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The differentiation of IgE\u2010producing cells is unique, as there is a paucity of IgE memory B cells and most IgE\u2010expressing cells are plasma cells. High affinity IgE, however, is generated through sequential class switching from affinity\u2010matured non\u2010IgE memory B cells. Emerging studies have uncovered key features of the IgE response that are relevant to allergy development and persistence, including the existence of allergen\u2010specific high affinity type 2 IgG memory cells that are poised to switch to IgE, and long\u2010lived IgE plasma cells that reside in the bone marrow and secondary lymphoid organs. Here, we review how these processes sustain IgE memory and long\u2010term allergic sensitization despite the short lifespan of circulating IgE.<\/jats:p>","DOI":"10.1111\/imr.70089","type":"journal-article","created":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T05:48:45Z","timestamp":1767937725000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Type 2\n                    <scp>IgG<\/scp>\n                    Memory B Cells and Long\u2010Lived\n                    <scp>IgE<\/scp>\n                    Plasma Cells in the Persistence of Allergy"],"prefix":"10.1111","volume":"337","author":[{"given":"Mariana C. 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