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The impact of antenatal exposures to maternal treatments, in the context of genetic vulnerability of the fetus, on sensorimotor functioning in early infancy remains unexplored. Statistical features of head movements obtained from resting\u2010state sleep fMRI scans are examined in 1\u2010 to 2\u2010month\u2010old infants, both those at high risk (HR) for autism spectrum disorder (ASD) due to a biological sibling with ASD and at low risk (LR) (<jats:italic>N<\/jats:italic>\u00a0=\u00a056). In utero exposures include maternal prescription medications (psychotropic Rx: <jats:italic>N<\/jats:italic>\u00a0=\u00a03<jats:sub>HR<\/jats:sub>; <jats:italic>N<\/jats:italic>\u00a0=\u00a05<jats:sub>LR<\/jats:sub> vs. non\u2010psychotropic Rx: <jats:italic>N<\/jats:italic>\u00a0=\u00a011<jats:sub>HR<\/jats:sub>; <jats:italic>N<\/jats:italic>\u00a0=\u00a09<jats:sub>LR<\/jats:sub> vs. none: <jats:italic>N<\/jats:italic>\u00a0=\u00a011<jats:sub>HR<\/jats:sub>; <jats:italic>N<\/jats:italic>\u00a0=\u00a016<jats:sub>LR<\/jats:sub>), psychiatric diagnoses (two or more Dx<jats:sub>2<\/jats:sub>: <jats:italic>N<\/jats:italic>\u00a0=\u00a05<jats:sub>HR<\/jats:sub>; <jats:italic>N<\/jats:italic>\u00a0=\u00a01<jats:sub>LR<\/jats:sub>; one Dx<jats:sub>1<\/jats:sub>: <jats:italic>N<\/jats:italic>\u00a0=\u00a04<jats:sub>HR<\/jats:sub>; <jats:italic>N<\/jats:italic>\u00a0=\u00a05<jats:sub>LR<\/jats:sub>; no Dx: <jats:italic>N<\/jats:italic>\u00a0=\u00a012<jats:sub>HR<\/jats:sub>; <jats:italic>N<\/jats:italic>\u00a0=\u00a019<jats:sub>LR<\/jats:sub>), infections requiring antibiotics (infection: <jats:italic>N<\/jats:italic>\u00a0=\u00a05<jats:sub>HR<\/jats:sub>; <jats:italic>N<\/jats:italic>\u00a0=\u00a08<jats:sub>LR<\/jats:sub>; no infection: <jats:italic>N<\/jats:italic>\u00a0=\u00a020<jats:sub>HR<\/jats:sub>; <jats:italic>N<\/jats:italic>\u00a0=\u00a022<jats:sub>LR<\/jats:sub>), or high fever (fever: <jats:italic>N<\/jats:italic>\u00a0=\u00a02<jats:sub>HR<\/jats:sub>; <jats:italic>N<\/jats:italic>\u00a0=\u00a02<jats:sub>LR<\/jats:sub>; no fever: <jats:italic>N<\/jats:italic>\u00a0=\u00a023<jats:sub>HR<\/jats:sub>; <jats:italic>N<\/jats:italic>\u00a0=\u00a027<jats:sub>LR<\/jats:sub>). Movements with significantly higher variability are detected in infants exposed to psychotropics (e.g., opioid analgesics) and those whose mothers had fever, and this effect is significantly worse for infants at HR for ASD. Movements are significantly less variable in HR infants with non\u2010psychotropic exposures (e.g., antibiotics). Heightened number of psychiatric or mental health conditions is associated with noisier movements in both risk groups. Genetic vulnerability due to in utero exposure to maternal treatments is an important future approach to be advanced in the field of early mind and brain development.<\/jats:p>","DOI":"10.1111\/infa.12398","type":"journal-article","created":{"date-parts":[[2021,4,21]],"date-time":"2021-04-21T12:39:21Z","timestamp":1619008761000},"page":"514-531","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Genetic vulnerability of exposures to antenatal maternal treatments in 1\u2013 to 2\u2010month\u2010old infants"],"prefix":"10.1111","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0104-019X","authenticated-orcid":false,"given":"Kristina","family":"Denisova","sequence":"first","affiliation":[{"name":"Sackler Institute for Developmental Psychobiology Columbia University College of Physicians and Surgeons  New York NY USA"},{"name":"Department of Psychiatry Columbia University College of Physicians and Surgeons  New York NY USA"},{"name":"Division of Developmental Neuroscience New York State Psychiatric Institute  New York NY USA"},{"name":"Biobehavioral Sciences Department Teachers College Columbia University  New York NY USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,4,20]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tics.2018.05.010"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1009838108"},{"key":"e_1_2_7_4_1","first-page":"136","volume-title":"Neonatal and pediatric pharmacology: Therapeutic principles in practice","author":"Boskovic R.","year":"2005"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2010.12.039"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0064654"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.infbeh.2019.03.008"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bandl.2019.04.002"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2018.07.023"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-09028-0"},{"issue":"2","key":"e_1_2_7_11_1","doi-asserted-by":"crossref","first-page":"e00596","DOI":"10.1002\/brb3.596","article-title":"Cortical interactions during the resolution of information processing demands in autism spectrum disorders","volume":"7","author":"Denisova K.","year":"2016","journal-title":"Brain and Behavior"},{"key":"e_1_2_7_12_1","first-page":"338","article-title":"Periodic phenomena in the sleep of children","volume":"2","author":"Denisova M. 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