key":"e_1_2_17_80_1","doi-asserted-by":"publisher","DOI":"10.3945\/jn.108.103267"},{"issue":"3","key":"e_1_2_17_81_1","first-page":"391","article-title":"Gene, environment, microbiome and mucosal immune tolerance in rheumatoid arthritis","volume":"55","author":"Catrina AI","year":"2016","journal-title":"Rheumatology (Oxford)"},{"key":"e_1_2_17_82_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13073-016-0299-7"},{"key":"e_1_2_17_83_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.01202"},{"key":"e_1_2_17_84_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13073-021-00957-0"},{"key":"e_1_2_17_85_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrrheum.2016.222"},{"key":"e_1_2_17_86_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra020100"},{"key":"e_1_2_17_87_1","doi-asserted-by":"publisher","DOI":"10.1080\/17474124.2018.1517044"},{"key":"e_1_2_17_88_1","first-page":"1","article-title":"The role of microbiome in rheumatoid arthritis treatment","volume":"11","author":"Bodkhe R","year":"2019","journal-title":"Therapeut Adv Musculoskelet Dis"},{"key":"e_1_2_17_89_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.68.10.6012-6026.2000"},{"issue":"8","key":"e_1_2_17_90_1","first-page":"1500","article-title":"Fecal microbiota in early rheumatoid arthritis","volume":"35","author":"Vaahtovuo J","year":"2008","journal-title":"J Rheumatol"},{"key":"e_1_2_17_91_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.adg1129"},{"key":"e_1_2_17_92_1","doi-asserted-by":"publisher","DOI":"10.3390\/microorganisms10091820"},{"key":"e_1_2_17_93_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard-2022-222871"},{"key":"e_1_2_17_94_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-33576-3"},{"key":"e_1_2_17_95_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.59.11.841"},{"key":"e_1_2_17_96_1","doi-asserted-by":"publisher","DOI":"10.1093\/milmed\/usy309"},{"key":"e_1_2_17_97_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0105-2896.2009.00858.x"},{"key":"e_1_2_17_98_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.40490"},{"key":"e_1_2_17_99_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep30594"},{"key":"e_1_2_17_100_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.40003"},{"key":"e_1_2_17_101_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.42370"},{"key":"e_1_2_17_102_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard-2022-222881"},{"key":"e_1_2_17_103_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.34595"},{"key":"e_1_2_17_104_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.27552"},{"key":"e_1_2_17_105_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12102"},{"key":"e_1_2_17_106_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41584-018-0070-0"},{"key":"e_1_2_17_107_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2015.10.024"},{"key":"e_1_2_17_108_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.163.3.1661"},{"key":"e_1_2_17_109_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.39783"},{"key":"e_1_2_17_110_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.abn5166"},{"key":"e_1_2_17_111_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0162341"},{"key":"e_1_2_17_112_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0059260"},{"key":"e_1_2_17_113_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40168-016-0206-x"},{"key":"e_1_2_17_114_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clim.2021.108813"},{"key":"e_1_2_17_115_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.22213"},{"key":"e_1_2_17_116_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-020-00816-x"},{"key":"e_1_2_17_117_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.smim.2023.101814"},{"key":"e_1_2_17_118_1","doi-asserted-by":"publisher","DOI":"10.3233\/NHA-170030"},{"key":"e_1_2_17_119_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellimm.2018.10.005"},{"key":"e_1_2_17_120_1","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1433.065"},{"key":"e_1_2_17_121_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2011.12.005"},{"key":"e_1_2_17_122_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.39785"},{"key":"e_1_2_17_123_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2022017514"},{"key":"e_1_2_17_124_1","doi-asserted-by":"publisher","DOI":"10.1038\/s43587-021-00093-9"},{"key":"e_1_2_17_125_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2017.01385"},{"key":"e_1_2_17_126_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40168-014-0050-9"},{"key":"e_1_2_17_127_1","doi-asserted-by":"publisher","DOI":"10.1159\/000490615"},{"key":"e_1_2_17_128_1","doi-asserted-by":"publisher","DOI":"10.1111\/acel.13240"},{"key":"e_1_2_17_129_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1515386112"},{"key":"e_1_2_17_130_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2018.03.006"},{"key":"e_1_2_17_131_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2020.07.013"},{"key":"e_1_2_17_132_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2016.05.006"},{"key":"e_1_2_17_133_1","doi-asserted-by":"publisher","DOI":"10.3945\/jn.114.200626"},{"key":"e_1_2_17_134_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2017.01632"},{"key":"e_1_2_17_135_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tem.2012.06.005"},{"key":"e_1_2_17_136_1","doi-asserted-by":"publisher","DOI":"10.14348\/molcells.2016.2318"},{"key":"e_1_2_17_137_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.xcrm.2023.101157"},{"key":"e_1_2_17_138_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.779177"},{"key":"e_1_2_17_139_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-18305-x"},{"key":"e_1_2_17_140_1","doi-asserted-by":"publisher","DOI":"10.1177\/1535370214538743"},{"key":"e_1_2_17_141_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2022.796850"},{"key":"e_1_2_17_142_1","doi-asserted-by":"publisher","DOI":"10.1038\/cddiscovery.2017.75"},{"key":"e_1_2_17_143_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-14421-x"},{"key":"e_1_2_17_144_1","doi-asserted-by":"publisher","DOI":"10.1264\/jsme2.ME17017"},{"key":"e_1_2_17_145_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0124599"},{"key":"e_1_2_17_146_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1208344"},{"key":"e_1_2_17_147_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11357-019-00149-0"},{"key":"e_1_2_17_148_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2016-210431"},{"key":"e_1_2_17_149_1","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.114.086918"},{"key":"e_1_2_17_150_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2015.10.001"},{"key":"e_1_2_17_151_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.609644"},{"key":"e_1_2_17_152_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnut.2017.00052"},{"key":"e_1_2_17_153_1","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.02340-06"},{"key":"e_1_2_17_154_1","doi-asserted-by":"publisher","DOI":"10.1890\/09-0235.1"},{"issue":"2","key":"e_1_2_17_155_1","first-page":"214","article-title":"The influence of sex on rheumatoid arthritis: a prospective study of onset and outcome after 2\u2009years","volume":"31","author":"Tengstrand B","year":"2004","journal-title":"J Rheumatol"},{"issue":"1","key":"e_1_2_17_156_1","doi-asserted-by":"crossref","first-page":"R7","DOI":"10.1186\/ar2591","article-title":"Women, men, and rheumatoid arthritis: analyses of disease activity, disease characteristics, and treatments in the QUEST\u2010RA study","volume":"11","author":"Sokka T","year":"2009","journal-title":"Arthritis Res Ther"},{"key":"e_1_2_17_157_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2008.102244"},{"key":"e_1_2_17_158_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2009.01.005"},{"issue":"11","key":"e_1_2_17_159_1","first-page":"2338","article-title":"Abnormal levels of serum dehydroepiandrosterone, estrone, and estradiol in men with rheumatoid arthritis: high correlation between serum estradiol and current degree of inflammation","volume":"30","author":"Tengstrand B","year":"2003","journal-title":"J Rheumatol"},{"key":"e_1_2_17_160_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri2394"},{"key":"e_1_2_17_161_1","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/928290"},{"key":"e_1_2_17_162_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI0214873"},{"key":"e_1_2_17_163_1","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.M038869"},{"key":"e_1_2_17_164_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-4731(84)90208-5"},{"key":"e_1_2_17_165_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro1836"},{"key":"e_1_2_17_166_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.maturitas.2018.07.008"},{"key":"e_1_2_17_167_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0010-7824(98)00044-4"},{"key":"e_1_2_17_168_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2019-215743"},{"key":"e_1_2_17_169_1","doi-asserted-by":"publisher","DOI":"10.1186\/1742-4933-10-19"},{"key":"e_1_2_17_170_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0320(19960315)26:1<8::AID-CYTO2>3.0.CO;2-E"},{"key":"e_1_2_17_171_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jri.2006.01.004"},{"key":"e_1_2_17_172_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1233521"},{"key":"e_1_2_17_173_1","doi-asserted-by":"publisher","DOI":"10.2147\/CLEP.S229056"},{"key":"e_1_2_17_174_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri2815"},{"key":"e_1_2_17_175_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clim.2015.04.016"},{"key":"e_1_2_17_176_1","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.72.2.1027-1033.2006"},{"key":"e_1_2_17_177_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature25979"},{"key":"e_1_2_17_178_1","doi-asserted-by":"publisher","DOI":"10.1002\/jps.24103"},{"key":"e_1_2_17_179_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.41622"},{"key":"e_1_2_17_180_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.abm1511"},{"key":"e_1_2_17_181_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2020.03.003"},{"key":"e_1_2_17_182_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.204.Supp.141.17"}],"container-title":["Immunological Reviews"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/am-pdf\/10.1111\/imr.13359","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/imr.13359","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,21]],"date-time":"2024-11-21T18:53:23Z","timestamp":1732215203000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/imr.13359"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6,12]]},"references-count":181,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2024,8]]}},"alternative-id":["10.1111\/imr.13359"],"URL":"https:\/\/doi.org\/10.1111\/imr.13359","archive":["Portico"],"relation":{},"ISSN":["0105-2896","1600-065X"],"issn-type":[{"value":"0105-2896","type":"print"},{"value":"1600-065X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,6,12]]},"assertion":[{"value":"2024-06-12","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}