{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T14:30:49Z","timestamp":1792161049416,"version":"4.4.0"},"reference-count":192,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,9,19]],"date-time":"2025-09-19T00:00:00Z","timestamp":1758240000000},"content-version":"vor","delay-in-days":18,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["2U19AI110483\u201011"],"award-info":[{"award-number":["2U19AI110483\u201011"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012051","name":"Lupus Research Alliance","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012051","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Immunological Reviews"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Owing to their participation in diverse infections and autoimmune diseases, B cells lacking expression of CD27, having low CD21 levels or expressing markers such as CD11c or T\u2010bet, have gained major prominence in the literature and are classified under the label of atypical B cells (AtB). Over time, different B cells (both of na\u00efve and memory derivation) have been included in the AtB category on the basis of the expression of the above markers alone or in different combinations. In this review, we argue that the term AtB is obsolete as multiple studies indicate that these cells are a normal component of human immune responses. We review evidence indicating that the actual nature, derivation, and function of different categories of AtB cells depend on the context of the specific immune response under study and propose that the AtB label should be abandoned in favor of more precise classifications. Finally, we proposed that given the degree of functional diversity of these cells, specific functional studies rather than historical descriptions should be used to understand their actual role under different conditions.<\/jats:p>","DOI":"10.1111\/imr.70058","type":"journal-article","created":{"date-parts":[[2025,9,19]],"date-time":"2025-09-19T08:29:13Z","timestamp":1758270553000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Human Atypical B Cells. An Overview"],"prefix":"10.1111","volume":"334","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4182-587X","authenticated-orcid":false,"given":"I\u00f1aki","family":"Sanz","sequence":"first","affiliation":[{"name":"Division of Rheumatology, Department of Medicine, Lowance Center for Human Immunology Emory University School of Medicine  Atlanta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,9,19]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.02458"},{"key":"e_1_2_12_3_1","doi-asserted-by":"crossref","unstructured":"V. R. C.Aguiar M. E.Franco N.Abdel Aziz et\u00a0al. \u201cA Multi\u2010Omics Resource of B Cell Activation Reveals Genetic Mechanisms for Immune\u2010Mediated Diseases \u201d MedRxiv 2025 https:\/\/doi.org\/10.1101\/2025.05.22.25328104.","DOI":"10.1101\/2025.05.22.25328104"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-024-02010-9"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2025.115472"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-39042-y"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-020-0743-0"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.adj4857"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-023-06708-y"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.abn1250"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2021.03.056"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-019-1922-8"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-019-0378-1"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-019-0398-x"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2020.06.013"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-024-50997-4"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-022-04527-1"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.3533"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2023.03.001"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2018.08.015"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/imr.13440"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-29450-x"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/cyto.b.20554"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.adh1315"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-019-1906-8"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/imr.12741"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2025.115557"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.abg8384"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI74351"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0901297"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20072683"},{"key":"e_1_2_12_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/imr.12809"},{"key":"e_1_2_12_33_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.00852"},{"key":"e_1_2_12_34_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-immunol-092419-031130"},{"key":"e_1_2_12_35_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2024624118"},{"key":"e_1_2_12_36_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-immunol-041015-055531"},{"key":"e_1_2_12_37_1","doi-asserted-by":"publisher","DOI":"10.1111\/imr.13068"},{"key":"e_1_2_12_38_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.635615"},{"key":"e_1_2_12_39_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.abh0891"},{"key":"e_1_2_12_40_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1700079"},{"key":"e_1_2_12_41_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri2524"},{"key":"e_1_2_12_42_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2009-09-243071"},{"key":"e_1_2_12_43_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-020-00814-z"},{"key":"e_1_2_12_44_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.41641"},{"key":"e_1_2_12_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clim.2004.05.010"},{"key":"e_1_2_12_46_1","doi-asserted-by":"publisher","DOI":"10.1078\/0171-2985-00198"},{"key":"e_1_2_12_47_1","doi-asserted-by":"publisher","DOI":"10.1093\/cei\/uxac103"},{"key":"e_1_2_12_48_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-03750-7"},{"key":"e_1_2_12_49_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.00032"},{"key":"e_1_2_12_50_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12016-025-09021-w"},{"key":"e_1_2_12_51_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.272.5258.54"},{"key":"e_1_2_12_52_1","doi-asserted-by":"publisher","DOI":"10.1038\/336070a0"},{"key":"e_1_2_12_53_1","doi-asserted-by":"publisher","DOI":"10.1038\/346749a0"},{"key":"e_1_2_12_54_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-065X.2003.00058.x"},{"key":"e_1_2_12_55_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1073924"},{"key":"e_1_2_12_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2019.07.001"},{"key":"e_1_2_12_57_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V89.4.1288"},{"key":"e_1_2_12_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2020.03.020"},{"key":"e_1_2_12_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2022.03.005"},{"key":"e_1_2_12_60_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.188.9.1679"},{"key":"e_1_2_12_61_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.aai8153"},{"key":"e_1_2_12_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2019.04.019"},{"key":"e_1_2_12_63_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2008-03-145979"},{"key":"e_1_2_12_64_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1501027"},{"key":"e_1_2_12_65_1","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.126492"},{"key":"e_1_2_12_66_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-024-75636-2"},{"key":"e_1_2_12_67_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.177.6.3728"},{"key":"e_1_2_12_68_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.178.10.6624"},{"key":"e_1_2_12_69_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20050879"},{"key":"e_1_2_12_70_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-019-0419-9"},{"key":"e_1_2_12_71_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.2000343"},{"key":"e_1_2_12_72_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.isci.2023.108496"},{"key":"e_1_2_12_73_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197310252891702"},{"key":"e_1_2_12_74_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V94.8.2800.420a01_2800_2808"},{"key":"e_1_2_12_75_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aax0904"},{"key":"e_1_2_12_76_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.aba6493"},{"key":"e_1_2_12_77_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-01-331462"},{"key":"e_1_2_12_78_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-01-330530"},{"key":"e_1_2_12_79_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1501209"},{"key":"e_1_2_12_80_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.181.2.1375"},{"key":"e_1_2_12_81_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1500055"},{"key":"e_1_2_12_82_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12026-012-8365-8"},{"key":"e_1_2_12_83_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellimm.2014.12.002"},{"key":"e_1_2_12_84_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI91250"},{"key":"e_1_2_12_85_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1601106"},{"key":"e_1_2_12_86_1","doi-asserted-by":"publisher","DOI":"10.1111\/imr.12380"},{"key":"e_1_2_12_87_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20221346"},{"key":"e_1_2_12_88_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-022-04642-z"},{"key":"e_1_2_12_89_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.adf8531"},{"key":"e_1_2_12_90_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-022-05273-0"},{"key":"e_1_2_12_91_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-022-01271-6"},{"key":"e_1_2_12_92_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2023.02.020"},{"key":"e_1_2_12_93_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.coi.2022.102227"},{"key":"e_1_2_12_94_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-022-04433-9"},{"key":"e_1_2_12_95_1","doi-asserted-by":"publisher","DOI":"10.15252\/emmm.202217341"},{"key":"e_1_2_12_96_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2021-220349"},{"key":"e_1_2_12_97_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20202001"},{"key":"e_1_2_12_98_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0801859"},{"key":"e_1_2_12_99_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2249.1995.tb02277.x"},{"key":"e_1_2_12_100_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780290606"},{"key":"e_1_2_12_101_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41581-023-00732-x"},{"key":"e_1_2_12_102_1","doi-asserted-by":"crossref","unstructured":"D. Y.Zhu D. P.Maurer C.Castrillon et\u00a0al. \u201cLupus\u2010Associated Innate Receptors Drive Extrafollicular Evolution of Autoreactive B Cells \u201d bioRxiv 2024 https:\/\/doi.org\/10.1101\/2024.01.09.574739.","DOI":"10.1101\/2024.01.09.574739"},{"key":"e_1_2_12_103_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-11-4284"},{"key":"e_1_2_12_104_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2023.112630"},{"key":"e_1_2_12_105_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.42157"},{"key":"e_1_2_12_106_1","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.126732"},{"key":"e_1_2_12_107_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.3175"},{"key":"e_1_2_12_108_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.adj4748"},{"key":"e_1_2_12_109_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1901340116"},{"key":"e_1_2_12_110_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-05772-7"},{"key":"e_1_2_12_111_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2018.06.074"},{"key":"e_1_2_12_112_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2021.02.015"},{"key":"e_1_2_12_113_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.abq3277"},{"key":"e_1_2_12_114_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1901175"},{"key":"e_1_2_12_115_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.201847641"},{"key":"e_1_2_12_116_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-018-0056-8"},{"key":"e_1_2_12_117_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2020.11.006"},{"key":"e_1_2_12_118_1","doi-asserted-by":"publisher","DOI":"10.1016\/bs.ai.2024.02.002"},{"key":"e_1_2_12_119_1","article-title":"Monoallelic IRF5 Deficiency in B Cells Prevents Murine Lupus","volume":"6","author":"Pellerin A.","year":"2021","journal-title":"JCI Insight"},{"key":"e_1_2_12_120_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11926-019-0803-3"},{"key":"e_1_2_12_121_1","doi-asserted-by":"publisher","DOI":"10.1093\/intimm\/dxy032"},{"key":"e_1_2_12_122_1","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/780436"},{"key":"e_1_2_12_123_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2011-200463"},{"key":"e_1_2_12_124_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-022-01810-6"},{"key":"e_1_2_12_125_1","doi-asserted-by":"crossref","unstructured":"K.Santos Guedes de Sa J.Silva R.Bayarri\u2010Olmos et\u00a0al. \u201cA Causal Link Between Autoantibodies and Neurological Symptoms in Long COVID \u201d medRxiv 2024 https:\/\/doi.org\/10.1101\/2024.06.18.24309100.","DOI":"10.1101\/2024.06.18.24309100"},{"key":"e_1_2_12_126_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-40012-7"},{"key":"e_1_2_12_127_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2020.08.025"},{"key":"e_1_2_12_128_1","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.127885"},{"key":"e_1_2_12_129_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awaf086"},{"issue":"1","key":"e_1_2_12_130_1","article-title":"Double\u2010Negative\u20102 B Cells Are the Major Synovial Plasma Cell Precursor in Rheumatoid Arthritis","volume":"14","author":"Wing E.","year":"2023","journal-title":"Frontiers in Immunology"},{"key":"e_1_2_12_131_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1301901"},{"key":"e_1_2_12_132_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2007.09.009"},{"key":"e_1_2_12_133_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1209372109"},{"key":"e_1_2_12_134_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2006.07.014"},{"key":"e_1_2_12_135_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2006.07.013"},{"key":"e_1_2_12_136_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.200737815"},{"key":"e_1_2_12_137_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2009.11.001"},{"key":"e_1_2_12_138_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.adg6427"},{"key":"e_1_2_12_139_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.22916"},{"key":"e_1_2_12_140_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2009.124313"},{"key":"e_1_2_12_141_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep03792"},{"key":"e_1_2_12_142_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.201646573"},{"key":"e_1_2_12_143_1","doi-asserted-by":"publisher","DOI":"10.1093\/ckj\/sfac152"},{"key":"e_1_2_12_144_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20050630"},{"key":"e_1_2_12_145_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2005070714"},{"key":"e_1_2_12_146_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2009.06.003"},{"key":"e_1_2_12_147_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1202195"},{"key":"e_1_2_12_148_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20122798"},{"key":"e_1_2_12_149_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1400098"},{"key":"e_1_2_12_150_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1401720"},{"key":"e_1_2_12_151_1","article-title":"NADPH Oxidase in B Cells and Macrophages Protects Against Murine Lupus by Regulation of TLR7","volume":"9","author":"Gordon R. A.","year":"2024","journal-title":"JCI Insight"},{"key":"e_1_2_12_152_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20230774"},{"key":"e_1_2_12_153_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41581-024-00890-6"},{"key":"e_1_2_12_154_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.adi9769"},{"key":"e_1_2_12_155_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-019-1612-6"},{"key":"e_1_2_12_156_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20211004"},{"key":"e_1_2_12_157_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20050914"},{"key":"e_1_2_12_158_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2005-07-2650"},{"key":"e_1_2_12_159_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20051696"},{"key":"e_1_2_12_160_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2010.07.012"},{"key":"e_1_2_12_161_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature09102"},{"key":"e_1_2_12_162_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M112.383000"},{"key":"e_1_2_12_163_1","doi-asserted-by":"publisher","DOI":"10.1080\/15548627.2015.1052206"},{"key":"e_1_2_12_164_1","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.169344"},{"key":"e_1_2_12_165_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2023.12.037"},{"key":"e_1_2_12_166_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1007050"},{"key":"e_1_2_12_167_1","doi-asserted-by":"crossref","unstructured":"C. D.Lovell N.Jiwrajka H. K.Amerman M. P.Cancro andM. C.Anguera \u201cXist Deletion in B Cells Results in Systemic Lupus Erythematosus Phenotypes \u201d bioRxiv 2024 https:\/\/doi.org\/10.1101\/2024.05.15.594175.","DOI":"10.1101\/2024.05.15.594175"},{"key":"e_1_2_12_168_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11926-003-0020-x"},{"key":"e_1_2_12_169_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.20430"},{"key":"e_1_2_12_170_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.34359"},{"key":"e_1_2_12_171_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.27233"},{"key":"e_1_2_12_172_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2410965"},{"key":"e_1_2_12_173_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-022-02017-5"},{"key":"e_1_2_12_174_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2308917"},{"key":"e_1_2_12_175_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard-2024-225727"},{"key":"e_1_2_12_176_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.24.021605.090517"},{"key":"e_1_2_12_177_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.coi.2018.10.008"},{"key":"e_1_2_12_178_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2016-01-694356"},{"key":"e_1_2_12_179_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2023325"},{"key":"e_1_2_12_180_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.coi.2019.09.005"},{"key":"e_1_2_12_181_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.00835"},{"key":"e_1_2_12_182_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.200737557"},{"key":"e_1_2_12_183_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2015.06.016"},{"key":"e_1_2_12_184_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard-2024-225785"},{"key":"e_1_2_12_185_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms251910845"},{"key":"e_1_2_12_186_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI180012"},{"key":"e_1_2_12_187_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMc2408786"},{"key":"e_1_2_12_188_1","doi-asserted-by":"publisher","DOI":"10.1177\/0961203315608254"},{"key":"e_1_2_12_189_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1505654"},{"key":"e_1_2_12_190_1","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.2025-0390.O010"},{"key":"e_1_2_12_191_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.berh.2023.101865"},{"key":"e_1_2_12_192_1","doi-asserted-by":"publisher","DOI":"10.1136\/lupus-2017-000226"},{"key":"e_1_2_12_193_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-024-01858-1"}],"container-title":["Immunological Reviews"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/imr.70058","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T05:21:47Z","timestamp":1758604907000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/imr.70058"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9]]},"references-count":192,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,9]]}},"alternative-id":["10.1111\/imr.70058"],"URL":"https:\/\/doi.org\/10.1111\/imr.70058","archive":["Portico"],"relation":{},"ISSN":["0105-2896","1600-065X"],"issn-type":[{"value":"0105-2896","type":"print"},{"value":"1600-065X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,9]]},"assertion":[{"value":"2025-08-03","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-08-08","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-09-19","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70058"}}