{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T02:35:32Z","timestamp":1793932532142,"version":"4.8.0"},"reference-count":162,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,10,29]],"date-time":"2024-10-29T00:00:00Z","timestamp":1730160000000},"content-version":"vor","delay-in-days":28,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["NS065745"],"award-info":[{"award-number":["NS065745"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["NS126452"],"award-info":[{"award-number":["NS126452"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["R01NS134651"],"award-info":[{"award-number":["R01NS134651"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["R01NS131480"],"award-info":[{"award-number":["R01NS131480"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["R21NS123477"],"award-info":[{"award-number":["R21NS123477"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["U01NS106845"],"award-info":[{"award-number":["U01NS106845"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["U54NS15052"],"award-info":[{"award-number":["U54NS15052"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100015326","name":"Common Fund","doi-asserted-by":"publisher","award":["DP5\u2010OD036159"],"award-info":[{"award-number":["DP5\u2010OD036159"]}],"id":[{"id":"10.13039\/100015326","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["AI143982"],"award-info":[{"award-number":["AI143982"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["R01AI139544"],"award-info":[{"award-number":["R01AI139544"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["Ideas Grant APP2001543"],"award-info":[{"award-number":["Ideas Grant APP2001543"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Immunological Reviews"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>Aicardi\u2010Gouti\u00e8res syndrome (AGS) is a progressive genetic encephalopathy caused by pathogenic mutations in genes controlling cellular anti\u2010viral responses and nucleic acid metabolism. The mutations initiate autoinflammatory processes in the brain and systemically that are triggered by chronic overproduction of type I interferon (IFN), including IFN\u2010alpha. Emerging disease\u2010directed therapies aim to dampen autoinflammation and block cellular responses to IFN production, creating an urgent and unmet need to understand better which cells, compartments, and mechanisms underlying disease pathogenesis. In this review, we highlight existing pre\u2010clinical models of AGS and our current understanding of how causative genetic mutations promote disease in AGS, to promote new model development and a continued focus on improving and directing future therapies.<\/jats:p>","DOI":"10.1111\/imr.13413","type":"journal-article","created":{"date-parts":[[2024,10,30]],"date-time":"2024-10-30T04:13:36Z","timestamp":1730261616000},"page":"83-99","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["The prototypical interferonopathy: Aicardi\u2010Gouti\u00e8res syndrome from bedside to bench"],"prefix":"10.1111","volume":"327","author":[{"given":"Markus J.","family":"Hofer","sequence":"first","affiliation":[{"name":"Charles Perkins Centre and School of Life and Environmental Sciences The University of Sydney  New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholson","family":"Modesti","sequence":"additional","affiliation":[{"name":"Division of Neurology, Department of Pediatrics Children's Hospital of Philadelphia  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole G.","family":"Coufal","sequence":"additional","affiliation":[{"name":"Department of Pediatrics University of California  San Diego California USA"},{"name":"Rady Children's Hospital  San Diego California USA"},{"name":"Sanford Consortium for Regenerative Medicine  San Diego California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingde","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Surgery University of Pittsburgh School of Medicine  Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sunetra","family":"Sase","sequence":"additional","affiliation":[{"name":"Division of Neurology, Department of Pediatrics Children's Hospital of Philadelphia  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan J.","family":"Miner","sequence":"additional","affiliation":[{"name":"Department of Medicine and Microbiology, RVCL Research Center, and Colton Center for Autoimmunity University of Pennsylvania Perelman School of Medicine  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adeline","family":"Vanderver","sequence":"additional","affiliation":[{"name":"Division of Neurology, Department of Pediatrics Children's Hospital of Philadelphia  Philadelphia Pennsylvania USA"},{"name":"Department of Neurology, Perelman School of Medicine University of Pennsylvania  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1642-2887","authenticated-orcid":false,"given":"Mariko L.","family":"Bennett","sequence":"additional","affiliation":[{"name":"Division of Neurology, Department of Pediatrics Children's Hospital of Philadelphia  Philadelphia Pennsylvania USA"},{"name":"Department of Neurology, Perelman School of Medicine University of Pennsylvania  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,10,29]]},"reference":[{"key":"e_1_2_10_2_1","volume-title":"Aicardi\u2010Gouti\u00e8res Syndrome. In GeneReviews\u00ae","author":"Crow YJ","year":"2005"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri3850"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10875-022-01209-5"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/jimd.12721"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/rmdopen-2022-002864"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2022.02.031"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3182872694"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1086\/521373"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(13)70258-8"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10875-020-00952-x"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2024.05.017"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410150109"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-8628(19980217)75:5<508::AID-AJMG10>3.0.CO;2-O"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005072-195404000-00002"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s004010051071"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1053\/ejpn.2002.0570"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1177\/1093526619837797"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/acn3.213"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.37577"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.36887"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2016-05-715987"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/pde.15437"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMc2001362"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmg.2016.12.004"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0040-1722673"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymgme.2022.06.003"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10875-024-01672-2"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.24.15.6719-6727.2004"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-022-04878-9"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.880413"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1600722"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1423804112"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2015.07.022"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2019.03.001"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-022-04642-z"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20120876"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2012.04.011"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.15252\/embj.201593339"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20151464"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2018.10.019"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1719771115"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1038\/emboj.2013.163"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2013.07.037"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M310162200"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M311347200"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2021.109500"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1017241108"},{"key":"e_1_2_10_49_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1009516"},{"key":"e_1_2_10_50_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aac7049"},{"key":"e_1_2_10_51_1","doi-asserted-by":"publisher","DOI":"10.1261\/rna.072728.119"},{"key":"e_1_2_10_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2021.07.001"},{"key":"e_1_2_10_53_1","doi-asserted-by":"publisher","DOI":"10.15252\/embr.202255835"},{"key":"e_1_2_10_54_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-021-02217-9"},{"key":"e_1_2_10_55_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.2100526"},{"key":"e_1_2_10_56_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-022-02646-0"},{"key":"e_1_2_10_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2021.08.011"},{"key":"e_1_2_10_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2021.08.022"},{"key":"e_1_2_10_59_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.161.9.5016"},{"key":"e_1_2_10_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2022.102794"},{"key":"e_1_2_10_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2013.12.014"},{"key":"e_1_2_10_62_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.3766"},{"key":"e_1_2_10_63_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature04734"},{"key":"e_1_2_10_64_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0603082103"},{"key":"e_1_2_10_65_1","doi-asserted-by":"publisher","DOI":"10.1038\/cddis.2013.125"},{"key":"e_1_2_10_66_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0903324106"},{"key":"e_1_2_10_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gene.2012.10.068"},{"key":"e_1_2_10_68_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2015.08.002"},{"key":"e_1_2_10_69_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdermsci.2011.06.013"},{"key":"e_1_2_10_70_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2015.11.001"},{"key":"e_1_2_10_71_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.122.320839"},{"key":"e_1_2_10_72_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)94303-6"},{"key":"e_1_2_10_73_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M111.276287"},{"key":"e_1_2_10_74_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2023.112733"},{"key":"e_1_2_10_75_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12883-021-02250-4"},{"key":"e_1_2_10_76_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1400737"},{"key":"e_1_2_10_77_1","doi-asserted-by":"publisher","DOI":"10.1093\/intimm\/dxaa073"},{"key":"e_1_2_10_78_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1900354"},{"key":"e_1_2_10_79_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2021.09.040"},{"key":"e_1_2_10_80_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.00587"},{"key":"e_1_2_10_81_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1301603"},{"key":"e_1_2_10_82_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2011.11.018"},{"key":"e_1_2_10_83_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1900220"},{"key":"e_1_2_10_84_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.202149324"},{"key":"e_1_2_10_85_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.1036799"},{"key":"e_1_2_10_86_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(99)01328-1"},{"key":"e_1_2_10_87_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-022-02441-x"},{"key":"e_1_2_10_88_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng1845"},{"key":"e_1_2_10_89_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.274.28.19655"},{"key":"e_1_2_10_90_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng2091"},{"key":"e_1_2_10_91_1","doi-asserted-by":"publisher","DOI":"10.1086\/513443"},{"key":"e_1_2_10_92_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10875-018-0584-x"},{"key":"e_1_2_10_93_1","doi-asserted-by":"publisher","DOI":"10.1038\/gene.2010.73"},{"key":"e_1_2_10_94_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng2082"},{"key":"e_1_2_10_95_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cccb.2022.100046"},{"key":"e_1_2_10_96_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.msard.2021.103015"},{"key":"e_1_2_10_97_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2008.06.032"},{"key":"e_1_2_10_98_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1500969"},{"key":"e_1_2_10_99_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.coi.2014.10.009"},{"key":"e_1_2_10_100_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gky002"},{"key":"e_1_2_10_101_1","doi-asserted-by":"publisher","DOI":"10.1002\/gene.10008"},{"key":"e_1_2_10_102_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddx283"},{"key":"e_1_2_10_103_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature23470"},{"key":"e_1_2_10_104_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature23449"},{"key":"e_1_2_10_105_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M112.431148"},{"key":"e_1_2_10_106_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1009523"},{"key":"e_1_2_10_107_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20220829"},{"key":"e_1_2_10_108_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2016.07.002"},{"key":"e_1_2_10_109_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-018-0050-1"},{"key":"e_1_2_10_110_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-017-02783-8"},{"key":"e_1_2_10_111_1","doi-asserted-by":"publisher","DOI":"10.1134\/S0006297911080050"},{"key":"e_1_2_10_112_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2021757118"},{"key":"e_1_2_10_113_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.2414"},{"key":"e_1_2_10_114_1","doi-asserted-by":"publisher","DOI":"10.1136\/jmedgenet-2013-102038"},{"key":"e_1_2_10_115_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2015.12.034"},{"key":"e_1_2_10_116_1","doi-asserted-by":"publisher","DOI":"10.3389\/fped.2022.852903"},{"key":"e_1_2_10_117_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejpn.2017.11.003"},{"key":"e_1_2_10_118_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.16610"},{"key":"e_1_2_10_119_1","doi-asserted-by":"publisher","DOI":"10.1111\/dmcn.15025"},{"key":"e_1_2_10_120_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12519-022-00545-1"},{"key":"e_1_2_10_121_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-022-04974-w"},{"key":"e_1_2_10_122_1","doi-asserted-by":"publisher","DOI":"10.1261\/rna.1518009"},{"key":"e_1_2_10_123_1","doi-asserted-by":"publisher","DOI":"10.1261\/rna.2566811"},{"key":"e_1_2_10_124_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/aws321"},{"key":"e_1_2_10_125_1","doi-asserted-by":"publisher","DOI":"10.1002\/glia.20639"},{"key":"e_1_2_10_126_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3711-09.2010"},{"key":"e_1_2_10_127_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI200318637"},{"key":"e_1_2_10_128_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.252454799"},{"key":"e_1_2_10_129_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI169562"},{"key":"e_1_2_10_130_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1403157"},{"key":"e_1_2_10_131_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.623650"},{"key":"e_1_2_10_132_1","doi-asserted-by":"publisher","DOI":"10.1089\/hum.2017.163"},{"key":"e_1_2_10_133_1","doi-asserted-by":"publisher","DOI":"10.1002\/dneu.22918"},{"key":"e_1_2_10_134_1","doi-asserted-by":"publisher","DOI":"10.1093\/braincomms\/fcac339"},{"key":"e_1_2_10_135_1","doi-asserted-by":"publisher","DOI":"10.3389\/fvets.2022.831838"},{"key":"e_1_2_10_136_1","doi-asserted-by":"publisher","DOI":"10.3389\/fvets.2022.961413"},{"key":"e_1_2_10_137_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2020.107689"},{"key":"e_1_2_10_138_1","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.2623"},{"key":"e_1_2_10_139_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2017.07.009"},{"key":"e_1_2_10_140_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20211121"},{"key":"e_1_2_10_141_1","doi-asserted-by":"publisher","DOI":"10.1002\/cpt.1837"},{"key":"e_1_2_10_142_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.scr.2022.102895"},{"key":"e_1_2_10_143_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.scr.2019.101580"},{"key":"e_1_2_10_144_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.scr.2019.101620"},{"key":"e_1_2_10_145_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.scr.2019.101623"},{"key":"e_1_2_10_146_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.scr.2022.102912"},{"key":"e_1_2_10_147_1","doi-asserted-by":"publisher","DOI":"10.3390\/genes11050511"},{"key":"e_1_2_10_148_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.scr.2019.101697"},{"key":"e_1_2_10_149_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aal3222"},{"key":"e_1_2_10_150_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2023.07.016"},{"key":"e_1_2_10_151_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2015.11.013"},{"key":"e_1_2_10_152_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aay0793"},{"key":"e_1_2_10_153_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.abn6579"},{"key":"e_1_2_10_154_1","doi-asserted-by":"publisher","DOI":"10.3389\/fbioe.2023.1108340"},{"key":"e_1_2_10_155_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2022.10.008"},{"key":"e_1_2_10_156_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2023.01.004"},{"key":"e_1_2_10_157_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.84.14_supplement.S52.00"},{"key":"e_1_2_10_158_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.2475"},{"key":"e_1_2_10_159_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.201902508R"},{"key":"e_1_2_10_160_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms11752"},{"key":"e_1_2_10_161_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI78001"},{"key":"e_1_2_10_162_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1002425"},{"key":"e_1_2_10_163_1","doi-asserted-by":"publisher","DOI":"10.1101\/2023.02.23.529707"}],"container-title":["Immunological Reviews"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/imr.13413","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,20]],"date-time":"2024-11-20T05:53:06Z","timestamp":1732081986000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/imr.13413"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10]]},"references-count":162,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2024,10]]}},"alternative-id":["10.1111\/imr.13413"],"URL":"https:\/\/doi.org\/10.1111\/imr.13413","archive":["Portico"],"relation":{},"ISSN":["0105-2896","1600-065X"],"issn-type":[{"value":"0105-2896","type":"print"},{"value":"1600-065X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,10]]},"assertion":[{"value":"2024-10-29","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}