{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T02:20:57Z","timestamp":1790130057094,"version":"4.0.1"},"reference-count":145,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,12,25]],"date-time":"2025-12-25T00:00:00Z","timestamp":1766620800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,12,25]],"date-time":"2025-12-25T00:00:00Z","timestamp":1766620800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["R01AI038339"],"award-info":[{"award-number":["R01AI038339"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["R01DK133393"],"award-info":[{"award-number":["R01DK133393"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Immunological Reviews"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>The intestinal immune system is constantly challenged to distinguish between innocuous dietary antigens, commensal microbiota and intestinal self\u2010antigens (self\u2010Ags) versus harmful pathogens and malignant cells. It resides in the intestinal wall itself, Peyer's patches (PPs) and the draining lymph nodes (LNs). Dendritic cells (DCs) are found in all of these structures and are professional antigen\u2010presenting cells (APCs) dictating and maintaining T cell fate. Here, we review how DCs contribute to immune homeostasis in the gastrointestinal system through multiple strategies: division in labor and strategic anatomical positioning between DC subtypes, plasticity and site\u2010specific functional adaptation. While these properties of DCs are likely not unique to the gastrointestinal tract, it is the site where we have learned most about how this DC network operates.<\/jats:p>","DOI":"10.1111\/imr.70090","type":"journal-article","created":{"date-parts":[[2025,12,25]],"date-time":"2025-12-25T10:11:27Z","timestamp":1766657487000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Dendritic Cells in the Gastrointestinal System: Division of Labor, Plasticity, and Niche\u2010Specific Adaptation"],"prefix":"10.1111","volume":"337","author":[{"given":"Yixuan D.","family":"Zhou","sequence":"first","affiliation":[{"name":"Department of Pathology University of Chicago  Chicago Illinois USA"},{"name":"Committee on Immunology University of Chicago  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Macy R.","family":"Komnick","sequence":"additional","affiliation":[{"name":"Department of Pathology University of Chicago  Chicago Illinois USA"},{"name":"Committee on Immunology University of Chicago  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2427-9873","authenticated-orcid":false,"given":"Daria","family":"Esterh\u00e1zy","sequence":"additional","affiliation":[{"name":"Department of Pathology University of Chicago  Chicago Illinois USA"},{"name":"Committee on Immunology University of Chicago  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,12,25]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1900710"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41385-021-00448-w"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.3408"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.02883"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2020.05.005"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/32588"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1164206"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/icb.2016.83"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-024-01745-9"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-019-0450-x"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.4110\/in.2015.15.1.1"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.174.5.2573"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-022-04866-z"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers14081976"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2015.04.017"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2019.09.035"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20221437"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.2679"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2011.08.013"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2020.04.005"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.4110\/in.2019.19.e6"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20130443"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2023.07.001"},{"key":"e_1_2_9_25_1","first-page":"1","article-title":"Functions of Dendritic Cells and Its Association With Intestinal Diseases","volume":"10","author":"Yang Z. J.","year":"2021","journal-title":"Cells"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20101387"},{"key":"e_1_2_9_27_1","first-page":"695","article-title":"Enhanced Phenotypic and Functional Maturation of Monocyte\u2010Derived Dendritic Cells From Patients With Active Crohn's Disease and Ulcerative Colitis","volume":"61","author":"Radwan P.","year":"2010","journal-title":"Journal of Physiology and Pharmacology"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/d41586-022-03368-2"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.coi.2025.102570"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20250760"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.adp0535"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2025.03.020"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-022-05309-5"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.ado5088"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586\u2010025\u201008982\u20104"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-022-05141-x"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41577-023-00906-5"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2009.08.010"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.201343740"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-019-1125-3"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2567.2006.02458.x"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2013.12.012"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1102901"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22158340"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.2768"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41577-019-0210-z"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.2147\/JIR.S407521"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aah5298"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2018.10.004"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.abd3774"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.1101\/2025.11.06.687030"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2008.06.017"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.4110\/in.2018.18.e5"},{"key":"e_1_2_9_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2013.01.009"},{"key":"e_1_2_9_55_1","doi-asserted-by":"publisher","DOI":"10.1111\/imm.13648"},{"key":"e_1_2_9_56_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20091925"},{"key":"e_1_2_9_57_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20052016"},{"key":"e_1_2_9_58_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20051100"},{"key":"e_1_2_9_59_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature11809"},{"key":"e_1_2_9_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2011.01.016"},{"key":"e_1_2_9_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.imbio.2016.07.013"},{"key":"e_1_2_9_62_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.536326"},{"key":"e_1_2_9_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2004.11.013"},{"key":"e_1_2_9_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2014.12.024"},{"key":"e_1_2_9_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2006.04.017"},{"key":"e_1_2_9_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2015.08.030"},{"key":"e_1_2_9_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2012.07.011"},{"key":"e_1_2_9_68_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2021.11.008"},{"key":"e_1_2_9_69_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mucimm.2024.03.004"},{"key":"e_1_2_9_70_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.02345"},{"key":"e_1_2_9_71_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2015.00001"},{"key":"e_1_2_9_72_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcdb.2014.11.012"},{"key":"e_1_2_9_73_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1208796109"},{"key":"e_1_2_9_74_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2012.03.009"},{"key":"e_1_2_9_75_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.191.4.669"},{"key":"e_1_2_9_76_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20091756"},{"key":"e_1_2_9_77_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.180.5.3019"},{"key":"e_1_2_9_78_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood\u20102001\u201011\u20100017"},{"key":"e_1_2_9_79_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2249.1999.00991.x"},{"key":"e_1_2_9_80_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.711329"},{"key":"e_1_2_9_81_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2024.05.007"},{"key":"e_1_2_9_82_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI84431"},{"key":"e_1_2_9_83_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.202401024"},{"key":"e_1_2_9_84_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2012.08.026"},{"key":"e_1_2_9_85_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2010.09.039"},{"key":"e_1_2_9_86_1","doi-asserted-by":"publisher","DOI":"10.1038\/mi.2015.77"},{"key":"e_1_2_9_87_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2016.08.015"},{"key":"e_1_2_9_88_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2017.02.019"},{"key":"e_1_2_9_89_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2023.07.008"},{"key":"e_1_2_9_90_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2024.114296"},{"key":"e_1_2_9_91_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2013.03.009"},{"key":"e_1_2_9_92_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-25115-3"},{"key":"e_1_2_9_93_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.181.4.2277"},{"key":"e_1_2_9_94_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-06423-7"},{"key":"e_1_2_9_95_1","doi-asserted-by":"publisher","DOI":"10.1113\/expphysiol.1956.sp001195"},{"key":"e_1_2_9_96_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2024.114311"},{"key":"e_1_2_9_97_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.189.3.587"},{"key":"e_1_2_9_98_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1521-4141(199806)28:06<2045::AID-IMMU2045>3.0.CO;2-8"},{"key":"e_1_2_9_99_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1521-4141(199802)28:02<687::AID-IMMU687>3.0.CO;2-N"},{"key":"e_1_2_9_100_1","doi-asserted-by":"publisher","DOI":"10.1006\/cimm.1999.1555"},{"key":"e_1_2_9_101_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(00)00045-5"},{"key":"e_1_2_9_102_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2020.04.022"},{"key":"e_1_2_9_103_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1164206"},{"key":"e_1_2_9_104_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2017.04.003"},{"key":"e_1_2_9_105_1","doi-asserted-by":"publisher","DOI":"10.1038\/mi.2016.79"},{"key":"e_1_2_9_106_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2012.08.016"},{"key":"e_1_2_9_107_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2023.06.022"},{"key":"e_1_2_9_108_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.02062-17"},{"key":"e_1_2_9_109_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2021.10.002"},{"key":"e_1_2_9_110_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2020.03.048"},{"key":"e_1_2_9_111_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2019.10.003"},{"key":"e_1_2_9_112_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2020.02.008"},{"key":"e_1_2_9_113_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2017.06.062"},{"key":"e_1_2_9_114_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni805"},{"key":"e_1_2_9_115_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2020.10.001"},{"key":"e_1_2_9_116_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-immunol-101819-025146"},{"key":"e_1_2_9_117_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.abh0707"},{"key":"e_1_2_9_118_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms15820"},{"key":"e_1_2_9_119_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2017.00861"},{"key":"e_1_2_9_120_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2018.12.020"},{"key":"e_1_2_9_121_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.2200204"},{"key":"e_1_2_9_122_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2014.03.005"},{"key":"e_1_2_9_123_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2009.09.033"},{"key":"e_1_2_9_124_1","doi-asserted-by":"publisher","DOI":"10.1038\/mi.2015.64"},{"key":"e_1_2_9_125_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41575-023-00768-1"},{"key":"e_1_2_9_126_1","doi-asserted-by":"publisher","DOI":"10.1038\/mi.2015.48"},{"key":"e_1_2_9_127_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.616020"},{"key":"e_1_2_9_128_1","doi-asserted-by":"publisher","DOI":"10.1038\/mi.2015.50"},{"key":"e_1_2_9_129_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.01897"},{"key":"e_1_2_9_130_1","doi-asserted-by":"publisher","DOI":"10.1038\/mi.2016.114"},{"key":"e_1_2_9_131_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2016.05.047"},{"key":"e_1_2_9_132_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature09849"},{"key":"e_1_2_9_133_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2022.05.015"},{"key":"e_1_2_9_134_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41423-021-00753-1"},{"key":"e_1_2_9_135_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2022.05.013"},{"key":"e_1_2_9_136_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-05470-4"},{"key":"e_1_2_9_137_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1014465107"},{"key":"e_1_2_9_138_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-023-35097-5"},{"key":"e_1_2_9_139_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2024.114490"},{"key":"e_1_2_9_140_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aac5560"},{"key":"e_1_2_9_141_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mucimm.2024.06.006"},{"key":"e_1_2_9_142_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-020-2193-0"},{"key":"e_1_2_9_143_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2021.109726"},{"key":"e_1_2_9_144_1","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/2636701"},{"key":"e_1_2_9_145_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20122762"},{"key":"e_1_2_9_146_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20080414"}],"container-title":["Immunological Reviews"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/imr.70090","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/imr.70090","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/imr.70090","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T04:15:57Z","timestamp":1768968957000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/imr.70090"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,25]]},"references-count":145,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["10.1111\/imr.70090"],"URL":"https:\/\/doi.org\/10.1111\/imr.70090","archive":["Portico"],"relation":{},"ISSN":["0105-2896","1600-065X"],"issn-type":[{"value":"0105-2896","type":"print"},{"value":"1600-065X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,25]]},"assertion":[{"value":"2025-09-07","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-12-08","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-12-25","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70090"}}