{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T07:01:18Z","timestamp":1790665278858,"version":"4.1.0"},"reference-count":137,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T00:00:00Z","timestamp":1790553600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T00:00:00Z","timestamp":1790553600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100002915","name":"Fondation pour la Recherche M\u00e9dicale","doi-asserted-by":"publisher","award":["MND202310017967"],"award-info":[{"award-number":["MND202310017967"]}],"id":[{"id":"10.13039\/501100002915","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001961","name":"AXA Research Fund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001961","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Immunological Reviews"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Interleukin (IL)\u201010\u2010producing B cells represent an archetype for the regulatory functions of B cells. Here, we review the cell\u2010surface receptors and transcriptional regulators that control IL\u201010 expression in B cells and enable their regulatory function in\u00a0vivo. To integrate available data, we propose a three\u2010layer competence\u2013execution\u2013stabilization (CES) framework for IL\u201010\u2010mediated B cell regulation. We propose that B cell receptor signaling during B cell development and at homeostasis contributes to establishing high IL\u201010 competence in selected B cell subsets at steady state. Execution of IL\u201010 expression and regulatory function then requires the integration of canonical B cell activation pathways with environmental signals and involves transcriptional programs that are largely intertwined with those controlling plasma cell differentiation. Notably, chemically induced IL\u201010\u2010producing B cells progressively differentiate into IL\u201010\u2010producing plasma cells and acquire homogeneous and stable IL\u201010 expression. Together with LAG\u20103\n                    <jats:sup>+<\/jats:sup>\n                    CD138\n                    <jats:sup>hi<\/jats:sup>\n                    plasma cells, these cells represent the only B cell populations described so far in which IL\u201010 expression approaches population\u2010wide penetrance. We therefore propose that plasma cell differentiation may constitute an attractor state for stabilizing IL\u201010\u2010producing regulatory programs. The CES framework provides a conceptual basis for investigating the diversity and regulatory functions of IL\u201010\u2010expressing B cell states in\u00a0vivo.\n                  <\/jats:p>","DOI":"10.1111\/imr.70180","type":"journal-article","created":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T06:23:11Z","timestamp":1790662991000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Building an Interleukin\u201010\u2010Producing Identity: How B Cells Acquire Interleukin\u201010 Competence and How Plasma Cell Differentiation Consolidates This Program"],"prefix":"10.1111","volume":"343","author":[{"given":"Bui Thi","family":"Cuc","sequence":"first","affiliation":[{"name":"INSERM U1151, CNRS UMR8253, Institut Necker Enfants Malades Universit\u00e9 Paris Cit\u00e9  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanli","family":"Tong","sequence":"additional","affiliation":[{"name":"INSERM U1151, CNRS UMR8253, Institut Necker Enfants Malades Universit\u00e9 Paris Cit\u00e9  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiguo","family":"Wu","sequence":"additional","affiliation":[{"name":"INSERM U1151, CNRS UMR8253, Institut Necker Enfants Malades Universit\u00e9 Paris Cit\u00e9  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Alvarez\u2010Simon","sequence":"additional","affiliation":[{"name":"INSERM U1151, CNRS UMR8253, Institut Necker Enfants Malades Universit\u00e9 Paris Cit\u00e9  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7730-9917","authenticated-orcid":false,"given":"Simon","family":"Fillatreau","sequence":"additional","affiliation":[{"name":"INSERM U1151, CNRS UMR8253, Institut Necker Enfants Malades Universit\u00e9 Paris Cit\u00e9  Paris France"},{"name":"Facult\u00e9 de M\u00e9decine Universit\u00e9 Paris Cit\u00e9  Paris France"},{"name":"AP\u2010HP, H\u00f4pital Necker\u2010Enfants Malades  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,28]]},"reference":[{"issue":"10","key":"e_1_2_11_2_1","doi-asserted-by":"crossref","first-page":"944","DOI":"10.1038\/ni833","article-title":"B Cells Regulate Autoimmunity by Provision of IL\u201010","volume":"3","author":"Fillatreau S.","year":"2002","journal-title":"Nature Immunology"},{"issue":"7492","key":"e_1_2_11_3_1","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1038\/nature12979","article-title":"IL\u201035\u2010Producing B Cells Are Critical Regulators of Immunity During Autoimmune and Infectious Diseases","volume":"507","author":"Shen P.","year":"2014","journal-title":"Nature"},{"issue":"1","key":"e_1_2_11_4_1","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.immuni.2018.06.007","article-title":"LAG\u20103 Inhibitory Receptor Expression Identifies Immunosuppressive Natural Regulatory Plasma Cells","volume":"49","author":"Lino A. 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