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The mechanisms of tolerance to dietary proteins have been extensively studied in mouse models but the extent to which the results in mice can be extrapolated to humans remains unclear. Here, after summarizing the mechanisms known to control oral tolerance in mouse models, we discuss how the monogenic immune disorders associated with food allergy on the one hand, and celiac disease, on the other hand, represent model diseases to gain insight into the key immunoregulatory pathways that control immune responses to food antigens in humans. The spectrum of monogenic disorders, in which the dysfunction of a single gene, is strongly associated with TH2\u2010mediated food allergy suggests an important overlap between the mechanisms that regulate TH2 and IgE responses to food antigens in humans and mice. In contrast, celiac disease provides a unique example of the link between autoimmunity and loss of tolerance to a food antigen.<\/jats:p>","DOI":"10.1111\/imr.13395","type":"journal-article","created":{"date-parts":[[2024,9,19]],"date-time":"2024-09-19T05:00:21Z","timestamp":1726722021000},"page":"173-190","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Loss of tolerance to dietary proteins: From mouse models to human model diseases"],"prefix":"10.1111","volume":"326","author":[{"given":"Anais","family":"Levescot","sequence":"first","affiliation":[{"name":"Laboratory of Intestinal Immunity, INSERM UMR 1163 and Imagine Institute Universit\u00e9 Paris Cit\u00e9  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0665-1245","authenticated-orcid":false,"given":"Nadine","family":"Cerf\u2010Bensussan","sequence":"additional","affiliation":[{"name":"Laboratory of Intestinal Immunity, INSERM UMR 1163 and Imagine Institute Universit\u00e9 Paris Cit\u00e9  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,9,18]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.smim.2017.07.004"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41577-018-0002-x"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/mi.2012.4"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2020.02.010"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2021-326257"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2024.03.042"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(17)31796-8"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2017.06.037"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2012.06.006"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2016.02.004"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2011.01.016"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.288.5474.2222"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3083.1985.tb01862.x"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.200324115"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aac5560"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-022-04916-6"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI24487"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2008.05.010"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.200425882"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20070590"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20052016"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aah5298"},{"key":"e_1_2_6_24_1","unstructured":"CanessoMC CastroTB Nakandakari\u2010HigaS et\u00a0al.Identification of Dendritic Cell\u2010T Cell Interactions Driving Immune Responses to Food.BioRxiv. 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