{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T01:26:22Z","timestamp":1780622782059,"version":"3.54.1"},"reference-count":145,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,12,26]],"date-time":"2024-12-26T00:00:00Z","timestamp":1735171200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["DK048549"],"award-info":[{"award-number":["DK048549"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["DK088327"],"award-info":[{"award-number":["DK088327"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["HL141366"],"award-info":[{"award-number":["HL141366"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000968","name":"American Heart Association","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["AI146871"],"award-info":[{"award-number":["AI146871"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["AI168393"],"award-info":[{"award-number":["AI168393"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Immunological Reviews"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Innate immune cells perform vital tasks in detecting, seeking, and eliminating invading pathogens, thus ensuring host survival. However, loss of function of these cells or their overactive response to tissue injury often causes serious ailments. It is, therefore, crucial to understand at a basic level how these cells function in health and disease. A major step toward this goal came from studies I conducted in the late 1970s investigating the cause of life\u2010threatening bacterial infections in a pediatric patient. This work led us to trace this disease to the inability of the patient's neutrophils to seek and clear infections due to an inherited deficiency in leukocyte adhesion caused by the loss of a plasma membrane glycoprotein complex now known as CD11\/CD18 or \u03b22 integrins. I followed this work by determining the 3\u2010dimensional structures of integrins. These studies provided the foundation for understanding the unique properties of integrins in mediating bidirectional cell adhesion signaling and enabled a structure\u2010guided design of compounds to dial down overactive integrins in common disorders, including thromboinflammatory and autoimmune diseases.<\/jats:p>","DOI":"10.1111\/imr.13433","type":"journal-article","created":{"date-parts":[[2024,12,26]],"date-time":"2024-12-26T14:11:31Z","timestamp":1735222291000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["The Integrin Receptors: From Discovery to Structure to Medicines"],"prefix":"10.1111","volume":"329","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8270-0371","authenticated-orcid":false,"given":"M. Amin","family":"Arnaout","sequence":"first","affiliation":[{"name":"Massachusetts General Hospital Harvard Medical School  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,12,26]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"crossref","unstructured":"M. A.Arnaout J.Pitt H. J.Cohen J.Melamed F. S.Rosen andH. R.Colten \u201cDefects in Compelment C3 Receptor\u2010Coupled Functions with Normal C3b Receptor and Affinity in Human Neutrophils that Lack a Surface Membrane Glycoprotein (GP150).\u201dAbstracts of the IXth International Complement Workshop Key Biscayne Florida November 21\u201025 1981. Mol Immunol 19 no. 11 (1982) 1357\u20131413.","DOI":"10.1016\/0161-5890(82)90012-8"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198203253061201"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198005223022102"},{"key":"e_1_2_13_5_1","first-page":"489","article-title":"Deficiency of a Monocyte\u2010Granulocyte Surface Glycoprotein Mo1 in Man","volume":"31","author":"Dana N.","year":"1983","journal-title":"Clinical Research"},{"key":"e_1_2_13_6_1","first-page":"301","article-title":"A Monoclonal Antibody Reactive With Peripheral Blood Monocytes","volume":"9","author":"Breard J.","year":"1980","journal-title":"European Journal of Immunology"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.126.4.1435"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI110955"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI111186"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbc.2021.100256"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.1830090410"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.154.5.1517"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.125.5.2208"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.127.2.590"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.80.18.5699"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.131.6.2913"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.158.6.1785"},{"key":"e_1_2_13_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(84)90933-4"},{"key":"e_1_2_13_19_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI111539"},{"key":"e_1_2_13_20_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI111538"},{"key":"e_1_2_13_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-065X.1990.tb00564.x"},{"key":"e_1_2_13_22_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.183.4.1415"},{"key":"e_1_2_13_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(82)80013-9"},{"key":"e_1_2_13_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/0167-5699(89)90271-5"},{"key":"e_1_2_13_25_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.189.9.1467"},{"key":"e_1_2_13_26_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.155.1.35"},{"key":"e_1_2_13_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.1830150714"},{"key":"e_1_2_13_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/1074-7613(95)90058-6"},{"key":"e_1_2_13_29_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI112868"},{"key":"e_1_2_13_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(87)90215-7"},{"key":"e_1_2_13_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(19)50738-4"},{"key":"e_1_2_13_32_1","first-page":"191","volume-title":"Concepts in Immunodeficiency Diseases Gupta","author":"Arnaout M. A.","year":"1993"},{"key":"e_1_2_13_33_1","first-page":"1622","article-title":"Deficiency of Leukocyte Surface Glycoproteins Mo1, LFA\u20101, and Leu\u2010M5 in a Dog With Recurrent Bacterial Infections: An Animal Model","volume":"69","author":"Giger U.","year":"1987","journal-title":"Blood"},{"key":"e_1_2_13_34_1","doi-asserted-by":"publisher","DOI":"10.2460\/ajvr.1990.51.11.1826"},{"key":"e_1_2_13_35_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.151.3.1571"},{"key":"e_1_2_13_36_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.173.1.297"},{"key":"e_1_2_13_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(00)80278-2"},{"key":"e_1_2_13_38_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.1041370214"},{"key":"e_1_2_13_39_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI115473"},{"key":"e_1_2_13_40_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.med.080708.082655"},{"key":"e_1_2_13_41_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2016-03-705160"},{"key":"e_1_2_13_42_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1974.tb06660.x"},{"key":"e_1_2_13_43_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1964.tb00714.x"},{"key":"e_1_2_13_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(66)90003-9"},{"key":"e_1_2_13_45_1","doi-asserted-by":"publisher","DOI":"10.1038\/257599a0"},{"key":"e_1_2_13_46_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI109983"},{"key":"e_1_2_13_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)34040-7"},{"key":"e_1_2_13_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(19)68787-9"},{"key":"e_1_2_13_49_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.80.9.2417"},{"key":"e_1_2_13_50_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI110946"},{"key":"e_1_2_13_51_1","doi-asserted-by":"publisher","DOI":"10.1002\/jss.400040107"},{"key":"e_1_2_13_52_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910200102"},{"key":"e_1_2_13_53_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.70.11.3170"},{"key":"e_1_2_13_54_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.70.12.3329"},{"key":"e_1_2_13_55_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910130502"},{"key":"e_1_2_13_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/0042-6822(74)90143-3"},{"key":"e_1_2_13_57_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.71.2.489"},{"key":"e_1_2_13_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(74)90115-9"},{"key":"e_1_2_13_59_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.95.2.654"},{"key":"e_1_2_13_60_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.1982.240180209"},{"key":"e_1_2_13_61_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.4012302"},{"key":"e_1_2_13_62_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.240280409"},{"key":"e_1_2_13_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4827(85)90164-8"},{"key":"e_1_2_13_64_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.82.17.5766"},{"key":"e_1_2_13_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(87)90233-9"},{"key":"e_1_2_13_66_1","doi-asserted-by":"publisher","DOI":"10.1038\/314540a0"},{"key":"e_1_2_13_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/0167-4838(86)90037-3"},{"key":"e_1_2_13_68_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.83.21.8351"},{"key":"e_1_2_13_69_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(86)90744-0"},{"key":"e_1_2_13_70_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.83.22.8614"},{"key":"e_1_2_13_71_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)69249-X"},{"key":"e_1_2_13_72_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)61290-6"},{"key":"e_1_2_13_73_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)47438-8"},{"key":"e_1_2_13_74_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(87)90246-7"},{"key":"e_1_2_13_75_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.1460-2075.1987.tb02746.x"},{"key":"e_1_2_13_76_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.106.6.2153"},{"key":"e_1_2_13_77_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.1460-2075.1988.tb02953.x"},{"key":"e_1_2_13_78_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.108.2.703"},{"key":"e_1_2_13_79_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.2420006"},{"key":"e_1_2_13_80_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.2821619"},{"key":"e_1_2_13_81_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(20)89452-6"},{"key":"e_1_2_13_82_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(19)47346-8"},{"key":"e_1_2_13_83_1","doi-asserted-by":"publisher","DOI":"10.1021\/bi00359a014"},{"key":"e_1_2_13_84_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.1460-2075.1986.tb04435.x"},{"key":"e_1_2_13_85_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(93)90575-B"},{"key":"e_1_2_13_86_1","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.e02-05-0259"},{"key":"e_1_2_13_87_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(95)90517-0"},{"key":"e_1_2_13_88_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0969-2126(01)00271-4"},{"key":"e_1_2_13_89_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.92.22.10277"},{"key":"e_1_2_13_90_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.C000563200"},{"key":"e_1_2_13_91_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1901402"},{"key":"e_1_2_13_92_1","doi-asserted-by":"publisher","DOI":"10.1038\/385833a0"},{"key":"e_1_2_13_93_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.88.8.3106"},{"key":"e_1_2_13_94_1","doi-asserted-by":"publisher","DOI":"10.1042\/bj3300861"},{"key":"e_1_2_13_95_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1064535"},{"key":"e_1_2_13_96_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.293.5536.1743b"},{"key":"e_1_2_13_97_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1066240"},{"key":"e_1_2_13_98_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrm821"},{"key":"e_1_2_13_99_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.1460-2075.1988.tb03303.x"},{"key":"e_1_2_13_100_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1069040"},{"key":"e_1_2_13_101_1","doi-asserted-by":"publisher","DOI":"10.1038\/nsmb.2797"},{"key":"e_1_2_13_102_1","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.E21-11-0536"},{"key":"e_1_2_13_103_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2008.03.014"},{"key":"e_1_2_13_104_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.271.39.23729"},{"key":"e_1_2_13_105_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0960-9822(02)00852-7"},{"key":"e_1_2_13_106_1","doi-asserted-by":"publisher","DOI":"10.1038\/emboj.2009.367"},{"key":"e_1_2_13_107_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.201308083"},{"key":"e_1_2_13_108_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(02)00935-2"},{"key":"e_1_2_13_109_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M111.275107"},{"key":"e_1_2_13_110_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2003-01-0334"},{"key":"e_1_2_13_111_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200908045"},{"key":"e_1_2_13_112_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsb.2005.03.005"},{"key":"e_1_2_13_113_1","doi-asserted-by":"publisher","DOI":"10.1111\/jth.12915"},{"key":"e_1_2_13_114_1","doi-asserted-by":"publisher","DOI":"10.1080\/09687680802269886"},{"key":"e_1_2_13_115_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-39763-0"},{"key":"e_1_2_13_116_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.str.2024.03.006"},{"key":"e_1_2_13_117_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2018.12.038"},{"key":"e_1_2_13_118_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2005-11-056689"},{"key":"e_1_2_13_119_1","doi-asserted-by":"publisher","DOI":"10.1529\/biophysj.108.131045"},{"key":"e_1_2_13_120_1","doi-asserted-by":"publisher","DOI":"10.1038\/emboj.2009.63"},{"key":"e_1_2_13_121_1","doi-asserted-by":"publisher","DOI":"10.5483\/BMBRep.2014.47.12.241"},{"key":"e_1_2_13_122_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.154.7.3461"},{"key":"e_1_2_13_123_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncb1201-1060"},{"key":"e_1_2_13_124_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrm3599"},{"key":"e_1_2_13_125_1","doi-asserted-by":"publisher","DOI":"10.1038\/nsmb.2999"},{"key":"e_1_2_13_126_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2008-06-077891"},{"key":"e_1_2_13_127_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrd.2015.10"},{"key":"e_1_2_13_128_1","doi-asserted-by":"publisher","DOI":"10.1021\/bi900475k"},{"key":"e_1_2_13_129_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-024-52869-3"},{"key":"e_1_2_13_130_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature02976"},{"key":"e_1_2_13_131_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.abe9716"},{"key":"e_1_2_13_132_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-24184-8"},{"key":"e_1_2_13_133_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.127.6.2081"},{"key":"e_1_2_13_134_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1102394"},{"key":"e_1_2_13_135_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.168.3.1219"},{"key":"e_1_2_13_136_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms13899"},{"key":"e_1_2_13_137_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-2836(03)00082-2"},{"key":"e_1_2_13_138_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-13928-2"},{"key":"e_1_2_13_139_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsptsci.9b00041"},{"key":"e_1_2_13_140_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3003576"},{"key":"e_1_2_13_141_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2007-03-080184"},{"key":"e_1_2_13_142_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2022.08.008"},{"key":"e_1_2_13_143_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1527-3466.2001.tb00181.x"},{"key":"e_1_2_13_144_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells9091923"},{"key":"e_1_2_13_145_1","doi-asserted-by":"publisher","DOI":"10.1038\/mp.2012.145"},{"key":"e_1_2_13_146_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0049-3848(02)00395-X"}],"updated-by":[{"DOI":"10.1111\/imr.70065","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T00:00:00Z","timestamp":1760486400000}}],"container-title":["Immunological Reviews"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/imr.13433","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,13]],"date-time":"2025-02-13T13:03:00Z","timestamp":1739451780000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/imr.13433"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12,26]]},"references-count":145,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,1]]}},"alternative-id":["10.1111\/imr.13433"],"URL":"https:\/\/doi.org\/10.1111\/imr.13433","archive":["Portico"],"relation":{},"ISSN":["0105-2896","1600-065X"],"issn-type":[{"value":"0105-2896","type":"print"},{"value":"1600-065X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,12,26]]},"assertion":[{"value":"2024-11-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-12-10","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-12-26","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e13433"}}