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Thus, a strong need exists for the development of a diverse panel of intervention strategies and modalities to combat malaria and achieve elimination and eradication goals. Deploying interventions that target bottlenecks in the transmission life cycle of the causative agent of malaria,\n                    <jats:italic>Plasmodium<\/jats:italic>\n                    parasites, is an attractive strategy. The development of highly potent antibody\u2010based biologics, including vaccines, can be greatly facilitated by an in\u2010depth molecular understanding of antibody\u2010epitope interactions. Here, we provide an overview of structurally characterized antibodies targeting lead vaccine candidates expressed during the bottlenecks of the\n                    <jats:italic>Plasmodium<\/jats:italic>\n                    life cycle which include the pre\u2010erythrocytic and sexual stages. The repeat region of the circumsporozoite protein (CSP), domain 1 of Pfs230 and domains 1 and 3 of Pfs48\/45 are critical\n                    <jats:italic>Plasmodium<\/jats:italic>\n                    regions targeted by the most potent antibodies at the two bottlenecks of transmission, with other promising targets emerging and requiring further characterization.\n                  <\/jats:p>","DOI":"10.1111\/imr.70001","type":"journal-article","created":{"date-parts":[[2025,2,5]],"date-time":"2025-02-05T07:54:29Z","timestamp":1738742069000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Targeting Bottlenecks in Malaria Transmission: Antibody\u2010Epitope Descriptions Guide the Design of Next\u2010Generation Biomedical Interventions"],"prefix":"10.1111","volume":"330","author":[{"given":"Randy","family":"Yoo","sequence":"first","affiliation":[{"name":"Program in Molecular Medicine The Hospital for Sick Children 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