{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T03:57:07Z","timestamp":1792468627240,"version":"4.5.0"},"reference-count":193,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,12,29]],"date-time":"2025-12-29T00:00:00Z","timestamp":1766966400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,12,29]],"date-time":"2025-12-29T00:00:00Z","timestamp":1766966400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100005189","name":"Estonian Research Competency Council","doi-asserted-by":"publisher","award":["PRG2011"],"award-info":[{"award-number":["PRG2011"]}],"id":[{"id":"10.13039\/501100005189","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005189","name":"Estonian Research Competency Council","doi-asserted-by":"publisher","award":["PRG377"],"award-info":[{"award-number":["PRG377"]}],"id":[{"id":"10.13039\/501100005189","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Immunological Reviews"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Central tolerance, established in the thymus, ensures T cells are nonreactive to self\u2010antigens while maintaining a functional immune repertoire. Medullary thymic epithelial cells (mTECs) and thymic dendritic cells (DCs) play a crucial role in this mechanism by orchestrating the selection and deletion of autoreactive thymocytes, a process heavily influenced by the Autoimmune Regulator (AIRE). AIRE promotes the promiscuous expression of tissue\u2010restricted antigens (TRAs) in mTECs, enabling the elimination of self\u2010reactive T cells and the differentiation of regulatory T cells (Tregs). Studies on the role of AIRE in transcriptional regulation and nuclear body localization have significantly advanced our understanding of its mechanisms, revealing protein interactions with chromatin\u2010associated complexes that facilitate broad transcriptomic complexity in mTECs. However, the discovery of neutralizing type 1 interferon (T1 IFN) autoantibodies in APECED patients, alongside recently identified AIRE\u2010induced IFN signals in the thymus, suggests that AIRE's influence extends beyond its classical function in negative selection, potentially playing a broader role in thymic homeostasis via inflammatory signals. This review discusses recent advances in understanding AIRE's complexity, its role in transcriptional regulation and nuclear location, insights from studies in human APECED patients and rodent models, and the emerging concept of an IFN\u2010mediated tonic inflammatory signal in the thymus.<\/jats:p>","DOI":"10.1111\/imr.70091","type":"journal-article","created":{"date-parts":[[2025,12,30]],"date-time":"2025-12-30T04:06:27Z","timestamp":1767067587000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["AIRE's Complex Role Beyond Promiscuous Gene Expression"],"prefix":"10.1111","volume":"337","author":[{"given":"P\u00e4rt","family":"Peterson","sequence":"first","affiliation":[{"name":"Institute of Biomedicine and Translational Medicine University of Tartu  Tartu Estonia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,12,29]]},"reference":[{"key":"e_1_2_19_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri2136"},{"key":"e_1_2_19_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri2450"},{"key":"e_1_2_19_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41577-023-00911-8"},{"key":"e_1_2_19_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-023-01469-2"},{"key":"e_1_2_19_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri1436"},{"key":"e_1_2_19_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri3667"},{"key":"e_1_2_19_8_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.25.022106.141532"},{"key":"e_1_2_19_9_1","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.1999.0308"},{"key":"e_1_2_19_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/1521-4141(200007)30:7<1884::AID-IMMU1884>3.0.CO;2-P"},{"key":"e_1_2_19_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni723"},{"key":"e_1_2_19_12_1","doi-asserted-by":"publisher","DOI":"10.1101\/gr.171645.113"},{"key":"e_1_2_19_13_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13059-016-1079-9"},{"key":"e_1_2_19_14_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pcbi.1000598"},{"key":"e_1_2_19_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2015.10.013"},{"key":"e_1_2_19_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gdata.2015.08.004"},{"key":"e_1_2_19_17_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2012.00019"},{"key":"e_1_2_19_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-018-0345-2"},{"key":"e_1_2_19_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-018-0346-1"},{"key":"e_1_2_19_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2022.05.018"},{"key":"e_1_2_19_21_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-genet-080320-040045"},{"key":"e_1_2_19_22_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0707486105"},{"key":"e_1_2_19_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/emboj.2009.212"},{"key":"e_1_2_19_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.200636962"},{"key":"e_1_2_19_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng0397-293"},{"key":"e_1_2_19_26_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20061864"},{"key":"e_1_2_19_27_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI44583"},{"key":"e_1_2_19_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature06066"},{"key":"e_1_2_19_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-024-07079-8"},{"key":"e_1_2_19_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41577-024-01076-8"},{"key":"e_1_2_19_31_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.71578"},{"key":"e_1_2_19_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2018.04.007"},{"key":"e_1_2_19_33_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-023-06512-8"},{"key":"e_1_2_19_34_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41577-019-0238-0"},{"key":"e_1_2_19_35_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-cellbio-112122-023316"},{"key":"e_1_2_19_36_1","doi-asserted-by":"publisher","DOI":"10.4103\/2229-516X.96791"},{"key":"e_1_2_19_37_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20080046"},{"key":"e_1_2_19_38_1","doi-asserted-by":"publisher","DOI":"10.1097\/JTO.0b013e3181f1f63f"},{"key":"e_1_2_19_39_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.635569"},{"key":"e_1_2_19_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2015.11.056"},{"key":"e_1_2_19_41_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0806616105"},{"key":"e_1_2_19_42_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0808069105"},{"key":"e_1_2_19_43_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddp433"},{"key":"e_1_2_19_44_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0502670102"},{"key":"e_1_2_19_45_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20050471"},{"key":"e_1_2_19_46_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.3246"},{"key":"e_1_2_19_47_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.3247"},{"key":"e_1_2_19_48_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.3675"},{"key":"e_1_2_19_49_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2110991118"},{"key":"e_1_2_19_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2009.12.030"},{"key":"e_1_2_19_51_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gks933"},{"key":"e_1_2_19_52_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1323535111"},{"key":"e_1_2_19_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-5699(98)01293-6"},{"key":"e_1_2_19_54_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.gene.6363929"},{"key":"e_1_2_19_55_1","doi-asserted-by":"publisher","DOI":"10.1038\/embor.2008.11"},{"key":"e_1_2_19_56_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0808470105"},{"key":"e_1_2_19_57_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkp166"},{"key":"e_1_2_19_58_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1222023110"},{"key":"e_1_2_19_59_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1119351109"},{"key":"e_1_2_19_60_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkr527"},{"key":"e_1_2_19_61_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.01085-07"},{"key":"e_1_2_19_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2022.12.006"},{"key":"e_1_2_19_63_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1512081112"},{"key":"e_1_2_19_64_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.RA117.001518"},{"key":"e_1_2_19_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamcr.2007.09.003"},{"key":"e_1_2_19_66_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc2607"},{"key":"e_1_2_19_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2022.167858"},{"key":"e_1_2_19_68_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.06359-11"},{"key":"e_1_2_19_69_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M116.764704"},{"key":"e_1_2_19_70_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrm.2016.111"},{"key":"e_1_2_19_71_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-biochem-060815-014908"},{"key":"e_1_2_19_72_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-genet-120213-092015"},{"key":"e_1_2_19_73_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-024-07169-7"},{"key":"e_1_2_19_74_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M707211200"},{"key":"e_1_2_19_75_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M400702200"},{"key":"e_1_2_19_76_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M008322200"},{"key":"e_1_2_19_77_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.20.16.6138-6146.2000"},{"key":"e_1_2_19_78_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng1780"},{"key":"e_1_2_19_79_1","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/526518"},{"key":"e_1_2_19_80_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2020.04.007"},{"key":"e_1_2_19_81_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/8.2.259"},{"key":"e_1_2_19_82_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2005.05.187"},{"key":"e_1_2_19_83_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M908944199"},{"key":"e_1_2_19_84_1","doi-asserted-by":"publisher","DOI":"10.1002\/humu.20224"},{"key":"e_1_2_19_85_1","doi-asserted-by":"publisher","DOI":"10.1002\/humu.20003"},{"key":"e_1_2_19_86_1","doi-asserted-by":"publisher","DOI":"10.1177\/002215540104900207"},{"key":"e_1_2_19_87_1","doi-asserted-by":"publisher","DOI":"10.1086\/302765"},{"key":"e_1_2_19_88_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/11.26.3299"},{"key":"e_1_2_19_89_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/8.2.277"},{"key":"e_1_2_19_90_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M400702200"},{"key":"e_1_2_19_91_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexcr.2012.04.013"},{"key":"e_1_2_19_92_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-15448-w"},{"key":"e_1_2_19_93_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.01979-15"},{"key":"e_1_2_19_94_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M109.037747"},{"key":"e_1_2_19_95_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molimm.2005.02.018"},{"key":"e_1_2_19_96_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tcb.2023.10.012"},{"key":"e_1_2_19_97_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tibs.2022.02.002"},{"key":"e_1_2_19_98_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.80156"},{"key":"e_1_2_19_99_1","doi-asserted-by":"publisher","DOI":"10.1074\/mcp.RA117.000447"},{"issue":"12","key":"e_1_2_19_100_1","first-page":"2027","article-title":"Induction of the PML Protein by Interferons in Normal and APL Cells","volume":"9","author":"Chelbi\u2010Alix M. K.","year":"1995","journal-title":"Leukemia"},{"key":"e_1_2_19_101_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.23.17.6174-6186.2003"},{"key":"e_1_2_19_102_1","doi-asserted-by":"publisher","DOI":"10.1177\/1947601911402682"},{"key":"e_1_2_19_103_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2012-05-432104"},{"key":"e_1_2_19_104_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm8091408"},{"key":"e_1_2_19_105_1","doi-asserted-by":"publisher","DOI":"10.1074\/mcp.M114.047068"},{"key":"e_1_2_19_106_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng1297-393"},{"key":"e_1_2_19_107_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng1297-399"},{"key":"e_1_2_19_108_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni906"},{"key":"e_1_2_19_109_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1075958"},{"key":"e_1_2_19_110_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2005.07.005"},{"key":"e_1_2_19_111_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2016.02.009"},{"key":"e_1_2_19_112_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1233913"},{"key":"e_1_2_19_113_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni1444"},{"key":"e_1_2_19_114_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0507014102"},{"key":"e_1_2_19_115_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aaa7017"},{"key":"e_1_2_19_116_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.178.2.1208"},{"key":"e_1_2_19_117_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2010.07.008"},{"key":"e_1_2_19_118_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2005.08.036"},{"key":"e_1_2_19_119_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.aav6778"},{"key":"e_1_2_19_120_1","doi-asserted-by":"publisher","DOI":"10.1111\/sji.12586"},{"key":"e_1_2_19_121_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.isci.2024.109610"},{"key":"e_1_2_19_122_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199006283222601"},{"key":"e_1_2_19_123_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2005-2611"},{"key":"e_1_2_19_124_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10875-015-0176-y"},{"key":"e_1_2_19_125_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2796.2009.02090.x"},{"key":"e_1_2_19_126_1","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.88782"},{"key":"e_1_2_19_127_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.609253"},{"key":"e_1_2_19_128_1","doi-asserted-by":"publisher","DOI":"10.1111\/imr.12714"},{"key":"e_1_2_19_129_1","doi-asserted-by":"publisher","DOI":"10.1111\/sji.70021"},{"key":"e_1_2_19_130_1","doi-asserted-by":"publisher","DOI":"10.1530\/EC-12-0074"},{"issue":"2","key":"e_1_2_19_131_1","first-page":"323","article-title":"Autoantibodies to Cytochrome P450 Enzymes P450scc, P450c17, and P450c21 in Autoimmune Polyglandular Disease Types I and II and in Isolated Addison's Disease","volume":"78","author":"Uibo R.","year":"1994","journal-title":"Journal of Clinical Endocrinology and Metabolism"},{"key":"e_1_2_19_132_1","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(92)91894-E"},{"issue":"2","key":"e_1_2_19_133_1","first-page":"379","article-title":"Clinical and Immunological Characteristics of Autoimmune Addison Disease: A Nationwide Swedish Multicenter Study","volume":"102","author":"Dalin F.","year":"2017","journal-title":"Journal of Clinical Endocrinology and Metabolism"},{"key":"e_1_2_19_134_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI116843"},{"key":"e_1_2_19_135_1","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(92)91829-W"},{"key":"e_1_2_19_136_1","doi-asserted-by":"publisher","DOI":"10.2337\/diab.43.1.161"},{"key":"e_1_2_19_137_1","doi-asserted-by":"publisher","DOI":"10.1530\/eje.0.1430497"},{"key":"e_1_2_19_138_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(97)11050-9"},{"key":"e_1_2_19_139_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-5793(97)00797-7"},{"issue":"1","key":"e_1_2_19_140_1","first-page":"147","article-title":"Autoantibodies Against Aromatic L\u2010Amino Acid Decarboxylase in Autoimmune Polyendocrine Syndrome Type I","volume":"82","author":"Husebye E. S.","year":"1997","journal-title":"Journal of Clinical Endocrinology and Metabolism"},{"key":"e_1_2_19_141_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0706487"},{"key":"e_1_2_19_142_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2016.06.024"},{"key":"e_1_2_19_143_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2017.00976"},{"key":"e_1_2_19_144_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1401068"},{"key":"e_1_2_19_145_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.0030289"},{"key":"e_1_2_19_146_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10875-013-9938-6"},{"key":"e_1_2_19_147_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2008-03-144634"},{"key":"e_1_2_19_148_1","doi-asserted-by":"publisher","DOI":"10.1111\/cei.12024"},{"key":"e_1_2_19_149_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clim.2008.07.002"},{"key":"e_1_2_19_150_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clim.2021.108851"},{"key":"e_1_2_19_151_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.201041253"},{"key":"e_1_2_19_152_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2249.2008.03739.x"},{"key":"e_1_2_19_153_1","doi-asserted-by":"publisher","DOI":"10.1097\/JTO.0b013e3181f1f63f"},{"key":"e_1_2_19_154_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddr247"},{"key":"e_1_2_19_155_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41577-023-00933-2"},{"key":"e_1_2_19_156_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.abe3454"},{"key":"e_1_2_19_157_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-023-06717-x"},{"key":"e_1_2_19_158_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2024.1327784"},{"key":"e_1_2_19_159_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.abl4340"},{"key":"e_1_2_19_160_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2200413119"},{"key":"e_1_2_19_161_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.abd4585"},{"key":"e_1_2_19_162_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20210554"},{"key":"e_1_2_19_163_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20091669"},{"key":"e_1_2_19_164_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20091983"},{"key":"e_1_2_19_165_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.00838"},{"key":"e_1_2_19_166_1","doi-asserted-by":"publisher","DOI":"10.1002\/iid3.109"},{"key":"e_1_2_19_167_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2006.06.001"},{"key":"e_1_2_19_168_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri2136-c1"},{"key":"e_1_2_19_169_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20050693"},{"key":"e_1_2_19_170_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0902434"},{"key":"e_1_2_19_171_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0700259104"},{"key":"e_1_2_19_172_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.174.4.1862"},{"key":"e_1_2_19_173_1","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.93265"},{"key":"e_1_2_19_174_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20131889"},{"key":"e_1_2_19_175_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0035005"},{"key":"e_1_2_19_176_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.201747209"},{"key":"e_1_2_19_177_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1701318"},{"key":"e_1_2_19_178_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI156507"},{"key":"e_1_2_19_179_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20241403"},{"key":"e_1_2_19_180_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2012.01.011"},{"key":"e_1_2_19_181_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.3419"},{"key":"e_1_2_19_182_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20161451"},{"key":"e_1_2_19_183_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0024252"},{"key":"e_1_2_19_184_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.173.12.7269"},{"key":"e_1_2_19_185_1","doi-asserted-by":"publisher","DOI":"10.1093\/intimm\/dxy073"},{"key":"e_1_2_19_186_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0804277"},{"key":"e_1_2_19_187_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1203086"},{"key":"e_1_2_19_188_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.adp1139"},{"key":"e_1_2_19_189_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41577-022-00751-y"},{"key":"e_1_2_19_190_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.coi.2023.102389"},{"key":"e_1_2_19_191_1","doi-asserted-by":"publisher","DOI":"10.1111\/imr.70038"},{"key":"e_1_2_19_192_1","doi-asserted-by":"publisher","DOI":"10.1093\/jimmun\/vkaf048"},{"key":"e_1_2_19_193_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0024972"},{"key":"e_1_2_19_194_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature03886"}],"container-title":["Immunological Reviews"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/imr.70091","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/imr.70091","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/imr.70091","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T04:15:43Z","timestamp":1768968943000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/imr.70091"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,29]]},"references-count":193,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["10.1111\/imr.70091"],"URL":"https:\/\/doi.org\/10.1111\/imr.70091","archive":["Portico"],"relation":{},"ISSN":["0105-2896","1600-065X"],"issn-type":[{"value":"0105-2896","type":"print"},{"value":"1600-065X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,29]]},"assertion":[{"value":"2025-02-28","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-12-13","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-12-29","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70091"}}