{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T09:01:52Z","timestamp":1790154112556,"version":"4.0.1"},"reference-count":176,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T00:00:00Z","timestamp":1789603200000},"content-version":"vor","delay-in-days":16,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100000265","name":"Medical Research Council","doi-asserted-by":"publisher","award":["CC2080"],"award-info":[{"award-number":["CC2080"]}],"id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["CC2080"],"award-info":[{"award-number":["CC2080"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000289","name":"Cancer Research UK","doi-asserted-by":"publisher","award":["CC2080"],"award-info":[{"award-number":["CC2080"]}],"id":[{"id":"10.13039\/501100000289","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010438","name":"Francis Crick Institute","doi-asserted-by":"publisher","award":["CC2080"],"award-info":[{"award-number":["CC2080"]}],"id":[{"id":"10.13039\/100010438","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Immunological Reviews"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>BAFF and APRIL are TNF superfamily proteins that bind to BAFFR, TACI and BCMA, members of the TNF receptor superfamily. These proteins have both unique and overlapping roles in B cell development and survival and are major therapeutic targets for antibody\u2010 and B\u2010cell\u2010driven pathologies. BAFF and BAFFR are required for development and survival of follicular and marginal zone (MZ) B cells, whereas BAFF and APRIL acting through TACI and BCMA support plasma cell survival. TACI and BCMA can both be cleaved to generate soluble decoy receptors binding to BAFF or APRIL, forming feedback circuits. Thus, loss of TACI leads to an increase in BAFF, resulting in B cell hyperplasia. Recent work showed that TACI is required for MZ B cell development, a finding that has implications for understanding immune dysfunction in humans. Both monoallelic and biallelic loss\u2010of\u2010function TACI mutations result in immunodeficiency, potentially due to impaired MZ B cell function. Paradoxically, monoallelic TACI mutations predispose to autoimmunity. We propose this may be due to increased BAFF levels which promote selection of self\u2010reactive B cell clones into the mature B cell pool, particularly the MZ B cell compartment. A deeper understanding of this ligand\u2010receptor system is essential for effective therapeutic targeting.<\/jats:p>","DOI":"10.1111\/imr.70170","type":"journal-article","created":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T05:23:08Z","timestamp":1789708988000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["<scp>BAFF<\/scp>\n                    and\n                    <scp>APRIL<\/scp>\n                    Receptors in B Cell Immunity and Autoimmunity"],"prefix":"10.1111","volume":"342","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9622-664X","authenticated-orcid":false,"given":"Daisy H.","family":"Luff","sequence":"first","affiliation":[{"name":"The Francis Crick Institute  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edina","family":"Schweighoffer","sequence":"additional","affiliation":[{"name":"The Francis Crick Institute  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2439-0798","authenticated-orcid":false,"given":"Victor L. J.","family":"Tybulewicz","sequence":"additional","affiliation":[{"name":"The Francis Crick Institute  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,17]]},"reference":[{"key":"e_1_2_19_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.smim.2006.04.006"},{"key":"e_1_2_19_3_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.189.11.1747"},{"key":"e_1_2_19_4_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.285.5425.260"},{"key":"e_1_2_19_5_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2007-09-110874"},{"key":"e_1_2_19_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.201040591"},{"key":"e_1_2_19_7_1","doi-asserted-by":"publisher","DOI":"10.1006\/jmbi.2001.5296"},{"key":"e_1_2_19_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-03323-8"},{"key":"e_1_2_19_9_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2020.577662"},{"key":"e_1_2_19_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/embo\u2010reports\/kve198"},{"key":"e_1_2_19_11_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20042309"},{"key":"e_1_2_19_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.cdd.4401647"},{"key":"e_1_2_19_13_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.169.8.4314"},{"key":"e_1_2_19_14_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M115.661405"},{"key":"e_1_2_19_15_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M411714200"},{"key":"e_1_2_19_16_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M601553200"},{"key":"e_1_2_19_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-025-61271-6"},{"key":"e_1_2_19_18_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1402070"},{"key":"e_1_2_19_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms8333"},{"key":"e_1_2_19_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2017.02.005"},{"key":"e_1_2_19_21_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2003-08-2694"},{"key":"e_1_2_19_22_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20021343"},{"key":"e_1_2_19_23_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20150577"},{"key":"e_1_2_19_24_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1901120"},{"key":"e_1_2_19_25_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20030789"},{"key":"e_1_2_19_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.2965"},{"key":"e_1_2_19_27_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-01-332940"},{"key":"e_1_2_19_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.1981"},{"key":"e_1_2_19_29_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2009-12-259457"},{"key":"e_1_2_19_30_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-11-4512"},{"key":"e_1_2_19_31_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.172.2.762"},{"key":"e_1_2_19_32_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0005456"},{"key":"e_1_2_19_33_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20191393"},{"key":"e_1_2_19_34_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20251308"},{"key":"e_1_2_19_35_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.179.11.7276"},{"key":"e_1_2_19_36_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2025.1539773"},{"key":"e_1_2_19_37_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-12-2422"},{"key":"e_1_2_19_38_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1061964"},{"key":"e_1_2_19_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(01)00183-2"},{"key":"e_1_2_19_40_1","doi-asserted-by":"publisher","DOI":"10.1038\/35010115"},{"key":"e_1_2_19_41_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI26385"},{"key":"e_1_2_19_42_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.190.11.1697"},{"key":"e_1_2_19_43_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.27189"},{"key":"e_1_2_19_44_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.34400"},{"key":"e_1_2_19_45_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.173.4.2245"},{"key":"e_1_2_19_46_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.173.4.2331"},{"key":"e_1_2_19_47_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.180.6.3655"},{"key":"e_1_2_19_48_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0807841105"},{"key":"e_1_2_19_49_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20191167"},{"key":"e_1_2_19_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2022.111019"},{"key":"e_1_2_19_51_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M413634200"},{"key":"e_1_2_19_52_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni842"},{"key":"e_1_2_19_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2008.01.009"},{"key":"e_1_2_19_54_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1401514"},{"key":"e_1_2_19_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2013.10.022"},{"key":"e_1_2_19_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2012.11.015"},{"key":"e_1_2_19_57_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20060990"},{"key":"e_1_2_19_58_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0805460105"},{"key":"e_1_2_19_59_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2007-03-077222"},{"key":"e_1_2_19_60_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.179.6.3872"},{"key":"e_1_2_19_61_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.1666"},{"key":"e_1_2_19_62_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20142127"},{"key":"e_1_2_19_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(01)00130-3"},{"key":"e_1_2_19_64_1","doi-asserted-by":"publisher","DOI":"10.1038\/89790"},{"key":"e_1_2_19_65_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-017-01602-4"},{"key":"e_1_2_19_66_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1102321"},{"key":"e_1_2_19_67_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2025.1593338"},{"key":"e_1_2_19_68_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.19.1.595"},{"key":"e_1_2_19_69_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri.2017.19"},{"key":"e_1_2_19_70_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.151.9.4431"},{"key":"e_1_2_19_71_1","doi-asserted-by":"publisher","DOI":"10.1111\/imr.12818"},{"key":"e_1_2_19_72_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2005.08.007"},{"key":"e_1_2_19_73_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1900175"},{"key":"e_1_2_19_74_1","doi-asserted-by":"publisher","DOI":"10.1016\/1074-7613(95)90157-4"},{"key":"e_1_2_19_75_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0804295"},{"key":"e_1_2_19_76_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(00)80157-0"},{"key":"e_1_2_19_77_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(02)00426-0"},{"key":"e_1_2_19_78_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1073560"},{"key":"e_1_2_19_79_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-05674-8"},{"key":"e_1_2_19_80_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20180617"},{"key":"e_1_2_19_81_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.173.10.6179"},{"key":"e_1_2_19_82_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(01)00129-7"},{"key":"e_1_2_19_83_1","doi-asserted-by":"publisher","DOI":"10.1093\/intimm\/dxab097"},{"key":"e_1_2_19_84_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1402739111"},{"key":"e_1_2_19_85_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1401275"},{"key":"e_1_2_19_86_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.200939817"},{"key":"e_1_2_19_87_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2023.112378"},{"key":"e_1_2_19_88_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1013168108"},{"key":"e_1_2_19_89_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2007-08-109769"},{"key":"e_1_2_19_90_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M003918200"},{"key":"e_1_2_19_91_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.2685"},{"key":"e_1_2_19_92_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.186.11.1897"},{"key":"e_1_2_19_93_1","doi-asserted-by":"publisher","DOI":"10.1385\/IR:22:2-3:281"},{"key":"e_1_2_19_94_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2009-09-241638"},{"key":"e_1_2_19_95_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(03)00111-0"},{"key":"e_1_2_19_96_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-12-325944"},{"key":"e_1_2_19_97_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2012-06-435099"},{"key":"e_1_2_19_98_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1103102"},{"key":"e_1_2_19_99_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-12-395319"},{"key":"e_1_2_19_100_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-21359-1"},{"key":"e_1_2_19_101_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1800393"},{"key":"e_1_2_19_102_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1600017"},{"key":"e_1_2_19_103_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri799"},{"key":"e_1_2_19_104_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1521-4141(199910)29:10<3285::AID-IMMU3285>3.0.CO;2-P"},{"key":"e_1_2_19_105_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.200838432"},{"key":"e_1_2_19_106_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20062567"},{"key":"e_1_2_19_107_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI0215034"},{"key":"e_1_2_19_108_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.24.3.997-1006.2004"},{"key":"e_1_2_19_109_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI0214121"},{"key":"e_1_2_19_110_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2004.05.010"},{"key":"e_1_2_19_111_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-01-0346"},{"key":"e_1_2_19_112_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.98.3.1166"},{"key":"e_1_2_19_113_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-06089-1"},{"key":"e_1_2_19_114_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20070447"},{"key":"e_1_2_19_115_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20132203"},{"key":"e_1_2_19_116_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20202001"},{"key":"e_1_2_19_117_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng1600"},{"key":"e_1_2_19_118_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2016.07.028"},{"key":"e_1_2_19_119_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.ade1413"},{"key":"e_1_2_19_120_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.175.5.3262"},{"key":"e_1_2_19_121_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41577-024-00991-0"},{"key":"e_1_2_19_122_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1200386109"},{"key":"e_1_2_19_123_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2404309121"},{"key":"e_1_2_19_124_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-025-62530-2"},{"key":"e_1_2_19_125_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-05-353961"},{"key":"e_1_2_19_126_1","doi-asserted-by":"publisher","DOI":"10.1038\/icb.2008.17"},{"key":"e_1_2_19_127_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-immunol-083122-044829"},{"key":"e_1_2_19_128_1","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(200106)44:6<1313::AID-ART223>3.0.CO;2-S"},{"key":"e_1_2_19_129_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1610528"},{"key":"e_1_2_19_130_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(04)00079-2"},{"key":"e_1_2_19_131_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.35074"},{"key":"e_1_2_19_132_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1002176"},{"key":"e_1_2_19_133_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20191336"},{"key":"e_1_2_19_134_1","doi-asserted-by":"publisher","DOI":"10.1093\/jimmun\/vkag002"},{"key":"e_1_2_19_135_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20150537"},{"key":"e_1_2_19_136_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2018.03.012"},{"key":"e_1_2_19_137_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.202149244"},{"key":"e_1_2_19_138_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2015.04.007"},{"key":"e_1_2_19_139_1","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.172219"},{"key":"e_1_2_19_140_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20151978"},{"key":"e_1_2_19_141_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2665-9913(22)00332-0"},{"key":"e_1_2_19_142_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng1601"},{"key":"e_1_2_19_143_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humimm.2010.02.002"},{"key":"e_1_2_19_144_1","doi-asserted-by":"publisher","DOI":"10.3390\/medicina57080827"},{"key":"e_1_2_19_145_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2008-02-141937"},{"key":"e_1_2_19_146_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2011.01.048"},{"key":"e_1_2_19_147_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2010.08.017"},{"key":"e_1_2_19_148_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-0039.2001.580403.x"},{"key":"e_1_2_19_149_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2004.10.048"},{"key":"e_1_2_19_150_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clim.2007.04.012"},{"key":"e_1_2_19_151_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI69854"},{"key":"e_1_2_19_152_1","doi-asserted-by":"publisher","DOI":"10.70962\/jhi.20250016"},{"key":"e_1_2_19_153_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-03620-2"},{"key":"e_1_2_19_154_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2001180"},{"key":"e_1_2_19_155_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(10)61354-2"},{"key":"e_1_2_19_156_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2013.12.002"},{"key":"e_1_2_19_157_1","doi-asserted-by":"publisher","DOI":"10.7326\/M21-2078"},{"key":"e_1_2_19_158_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41588-023-01422-x"},{"key":"e_1_2_19_159_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000003099"},{"key":"e_1_2_19_160_1","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.0000001089"},{"key":"e_1_2_19_161_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2305635"},{"key":"e_1_2_19_162_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2024.03.012"},{"key":"e_1_2_19_163_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.40360"},{"key":"e_1_2_19_164_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keab115"},{"key":"e_1_2_19_165_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2514415"},{"key":"e_1_2_19_166_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard-2023-224854"},{"key":"e_1_2_19_167_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(21)02251-0"},{"key":"e_1_2_19_168_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ard.2025.11.015"},{"key":"e_1_2_19_169_1","doi-asserted-by":"publisher","DOI":"10.2147\/BTT.S539066"},{"key":"e_1_2_19_170_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2203478"},{"key":"e_1_2_19_171_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ard.2026.1005.1021"},{"key":"e_1_2_19_172_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2024850"},{"key":"e_1_2_19_173_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(21)00933-8"},{"key":"e_1_2_19_174_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-025-03937-8"},{"key":"e_1_2_19_175_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-022-01278-3"},{"key":"e_1_2_19_176_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard-2024-225785"},{"key":"e_1_2_19_177_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eclinm.2025.103621"}],"container-title":["Immunological Reviews"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/imr.70170","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/imr.70170","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/imr.70170","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T08:09:50Z","timestamp":1790150990000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/imr.70170"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":176,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["10.1111\/imr.70170"],"URL":"https:\/\/doi.org\/10.1111\/imr.70170","archive":["Portico"],"relation":{},"ISSN":["0105-2896","1600-065X"],"issn-type":[{"value":"0105-2896","type":"print"},{"value":"1600-065X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"2026-08-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-21","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-17","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70170"}}