{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T19:31:29Z","timestamp":1787859089025,"version":"build-2784847793"},"reference-count":204,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,9,9]],"date-time":"2024-09-09T00:00:00Z","timestamp":1725840000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2024,9,9]],"date-time":"2024-09-09T00:00:00Z","timestamp":1725840000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Immunological Reviews"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>Systemic sclerosis (SSc) is a severe autoimmune disease characterized by vasculopathy, fibrosis, and dysregulated immunity, with hallmark autoantibodies targeting nuclear antigens such as centromere protein (ACA) and topoisomerase I (ATA). These autoantibodies are highly prevalent and disease\u2010specific, rarely coexisting, thus serving as crucial biomarkers for SSc diagnosis. Despite their diagnostic value, their roles in SSc pathogenesis remain unclear. This review summarizes current literature on ACA and ATA in SSc, comparing them to autoantibodies in other rheumatic diseases to elucidate their potential pathogenic roles. Similarities are drawn with anti\u2010citrullinated protein antibodies (ACPA) in rheumatoid arthritis, particularly regarding disease specificity and minimal pathogenic impact of antigen binding. In addition, differences between ANA and ACPA in therapeutic responses and Fab glycosylation patterns are reviewed. While ACA and ATA are valuable for disease stratification and monitoring activity, understanding their origins and the associated B cell responses is critical for advancing therapeutic strategies for SSc.<\/jats:p>","DOI":"10.1111\/imr.13390","type":"journal-article","created":{"date-parts":[[2024,9,9]],"date-time":"2024-09-09T06:07:57Z","timestamp":1725862077000},"page":"265-282","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Pathogenic role of anti\u2010nuclear autoantibodies in systemic sclerosis: Insights from other rheumatic diseases"],"prefix":"10.1111","volume":"328","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5619-4508","authenticated-orcid":false,"given":"Wieke M.","family":"van Oostveen","sequence":"first","affiliation":[{"name":"Department of Rheumatology Leiden University Medical Center  Leiden The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7033-7520","authenticated-orcid":false,"given":"Tom W. J.","family":"Huizinga","sequence":"additional","affiliation":[{"name":"Department of Rheumatology Leiden University Medical Center  Leiden The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9020-1591","authenticated-orcid":false,"given":"Cynthia M.","family":"Fehres","sequence":"additional","affiliation":[{"name":"Department of Rheumatology Leiden University Medical Center  Leiden The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,9,9]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2022.05.023"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard-2023-224692"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2020.102743"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(17)30933-9"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcp013013"},{"issue":"4","key":"e_1_2_9_7_1","first-page":"57","article-title":"Mechanics of early ventricular impairment in systemic sclerosis and the effects of peripheral arterial haemodynamics","volume":"37","author":"Tountas C","year":"2019","journal-title":"Clin Exp Rheumatol"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keaa911"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semarthrit.2022.152136"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.revmed.2016.02.016"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0214202"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1136\/rmdopen-2022-002827"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1136\/rmdopen-2023-003148"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semarthrit.2005.03.005"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1080\/08916934.2017.1357699"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.120283"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2012.05.011"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.biochem.70.1.369"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M114.635078"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkn1009"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(19)86738-8"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1165\/ajrcmb.22.3.3850"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1093\/intimm\/dxp008"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780361013"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780331007"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(199906)42:6<1179::AID-ANR14>3.0.CO;2-E"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/imm.12323"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2019-216499"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.175.4.1103"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI112320"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.116.3.585"},{"key":"e_1_2_9_32_1","first-page":"360","article-title":"CENP\u2010B is a highly conserved mammalian centromere protein with homology to the helix\u2010loop\u2010helix family of","volume":"100","author":"Sullivan KF","year":"1991","journal-title":"Proteins"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.136.3.487"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.104.4.817"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/34.5.407"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.84.14.4979"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1186\/ar3029"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.imlet.2020.02.005"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1007\/s001090100258"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2006.10.001"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1007\/s001090000128"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI14452"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41584-018-0145-y"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2019-215337"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-36257-x"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41423-020-0381-3"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard-2022-223417"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.42679"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.41403"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.3899\/JRHEUM.191331"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.41814"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-024-61159-3"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.revmed.2023.11.006"},{"key":"e_1_2_9_54_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2012-202297"},{"key":"e_1_2_9_55_1","doi-asserted-by":"publisher","DOI":"10.3390\/diagnostics12071773"},{"key":"e_1_2_9_56_1","doi-asserted-by":"publisher","DOI":"10.1136\/rmdopen-2017-000564"},{"key":"e_1_2_9_57_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0909905"},{"key":"e_1_2_9_58_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2016-209909"},{"key":"e_1_2_9_59_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2018.00163"},{"key":"e_1_2_9_60_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2019.243543"},{"key":"e_1_2_9_61_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.11181"},{"issue":"3","key":"e_1_2_9_62_1","first-page":"424","article-title":"Changes in anti\u2010cyclic citrullinated peptide antibodies and rheumatoid factor isotypes serum levels in patients with rheumatoid arthritis following treatment with different biological drugs","volume":"34","author":"Iannone F","year":"2016","journal-title":"Clin Exp Rheumatol"},{"key":"e_1_2_9_63_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13075-017-1306-0"},{"key":"e_1_2_9_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semarthrit.2014.09.002"},{"key":"e_1_2_9_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2665-9913(21)00107-7"},{"key":"e_1_2_9_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(23)01126-1"},{"key":"e_1_2_9_67_1","doi-asserted-by":"publisher","DOI":"10.1080\/21645515.2017.1316909"},{"key":"e_1_2_9_68_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41584-020-0419-z"},{"key":"e_1_2_9_69_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2008.105197"},{"key":"e_1_2_9_70_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.20303"},{"key":"e_1_2_9_71_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.10623"},{"key":"e_1_2_9_72_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keaa393"},{"key":"e_1_2_9_73_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.21650"},{"key":"e_1_2_9_74_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.27221"},{"key":"e_1_2_9_75_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.41668"},{"key":"e_1_2_9_76_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-2600(20)30318-0"},{"key":"e_1_2_9_77_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)00232-4"},{"key":"e_1_2_9_78_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrrheum.2017.7"},{"key":"e_1_2_9_79_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41409-019-0516-2"},{"key":"e_1_2_9_80_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)02627-1"},{"key":"e_1_2_9_81_1","doi-asserted-by":"publisher","DOI":"10.1191\/0961203304lu1027oa"},{"key":"e_1_2_9_82_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.295.5.527"},{"key":"e_1_2_9_83_1","first-page":"25","article-title":"Intensive immunosuppression and autologous stem cell transplantation for patients with severe rheumatoid arthritis: the Leiden experience","volume":"64","author":"Laar JM","year":"2001","journal-title":"J Rheumatol Suppl"},{"key":"e_1_2_9_84_1","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(200104)44:4<754::AID-ANR131>3.0.CO;2-N"},{"key":"e_1_2_9_85_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.10495"},{"key":"e_1_2_9_86_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keab257"},{"key":"e_1_2_9_87_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13075-019-1889-8"},{"key":"e_1_2_9_88_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13045-016-0388-5"},{"key":"e_1_2_9_89_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kew319"},{"key":"e_1_2_9_90_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard-2021-221926"},{"key":"e_1_2_9_91_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard-2021-221925"},{"key":"e_1_2_9_92_1","doi-asserted-by":"publisher","DOI":"10.1056\/nejmoa1708566"},{"key":"e_1_2_9_93_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41571-023-00754-1"},{"key":"e_1_2_9_94_1","doi-asserted-by":"publisher","DOI":"10.1186\/2162-3619-1-36"},{"key":"e_1_2_9_95_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMc2107725"},{"key":"e_1_2_9_96_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard-2023-223952"},{"key":"e_1_2_9_97_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard-2023-225174"},{"key":"e_1_2_9_98_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.44.2.89"},{"key":"e_1_2_9_99_1","doi-asserted-by":"publisher","DOI":"10.1056\/nejmoa2308917"},{"key":"e_1_2_9_100_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aaf6756"},{"key":"e_1_2_9_101_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.iy.11.040193.000455"},{"key":"e_1_2_9_102_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2015-208093"},{"key":"e_1_2_9_103_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2015-208094"},{"key":"e_1_2_9_104_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.40699"},{"key":"e_1_2_9_105_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2015-208093corr1"},{"key":"e_1_2_9_106_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2015-208094corr1"},{"key":"e_1_2_9_107_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20121486"},{"key":"e_1_2_9_108_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2249.2002.01888.x"},{"key":"e_1_2_9_109_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0028626"},{"issue":"11","key":"e_1_2_9_110_1","first-page":"2243","article-title":"Immunization with DNA topoisomerase I induces autoimmune responses but not scleroderma\u2010like pathologies in mice","volume":"34","author":"Hu PQ","year":"2007","journal-title":"J Rheumatol"},{"key":"e_1_2_9_111_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.30539"},{"key":"e_1_2_9_112_1","doi-asserted-by":"publisher","DOI":"10.1080\/08916934.2016.1230848"},{"key":"e_1_2_9_113_1","doi-asserted-by":"publisher","DOI":"10.1247\/csf.17.129"},{"key":"e_1_2_9_114_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.677970"},{"key":"e_1_2_9_115_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13075-022-02896-6"},{"key":"e_1_2_9_116_1","doi-asserted-by":"publisher","DOI":"10.1038\/s12276-022-00860-7"},{"key":"e_1_2_9_117_1","doi-asserted-by":"publisher","DOI":"10.1159\/000164015"},{"key":"e_1_2_9_118_1","doi-asserted-by":"publisher","DOI":"10.1006\/cimm.1996.0017"},{"key":"e_1_2_9_119_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.175.4.2418"},{"key":"e_1_2_9_120_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1747.1999.00528.x"},{"key":"e_1_2_9_121_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41581-023-00720-1"},{"key":"e_1_2_9_122_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI60975"},{"key":"e_1_2_9_123_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2010.135509"},{"key":"e_1_2_9_124_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.40698"},{"key":"e_1_2_9_125_1","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(200104)44:4<921::AID-ANR149>3.0.CO;2-4"},{"key":"e_1_2_9_126_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.20862"},{"key":"e_1_2_9_127_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncprheum0895"},{"key":"e_1_2_9_128_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI118851"},{"key":"e_1_2_9_129_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1996.tb26405.x"},{"key":"e_1_2_9_130_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.21646"},{"key":"e_1_2_9_131_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.20515"},{"key":"e_1_2_9_132_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.33377"},{"key":"e_1_2_9_133_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.33484"},{"key":"e_1_2_9_134_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13075-019-1931-x"},{"key":"e_1_2_9_135_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0803705"},{"key":"e_1_2_9_136_1","doi-asserted-by":"publisher","DOI":"10.31138\/MJR.31.1.50"},{"key":"e_1_2_9_137_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.24622"},{"key":"e_1_2_9_138_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2014-205562"},{"key":"e_1_2_9_139_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1402334"},{"key":"e_1_2_9_140_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrrheum.2016.186"},{"key":"e_1_2_9_141_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13075-018-1689-6"},{"key":"e_1_2_9_142_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13075-020-02360-3"},{"key":"e_1_2_9_143_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41577-021-00577-0"},{"key":"e_1_2_9_144_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.620972"},{"key":"e_1_2_9_145_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.23486"},{"key":"e_1_2_9_146_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2009.121400"},{"key":"e_1_2_9_147_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2021.102804"},{"key":"e_1_2_9_148_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.bi.41.070172.003325"},{"key":"e_1_2_9_149_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2010.04.012"},{"key":"e_1_2_9_150_1","doi-asserted-by":"publisher","DOI":"10.1093\/GLYCOB\/CWZ048"},{"key":"e_1_2_9_151_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41584-022-00867-4"},{"key":"e_1_2_9_152_1","doi-asserted-by":"publisher","DOI":"10.1021\/pr300887z"},{"key":"e_1_2_9_153_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2017.00646"},{"key":"e_1_2_9_154_1","doi-asserted-by":"publisher","DOI":"10.1038\/316452a0"},{"key":"e_1_2_9_155_1","doi-asserted-by":"publisher","DOI":"10.1006\/jaut.1996.0104"},{"key":"e_1_2_9_156_1","doi-asserted-by":"publisher","DOI":"10.1186\/ar2892"},{"key":"e_1_2_9_157_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13075-017-1367-0"},{"key":"e_1_2_9_158_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.advms.2015.12.009"},{"key":"e_1_2_9_159_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1214945"},{"key":"e_1_2_9_160_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2249.2002.01864.x"},{"key":"e_1_2_9_161_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1257906"},{"key":"e_1_2_9_162_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jim.2019.02.005"},{"key":"e_1_2_9_163_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsomega.9b04412"},{"key":"e_1_2_9_164_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms11205"},{"key":"e_1_2_9_165_1","doi-asserted-by":"publisher","DOI":"10.1080\/03009742.2019.1641615"},{"key":"e_1_2_9_166_1","unstructured":"YangS KimJY LeeEB SongSH.N\u2010glycosylation trait of anti\u2010centromere antibodies. Mass Spectrometry & Advances in the Clinical Lab.2023. Accessed July 4 2024https:\/\/www.msacl.org\/presenter_posters\/2023_65a_seojin.yang_5965315_poster.pdf"},{"key":"e_1_2_9_167_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2013-203565"},{"key":"e_1_2_9_168_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.27414"},{"key":"e_1_2_9_169_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0113924"},{"key":"e_1_2_9_170_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0213215"},{"key":"e_1_2_9_171_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.30362"},{"key":"e_1_2_9_172_1","doi-asserted-by":"publisher","DOI":"10.1021\/pr500780a"},{"key":"e_1_2_9_173_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2017.01.033"},{"key":"e_1_2_9_174_1","doi-asserted-by":"publisher","DOI":"10.1111\/cei.12744"},{"key":"e_1_2_9_175_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.38082"},{"key":"e_1_2_9_176_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0021246"},{"key":"e_1_2_9_177_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0037243"},{"key":"e_1_2_9_178_1","doi-asserted-by":"publisher","DOI":"10.1002\/pmic.200800931"},{"key":"e_1_2_9_179_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0808248105"},{"key":"e_1_2_9_180_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2022.103883"},{"key":"e_1_2_9_181_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1129594"},{"key":"e_1_2_9_182_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molimm.2006.09.005"},{"key":"e_1_2_9_183_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M202069200"},{"key":"e_1_2_9_184_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2017.00877"},{"key":"e_1_2_9_185_1","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0000000000000444"},{"key":"e_1_2_9_186_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1304365"},{"key":"e_1_2_9_187_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23105828"},{"key":"e_1_2_9_188_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1502136"},{"key":"e_1_2_9_189_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1711720115"},{"key":"e_1_2_9_190_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jim.2012.05.022"},{"key":"e_1_2_9_191_1","doi-asserted-by":"publisher","DOI":"10.1074\/mcp.M114.039537"},{"key":"e_1_2_9_192_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0161-5890(00)00038-9"},{"key":"e_1_2_9_193_1","doi-asserted-by":"publisher","DOI":"10.1093\/jb\/mvaa116"},{"key":"e_1_2_9_194_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2018.06.071"},{"key":"e_1_2_9_195_1","doi-asserted-by":"publisher","DOI":"10.1080\/19420862.2015.1112477"},{"key":"e_1_2_9_196_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.00740"},{"key":"e_1_2_9_197_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2014-206598"},{"key":"e_1_2_9_198_1","doi-asserted-by":"publisher","DOI":"10.1074\/mcp.M116.062919"},{"key":"e_1_2_9_199_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.42098"},{"key":"e_1_2_9_200_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.40920"},{"key":"e_1_2_9_201_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2172-13-10"},{"key":"e_1_2_9_202_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2022.10.035"},{"key":"e_1_2_9_203_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-024-47337-x"},{"key":"e_1_2_9_204_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.abm1759"},{"key":"e_1_2_9_205_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.02092"}],"container-title":["Immunological Reviews"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/imr.13390","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/imr.13390","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/imr.13390","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T13:42:22Z","timestamp":1786542142000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/imr.13390"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9,9]]},"references-count":204,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2024,11]]}},"alternative-id":["10.1111\/imr.13390"],"URL":"https:\/\/doi.org\/10.1111\/imr.13390","archive":["Portico"],"relation":{},"ISSN":["0105-2896","1600-065X"],"issn-type":[{"value":"0105-2896","type":"print"},{"value":"1600-065X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,9,9]]},"assertion":[{"value":"2024-09-09","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}