{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T06:33:40Z","timestamp":1790922820760,"version":"4.1.0"},"reference-count":232,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,12,27]],"date-time":"2024-12-27T00:00:00Z","timestamp":1735257600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000865","name":"Bill and Melinda Gates Foundation","doi-asserted-by":"publisher","award":["INV\u2010004923"],"award-info":[{"award-number":["INV\u2010004923"]}],"id":[{"id":"10.13039\/100000865","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Immunological Reviews"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>The SARS\u2010CoV\u20102 spike (S) protein has undergone significant evolution, enhancing both receptor binding and immune evasion. In this review, we summarize ongoing efforts to develop antibodies targeting various epitopes of the S protein, focusing on their neutralization potency, breadth, and escape mechanisms. Antibodies targeting the receptor\u2010binding site (RBS) typically exhibit high neutralizing potency but are frequently evaded by mutations in SARS\u2010CoV\u20102 variants. In contrast, antibodies targeting conserved regions, such as the S2 stem helix and fusion peptide, exhibit broader reactivity but generally lower neutralization potency. However, several broadly neutralizing antibodies have demonstrated exceptional efficacy against emerging variants, including the latest omicron subvariants, underscoring the potential of targeting vulnerable sites such as RBS\u2010A and RBS\u2010D\/CR3022. We also highlight public classes of antibodies targeting different sites on the S protein. The vulnerable sites targeted by public antibodies present opportunities for germline\u2010targeting vaccine strategies. Overall, developing escape\u2010resistant, potent antibodies and broadly effective vaccines remains crucial for combating future variants. This review emphasizes the importance of identifying key epitopes and utilizing antibody affinity maturation to inform future therapeutic and vaccine design.<\/jats:p>","DOI":"10.1111\/imr.13431","type":"journal-article","created":{"date-parts":[[2024,12,28]],"date-time":"2024-12-28T04:58:12Z","timestamp":1735361892000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Structural Immunology of <scp>SARS<\/scp>\u2010<scp>CoV<\/scp>\u20102"],"prefix":"10.1111","volume":"329","author":[{"given":"Meng","family":"Yuan","sequence":"first","affiliation":[{"name":"Department of Integrative Structural and Computational Biology The Scripps Research Institute  La Jolla California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6469-2419","authenticated-orcid":false,"given":"Ian A.","family":"Wilson","sequence":"additional","affiliation":[{"name":"Department of Integrative Structural and Computational Biology The Scripps Research Institute  La Jolla California USA"},{"name":"The Skaggs Institute for Chemical Biology The Scripps Research Institute  La Jolla California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,12,27]]},"reference":[{"key":"e_1_2_14_2_1","unstructured":"WHO \u201cWHO COVID\u201019 Dashboard \u201dhttps:\/\/data.who.int\/dashboards\/covid19\/cases."},{"key":"e_1_2_14_3_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.abi9745"},{"key":"e_1_2_14_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/msb.2011.75"},{"key":"e_1_2_14_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btl529"},{"key":"e_1_2_14_6_1","article-title":"Neutralizing Antibodies Targeting SARS\u2010CoV\u20102 Spike Protein","volume":"50","author":"Shi X.","year":"2020","journal-title":"Stem Cell Research"},{"key":"e_1_2_14_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41577-022-00784-3"},{"key":"e_1_2_14_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2023.02.005"},{"key":"e_1_2_14_9_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.abq3773"},{"key":"e_1_2_14_10_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.abq2679"},{"key":"e_1_2_14_11_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.abj3321"},{"key":"e_1_2_14_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2022.03.019"},{"key":"e_1_2_14_13_1","unstructured":"WHO \u201cSummary of Probable SARS Cases With Onset of Illness from 1 November 2002 to 31 July 2003 \u201dhttps:\/\/www.who.int\/publications\/m\/item\/summary\u2010of\u2010probable\u2010sars\u2010cases\u2010with\u2010onset\u2010of\u2010illness\u2010from\u20101\u2010november\u20102002\u2010to\u201031\u2010july\u20102003."},{"key":"e_1_2_14_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/ve\/veab064"},{"key":"e_1_2_14_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/bty407"},{"key":"e_1_2_14_16_1","doi-asserted-by":"publisher","DOI":"10.2807\/1560-7917.ES.2017.22.13.30494"},{"key":"e_1_2_14_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41592-023-01769-3"},{"key":"e_1_2_14_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2007.05.022"},{"key":"e_1_2_14_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2020.06.043"},{"key":"e_1_2_14_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2020.09.032"},{"key":"e_1_2_14_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-020-2895-3"},{"key":"e_1_2_14_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-28768-w"},{"key":"e_1_2_14_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2021.12.046"},{"key":"e_1_2_14_24_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkq399"},{"key":"e_1_2_14_25_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.abh1139"},{"key":"e_1_2_14_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-021-04387-1"},{"key":"e_1_2_14_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-021-04385-3"},{"key":"e_1_2_14_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-021-04386-2"},{"key":"e_1_2_14_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-021-04389-z"},{"key":"e_1_2_14_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-021-04388-0"},{"key":"e_1_2_14_31_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-022-04399-5"},{"key":"e_1_2_14_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-022-04594-4"},{"key":"e_1_2_14_33_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2205784119"},{"key":"e_1_2_14_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2024.06.028"},{"key":"e_1_2_14_35_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.69091"},{"key":"e_1_2_14_36_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-022-04980-y"},{"issue":"7948","key":"e_1_2_14_37_1","first-page":"521","article-title":"Imprinted SARS\u2010CoV\u20102 Humoral Immunity Induces Convergent Omicron RBD Evolution","volume":"614","author":"Cao Y.","year":"2023","journal-title":"Nature"},{"key":"e_1_2_14_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(23)00010-5"},{"key":"e_1_2_14_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(23)00051-8"},{"key":"e_1_2_14_40_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1010951"},{"key":"e_1_2_14_41_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.abo7896"},{"key":"e_1_2_14_42_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41421-024-00752-2"},{"key":"e_1_2_14_43_1","doi-asserted-by":"publisher","DOI":"10.1093\/ve\/veae067"},{"key":"e_1_2_14_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2021.109822"},{"key":"e_1_2_14_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2020.09.037"},{"key":"e_1_2_14_46_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1010592"},{"key":"e_1_2_14_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2021.03.028"},{"key":"e_1_2_14_48_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40259-022-00529-7"},{"key":"e_1_2_14_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2020.10.012"},{"key":"e_1_2_14_50_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.abd2321"},{"key":"e_1_2_14_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2020.06.025"},{"key":"e_1_2_14_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2021.12.010"},{"key":"e_1_2_14_53_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-020-2852-1"},{"key":"e_1_2_14_54_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-020-2381-y"},{"key":"e_1_2_14_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.xcrm.2021.100255"},{"key":"e_1_2_14_56_1","doi-asserted-by":"crossref","unstructured":"F.Jian A. Z.Wec L.Feng et\u00a0al. \u201cA Generalized Framework to Identify SARS\u2010CoV\u20102 Broadly Neutralizing Antibodies \u201dbioRxiv 2024.04.16.589454.","DOI":"10.1101\/2024.04.16.589454"},{"key":"e_1_2_14_57_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1011856"},{"key":"e_1_2_14_58_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41564-021-00972-2"},{"key":"e_1_2_14_59_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-024-45171-9"},{"key":"e_1_2_14_60_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.abc5902"},{"key":"e_1_2_14_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2020.108274"},{"key":"e_1_2_14_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2022.111650"},{"key":"e_1_2_14_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2022.110812"},{"key":"e_1_2_14_64_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-39267-x"},{"key":"e_1_2_14_65_1","doi-asserted-by":"publisher","DOI":"10.1093\/abt\/tbad006"},{"key":"e_1_2_14_66_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.adc9127"},{"key":"e_1_2_14_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2020.10.023"},{"key":"e_1_2_14_68_1","doi-asserted-by":"publisher","DOI":"10.1038\/s42003-022-03700-6"},{"key":"e_1_2_14_69_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.abn6859"},{"key":"e_1_2_14_70_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.abc6952"},{"key":"e_1_2_14_71_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2024.114307"},{"key":"e_1_2_14_72_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2317222121"},{"key":"e_1_2_14_73_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-32232-0"},{"key":"e_1_2_14_74_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2022.10.010"},{"key":"e_1_2_14_75_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-24123-7"},{"key":"e_1_2_14_76_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2021.03.027"},{"key":"e_1_2_14_77_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2024.105354"},{"key":"e_1_2_14_78_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-020-2380-z"},{"key":"e_1_2_14_79_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2020.09.035"},{"key":"e_1_2_14_80_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.abg6916"},{"key":"e_1_2_14_81_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2021.06.003"},{"key":"e_1_2_14_82_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.abq3511"},{"key":"e_1_2_14_83_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2021.03.055"},{"key":"e_1_2_14_84_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.abm5835"},{"key":"e_1_2_14_85_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.xcrm.2024.101577"},{"key":"e_1_2_14_86_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2022.07.002"},{"key":"e_1_2_14_87_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2021.04.015"},{"key":"e_1_2_14_88_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.isci.2024.110354"},{"key":"e_1_2_14_89_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.adp9927"},{"key":"e_1_2_14_90_1","unstructured":"X.Chen L.Li R.Du et\u00a0al. \u201cLongitudinal Profiling of B Cells Primed by mRNA Vaccine and Recalled by Omicron Variants Uncovers Antibodies Broadly Neutralizing Sarbecoviruses \u201dbioRxiv 2024:2024.10.13.618110."},{"key":"e_1_2_14_91_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.abm8143"},{"key":"e_1_2_14_92_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-024-51973-8"},{"key":"e_1_2_14_93_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.ado2817"},{"key":"e_1_2_14_94_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2022.05.014"},{"key":"e_1_2_14_95_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkt382"},{"key":"e_1_2_14_96_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2666-5247(21)00068-9"},{"key":"e_1_2_14_97_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-021-03398-2"},{"key":"e_1_2_14_98_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2021.108950"},{"key":"e_1_2_14_99_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-020-2456-9"},{"key":"e_1_2_14_100_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.abe3354"},{"key":"e_1_2_14_101_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.abh1766"},{"key":"e_1_2_14_102_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-020-2548-6"},{"key":"e_1_2_14_103_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.abn8897"},{"key":"e_1_2_14_104_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2021.02.032"},{"key":"e_1_2_14_105_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2021.11.013"},{"key":"e_1_2_14_106_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-022-04466-x"},{"key":"e_1_2_14_107_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-023-01615-0"},{"key":"e_1_2_14_108_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41564-022-01198-6"},{"key":"e_1_2_14_109_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2023.11.004"},{"key":"e_1_2_14_110_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2020.09.049"},{"key":"e_1_2_14_111_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2020.05.025"},{"key":"e_1_2_14_112_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41422-020-00444-y"},{"key":"e_1_2_14_113_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-022-00910-6"},{"key":"e_1_2_14_114_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.abd0827"},{"key":"e_1_2_14_115_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(22)00365-6"},{"key":"e_1_2_14_116_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.str.2021.05.014"},{"key":"e_1_2_14_117_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.abb7269"},{"key":"e_1_2_14_118_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2020.06.010"},{"key":"e_1_2_14_119_1","doi-asserted-by":"crossref","unstructured":"M. G.Joyce R. S.Sankhala W. H.Chen et\u00a0al. \u201cA Cryptic Site of Vulnerability on the Receptor Binding Domain of the SARS\u2010CoV\u20102 Spike Glycoprotein \u201dbioRxiv 2020.","DOI":"10.1101\/2020.03.15.992883"},{"key":"e_1_2_14_120_1","doi-asserted-by":"publisher","DOI":"10.1080\/22221751.2020.1729069"},{"key":"e_1_2_14_121_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1009089"},{"key":"e_1_2_14_122_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.0030237"},{"key":"e_1_2_14_123_1","doi-asserted-by":"publisher","DOI":"10.1126\/scisignal.abk3516"},{"key":"e_1_2_14_124_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.isci.2023.108009"},{"key":"e_1_2_14_125_1","doi-asserted-by":"crossref","unstructured":"G.Song M.Yuan H.Liu et\u00a0al. \u201cBroadly Neutralizing Antibodies Targeting a Conserved Silent Face of Spike RBD Resist Extreme SARS\u2010CoV\u20102 Antigenic Drift \u201dbioRxiv 2023.","DOI":"10.1101\/2023.04.26.538488"},{"key":"e_1_2_14_126_1","doi-asserted-by":"publisher","DOI":"10.3390\/vaccines12050467"},{"key":"e_1_2_14_127_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2018.09.010"},{"key":"e_1_2_14_128_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-024-51770-3"},{"key":"e_1_2_14_129_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2022.06.005"},{"key":"e_1_2_14_130_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-023-01449-6"},{"key":"e_1_2_14_131_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2021.04.033"},{"key":"e_1_2_14_132_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-021-01068-z"},{"key":"e_1_2_14_133_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-35949-8"},{"key":"e_1_2_14_134_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.str.2023.04.010"},{"key":"e_1_2_14_135_1","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.00480-22"},{"key":"e_1_2_14_136_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-33030-4"},{"key":"e_1_2_14_137_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.abf4830"},{"key":"e_1_2_14_138_1","unstructured":"\u201cInvivyd Provides Detailed Virology Data and Analysis of SARS\u2010CoV\u20102 Structural Biology Predicting Anticipated Neutralization Activity for PEMGARDA\u2122 (Pemivibart) \u201d2024 https:\/\/investors.invivyd.com\/news\u2010releases\/news\u2010release\u2010details\/invivyd\u2010provides\u2010detailed\u2010virology\u2010data\u2010and\u2010analysis\u2010sars\u2010cov\u20102."},{"key":"e_1_2_14_139_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-022-04778-y"},{"key":"e_1_2_14_140_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2022.111845"},{"key":"e_1_2_14_141_1","doi-asserted-by":"publisher","DOI":"10.20411\/pai.v10i1.752"},{"key":"e_1_2_14_142_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.xcrm.2024.101668"},{"key":"e_1_2_14_143_1","doi-asserted-by":"publisher","DOI":"10.1080\/22221751.2024.2402880"},{"key":"e_1_2_14_144_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-020-2349-y"},{"key":"e_1_2_14_145_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41557-021-00758-3"},{"key":"e_1_2_14_146_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2021.04.005"},{"key":"e_1_2_14_147_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.isci.2022.104914"},{"key":"e_1_2_14_148_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.abc7520"},{"key":"e_1_2_14_149_1","doi-asserted-by":"crossref","unstructured":"Y.Cao A.Yisimayi F.Jian et\u00a0al. \u201cOmicron BA.2 Specifically Evades Broad Sarbecovirus Neutralizing Antibodies \u201dbioRxiv 2022.","DOI":"10.1101\/2022.02.07.479349"},{"key":"e_1_2_14_150_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-021-03807-6"},{"key":"e_1_2_14_151_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2021.06.020"},{"key":"e_1_2_14_152_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2022.110348"},{"key":"e_1_2_14_153_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.678570"},{"key":"e_1_2_14_154_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-25997-3"},{"key":"e_1_2_14_155_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2022.110862"},{"key":"e_1_2_14_156_1","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.01596-22"},{"key":"e_1_2_14_157_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.str.2023.11.015"},{"key":"e_1_2_14_158_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2314193120"},{"key":"e_1_2_14_159_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-022-01222-1"},{"key":"e_1_2_14_160_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.202149234"},{"key":"e_1_2_14_161_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-020-2571-7"},{"key":"e_1_2_14_162_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2021.03.005"},{"key":"e_1_2_14_163_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2021.06.021"},{"key":"e_1_2_14_164_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2021.03.029"},{"key":"e_1_2_14_165_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.abh2315"},{"key":"e_1_2_14_166_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.abg5268"},{"key":"e_1_2_14_167_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41422-020-00446-w"},{"key":"e_1_2_14_168_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.abl8506"},{"key":"e_1_2_14_169_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.abi7994"},{"key":"e_1_2_14_170_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.abn8652"},{"key":"e_1_2_14_171_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2022.04.003"},{"key":"e_1_2_14_172_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2021.109928"},{"key":"e_1_2_14_173_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2021.03.023"},{"key":"e_1_2_14_174_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.abg7607"},{"key":"e_1_2_14_175_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2022.05.001"},{"key":"e_1_2_14_176_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2022.12.018"},{"key":"e_1_2_14_177_1","doi-asserted-by":"publisher","DOI":"10.1080\/22221751.2021.2024455"},{"key":"e_1_2_14_178_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-022-04581-9"},{"key":"e_1_2_14_179_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-024-53033-7"},{"key":"e_1_2_14_180_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1011868"},{"key":"e_1_2_14_181_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-024-46982-6"},{"key":"e_1_2_14_182_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(23)00573-X"},{"key":"e_1_2_14_183_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41580-021-00418-x"},{"key":"e_1_2_14_184_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-2836(91)90193-A"},{"key":"e_1_2_14_185_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41564-022-01155-3"},{"key":"e_1_2_14_186_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.ade0958"},{"key":"e_1_2_14_187_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1012383"},{"key":"e_1_2_14_188_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.abi6226"},{"key":"e_1_2_14_189_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-024-48104-8"},{"key":"e_1_2_14_190_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41594-022-00735-5"},{"key":"e_1_2_14_191_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-024-50976-9"},{"key":"e_1_2_14_192_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.83710"},{"key":"e_1_2_14_193_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.str.2024.08.022"},{"key":"e_1_2_14_194_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-23074-3"},{"key":"e_1_2_14_195_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.abi9215"},{"key":"e_1_2_14_196_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2021.109353"},{"key":"e_1_2_14_197_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2021.110210"},{"key":"e_1_2_14_198_1","doi-asserted-by":"publisher","DOI":"10.1038\/s42003-022-03262-7"},{"key":"e_1_2_14_199_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41594-021-00596-4"},{"key":"e_1_2_14_200_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2021.109929"},{"key":"e_1_2_14_201_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.str.2022.06.004"},{"key":"e_1_2_14_202_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.adn5658"},{"key":"e_1_2_14_203_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2017.06.015"},{"key":"e_1_2_14_204_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1715471115"},{"key":"e_1_2_14_205_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1005238"},{"key":"e_1_2_14_206_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.xcrm.2023.100991"},{"key":"e_1_2_14_207_1","doi-asserted-by":"publisher","DOI":"10.1080\/21645515.2024.2388344"},{"key":"e_1_2_14_208_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2023.113444"},{"key":"e_1_2_14_209_1","doi-asserted-by":"publisher","DOI":"10.1080\/14712598.2024.2326647"},{"key":"e_1_2_14_210_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.abc7424"},{"key":"e_1_2_14_211_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2024.09.026"},{"key":"e_1_2_14_212_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-38345-4"},{"key":"e_1_2_14_213_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586\u2010024\u201008315\u2010x"},{"key":"e_1_2_14_214_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-023-06753-7"},{"key":"e_1_2_14_215_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-023-06025-4"},{"key":"e_1_2_14_216_1","doi-asserted-by":"publisher","DOI":"10.1080\/22221751.2024.2412990"},{"key":"e_1_2_14_217_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41579-022-00708-x"},{"key":"e_1_2_14_218_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2666-5247(23)00411-1"},{"key":"e_1_2_14_219_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2023.113194"},{"key":"e_1_2_14_220_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.coi.2024.102429"},{"key":"e_1_2_14_221_1","doi-asserted-by":"publisher","DOI":"10.1101\/pdb.top115"},{"key":"e_1_2_14_222_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btz184"},{"key":"e_1_2_14_223_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-023-06750-w"},{"key":"e_1_2_14_224_1","doi-asserted-by":"publisher","DOI":"10.3390\/v14030640"},{"key":"e_1_2_14_225_1","doi-asserted-by":"publisher","DOI":"10.1038\/s44318-024-00062-z"},{"key":"e_1_2_14_226_1","doi-asserted-by":"crossref","unstructured":"Z.Feng J.Huang S.Baboo et\u00a0al. \u201cStructural and Functional Insights Into the Evolution of SARS\u2010CoV\u20102 KP.3.1.1 Spike Protein \u201dbioRxiv 2024:2024.12.10.627775.","DOI":"10.1101\/2024.12.10.627775"},{"key":"e_1_2_14_227_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2022.110729"},{"key":"e_1_2_14_228_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.isci.2023.105981"},{"key":"e_1_2_14_229_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2022.111009"},{"key":"e_1_2_14_230_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2022.03.028"},{"key":"e_1_2_14_231_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2022.110428"},{"key":"e_1_2_14_232_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2208343"},{"key":"e_1_2_14_233_1","unstructured":"\u201cFDA Approves And Authorizes Updated mRNA COVID\u201019 Vaccines to Better Protect Against Currently Circulating Variants \u201d2024 https:\/\/www.fda.gov\/news\u2010events\/press\u2010announcements\/fda\u2010approves\u2010and\u2010authorizes\u2010updated\u2010mrna\u2010covid\u201019\u2010vaccines\u2010better\u2010protect\u2010against\u2010currently."}],"container-title":["Immunological Reviews"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/imr.13431","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,13]],"date-time":"2025-02-13T13:03:23Z","timestamp":1739451803000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/imr.13431"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12,27]]},"references-count":232,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,1]]}},"alternative-id":["10.1111\/imr.13431"],"URL":"https:\/\/doi.org\/10.1111\/imr.13431","archive":["Portico"],"relation":{},"ISSN":["0105-2896","1600-065X"],"issn-type":[{"value":"0105-2896","type":"print"},{"value":"1600-065X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,12,27]]},"assertion":[{"value":"2024-11-07","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-12-10","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-12-27","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e13431"}}