{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T17:49:27Z","timestamp":1791481767951,"version":"4.3.4"},"reference-count":181,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T00:00:00Z","timestamp":1788825600000},"content-version":"vor","delay-in-days":7,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100006984","name":"Irma T. 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Repeated exposures through infection and vaccination coupled with continuous antigenic drift generate complex immune histories and reveal which viral surfaces evolve under antibody pressure. Structural studies have transformed the field by showing how antibody repertoires solve epitope\u2010specific recognition problems. Some epitopes, such as the HA central stem, recruit highly stereotyped genetic and structural solutions. Others, such as the receptor\u2010binding site, can be approached by genetically diverse antibodies that converge on common structural solutions of receptor mimicry. Additional epitopes, including the lateral patch, anchor, head interface, and head\u2010stem junction, reveal intermediate patterns of repertoire constraint. Together, these examples show that what antibody repertoires \u201csee\u201d is determined by the interplay between viral glycoprotein structure, B cell precursor availability, somatic evolution, and population\u2010level immunoglobulin diversity.<\/jats:p>","DOI":"10.1111\/imr.70176","type":"journal-article","created":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T04:57:36Z","timestamp":1788929856000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["What Antibody Repertoires See: Structural and Immunogenetic Insights Into Influenza A Virus Hemagglutinin Recognition"],"prefix":"10.1111","volume":"342","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-5355-1735","authenticated-orcid":false,"given":"Bruno","family":"Bonnettaz","sequence":"first","affiliation":[{"name":"Department of Microbiology Icahn School of Medicine at Mount Sinai  New York New York 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