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The \u03b2 common (\u03b2c) cytokine receptor family, consisting of the granulocyte\u2010macrophage colony\u2010stimulating factor (GM\u2010CSF), interleukin (IL)\u20103, and IL\u20105 cytokine receptors, is an architype of the heterodimeric cytokine receptor systems. We now know that signaling by cytokine receptors is not always an \u201call or none\u201d phenomenon. Subtle alterations of the cytokine:receptor complex can result in differential or selective signaling and underpin a variety of diseases including chronic inflammatory conditions and cancers. Structural biology techniques, such as X\u2010ray crystallography and cryo\u2010electron microscopy alongside cell biology studies, are providing detailed insights into cytokine receptor signaling. 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