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In particular, the distinct roles of antigen\u2010specific T cell mechanisms are emerging as critical determinants across a broad spectrum of conditions, ranging from atherosclerosis, myocardial infarction (MI), heart failure (HF), and myocarditis. Because these T cell responses are fundamentally driven by antigen recognition of cardiovascular antigens, understanding T cell clonal dynamics via accessing T cell receptor (TCR) repertoires might provide valuable mechanistic insights for developing targeted diagnostic and therapeutic immunomodulatory approaches in cardiology. In this review, we discuss T cell\u2010dependent mechanisms and TCR clonal dynamics across various CVD. Moreover, by curating public bulk and single\u2010cell TCR datasets across different etiologies, we present a first\u2010in\u2010class adaptive immune receptor database in cardiovascular diseases (CVD\u2010TCR database). The discussions and resources herein presented seek to promote an integrated understanding of tissue\u2010specific immune mechanisms across different CVD, facilitate the identification of shared clonotypes and motifs, and provide a framework for computational modeling of TCR repertoires across the CVD spectrum.<\/jats:p>","DOI":"10.1111\/imr.70125","type":"journal-article","created":{"date-parts":[[2026,4,19]],"date-time":"2026-04-19T11:14:36Z","timestamp":1776597276000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["T Cell Receptor Repertoires Across the Continuum of Vascular, Myocardial, and Age\u2010Related Diseases"],"prefix":"10.1111","volume":"339","author":[{"given":"Leon","family":"Richter","sequence":"first","affiliation":[{"name":"Department of Internal Medicine I University Hospital W\u00fcrzburg  W\u00fcrzburg Germany"},{"name":"Comprehensive Heart Failure Centre University Hospital W\u00fcrzburg  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