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High\u2010throughput T\u2010cell receptor (TCR) repertoire sequencing has transformed our ability to characterize these responses, providing unprecedented insights into clonal dynamics, antigen\u2010driven selection, and immune history. In this review, we summarize the major alterations of TCR repertoires reported across autoimmune diseases, including changes in diversity, clonal expansion, repertoire architecture, and tissue distribution. We discuss the principal biological and technical challenges that currently limit repertoire interpretation, with particular emphasis on the concept that bulk repertoires represent composite mixtures of biologically distinct T\u2010cell populations. Finally, we highlight emerging approaches integrating single\u2010cell profiling, computational modeling, and antigen\u2010specificity inference that are reshaping the field. 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