{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T19:17:06Z","timestamp":1790709426975,"version":"4.1.0"},"reference-count":185,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,3,28]],"date-time":"2026-03-28T00:00:00Z","timestamp":1774656000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,3,28]],"date-time":"2026-03-28T00:00:00Z","timestamp":1774656000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Mental Health Nurs"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>The game changers in mental health and substance use disorder treatment have been shaped by historical sea changes marked by transformative advancements that have significantly enhanced patient care. Breakthroughs in psychotherapy, psychosurgery and psychopharmacology have each contributed to reshaping clinical practices, especially the revolutionary discovery of psychotropics. More recently, the rapid development of artificial intelligence has begun to address long\u2010standing barriers in access to care for individuals experiencing mental health and substance use disorders. Transitioning from past eras characterised by institutionalisation and inhumane treatment, the field of mental health and substance use has embraced a more holistic, patient\u2010centred and community\u2010based approach. Landmark legislation and progressive policy frameworks have played a vital role in safeguarding the rights and dignity of individuals living with mental health and substance use disorders. Patient engagement, the cornerstone of effective treatment, continues to evolve alongside the expansion of therapeutic options, from patients having no autonomy over decisions to encouraging clients to make informed decisions about their care. Within this dynamic landscape, nurses serve as essential gatekeepers of the healthcare system, providing critical functions such as clinical assessment, medication administration, patient education, counselling and ongoing monitoring to mitigate adverse treatment outcomes and support recovery, while establishing a therapeutic relationship in all aspects of care. This historical discussion paper explores and summarises the key game changer events by highlighting the treatment and engagement of persons living with mental health and substance abuse disorders of the past in timeline periods. Predictions for the future are also projected to encourage reflections of the past and thought\u2010provoking acumens for the future.<\/jats:p>","DOI":"10.1111\/inm.70251","type":"journal-article","created":{"date-parts":[[2026,3,28]],"date-time":"2026-03-28T07:48:43Z","timestamp":1774684123000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Game Changers in the Treatment of and Engagement With Persons Living With Mental Health and Substance Use Disorders: The Role of the Nurse"],"prefix":"10.1111","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2338-2246","authenticated-orcid":false,"given":"Arlene","family":"Kent\u2010Wilkinson","sequence":"first","affiliation":[{"name":"College of Nursing, University of Saskatchewan  Saskatoon Saskatchewan Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sudor","family":"Ogunwemimo","sequence":"additional","affiliation":[{"name":"College of Nursing, University of Saskatchewan  Saskatoon Saskatchewan Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eileen","family":"Zaba","sequence":"additional","affiliation":[{"name":"Saskatchewan Polytechnic  Saskatoon Saskatchewan Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,3,28]]},"reference":[{"key":"e_1_2_19_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/bdi.13019"},{"key":"e_1_2_19_3_1","unstructured":"Aiken L.2024.\u201cComment: The New Dangers of Firefighting.\u201dFirefighting in Canada.https:\/\/www.firefightingincanada.com\/comment\u2010the\u2010new\u2010dangers\u2010of\u2010fire\u2010fighting\/."},{"key":"e_1_2_19_4_1","unstructured":"Alberta Health Services.2025.\u201cHarm Reduction.\u201dhttps:\/\/albertahealthservices.ca\/dsa\/page15432.aspx."},{"key":"e_1_2_19_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/qje\/qjab043"},{"key":"e_1_2_19_6_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.books.9780890425787"},{"key":"e_1_2_19_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600\u20100447.2005.00699.x"},{"key":"e_1_2_19_8_1","volume-title":"Reframing Diversity and Inclusive Leadership: Race, Gender, and Institutional Change","author":"Asumah S. N.","year":"2024"},{"key":"e_1_2_19_9_1","doi-asserted-by":"publisher","DOI":"10.3390\/healthcare11131954"},{"key":"e_1_2_19_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.NURSE.0000923636.81132.2a"},{"key":"e_1_2_19_11_1","unstructured":"Bilsland L.2024.\u201cA New Approach for Treating Schizophrenia.\u201dWelcome.org.https:\/\/wellcome.org\/news\/new\u2010treatment\u2010for\u2010schizophrenia\u2010Cobenfy."},{"key":"e_1_2_19_12_1","unstructured":"Bjugstad K. B.2024.\u201cIs Cobenfy the First Fourth\u2010Generation Antipsychotic?\u201dMed Central.https:\/\/www.medcentral.com\/behavioral\u2010mental\/schizophrenia\/is\u2010cobenfy\u2010the\u2010first\u2010fourth\u2010generation\u2010antipsychotic."},{"key":"e_1_2_19_13_1","first-page":"2","volume-title":"Psychiatric & Mental Health Nursing for Canadian Practice (5th ed., Chapter\u00a01)","author":"Boschma G.","year":"2023"},{"key":"e_1_2_19_14_1","unstructured":"British Broadcasting Company.2019.\u201cUruguay: The World's Marijuana Pioneer (by Simon Maybin BBC News).\u201dhttps:\/\/www.bbc.com\/news\/business\u201047785648."},{"key":"e_1_2_19_15_1","unstructured":"Brousseau S.2024.\u201cOnce and for All It's Time to Recognize That All Nurses Are the Solution to Better Primary Care Access.\u201dThe Canadian Nurse.https:\/\/www.canadian\u2010nurse.com\/blogs\/cn\u2010content\/2024\/05\/06\/nurses\u2010solution\u2010to\u2010better\u2010primary\u2010care\u2010access."},{"key":"e_1_2_19_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.avb.2019.01.001"},{"key":"e_1_2_19_17_1","unstructured":"Canadian Association of Schools of Nursing.2025.\u201cCultural Humility and Cultural Safety Standards for Nursing Education.\u201dhttps:\/\/www.casn.ca\/wp\u2010content\/uploads\/2025\/02\/CASN_Cultural_Humility_Safety_Standards_2024_EN.pd."},{"key":"e_1_2_19_18_1","unstructured":"Canadian Broadcasting Corporation News.2016.\u201cThe Year of the Fentanyl Crisis: How We Got Here.\u201dhttps:\/\/www.cbc.ca\/news\/health\/fentanyl\u2010carfentanil\u2010opioid\u2010crisis\u2010spreading\u2010across\u2010canada\u20101.3909986."},{"key":"e_1_2_19_19_1","unstructured":"Canadian Centre on Substance Use and Addiction.2020.\u201cImpacts of the COVID\u201019 Pandemic on Substance Use Treatment Capacity in Canada.\u201dhttps:\/\/www.ccsa.ca\/sites\/default\/files\/2020\u201012\/CCSA\u2010COVID\u201019\u2010Impacts\u2010Pandemic\u2010Substance\u2010Use\u2010Treatment\u2010Capacity\u2010Canada\u20102020\u2010en.pdf."},{"key":"e_1_2_19_20_1","unstructured":"Canadian Council on Rehabilitation and Work.2025.\u201cDEI: What It Means and Why It Matters.\u201dhttps:\/\/ccrw.org\/the\u2010importance\u2010of\u2010dei\u2010idea\/."},{"key":"e_1_2_19_21_1","unstructured":"Canadian Federation of Mental Health Nurses.2023.\u201cCanadian Standards of Practice for Psychiatric\u2010Mental Health Nursing (5th Ed.).\u201dhttps:\/\/www.cfmhn.ca\/standards."},{"key":"e_1_2_19_22_1","unstructured":"Canadian Federation of Nursing Unions.2022.\u201cCanada's Nursing Shortage at a Glance A Media Reference Guide.\u201dhttps:\/\/nursesunions.ca\/wp\u2010content\/uploads\/2022\/07\/nurses_shortage_media_ref_guide_comp.pdf."},{"key":"e_1_2_19_23_1","unstructured":"Canadian Mental Health Association.2024.\u201cThe State of Mental Health in Canada.\u201dhttps:\/\/cmha.ca\/wp\u2010content\/uploads\/2024\/11\/CMHA\u2010State\u2010of\u2010Mental\u2010Health\u20102024\u2010report.pdf."},{"key":"e_1_2_19_24_1","unstructured":"Canadian Mental Health Association.2025.\u201cStigma Remains a Barrier to Mental Health Care With 60% of People Not Seeking Help for Fear of Being Labelled.\u201dhttps:\/\/cmha.ca\/news\/stigma\u2010remains\u2010a\u2010barrier\u2010to\u2010mental\u2010health\u2010care\u2010with\u201060\u2010of\u2010people\u2010not\u2010seeking\u2010help\u2010for\u2010fear\u2010of\u2010being\u2010labelled."},{"key":"e_1_2_19_25_1","unstructured":"Canadian Nurses Association.2021.\u201cRegulated Nursing in Canada: The Landscape in 2021 (by Joan Almost Scholar in Residence).\u201dhttps:\/\/www.cna\u2010aiic.ca\/en\/nursing\/regulated\u2010nursing\u2010in\u2010canada."},{"key":"e_1_2_19_26_1","unstructured":"Canadian Nurses Association.2025.\u201cCode of Ethics for Nurses.\u201dhttps:\/\/www.cna\u2010aiic.ca\/en\/nursing\/regulated\u2010nursing\u2010in\u2010canada\/nursing\u2010ethics\/2025\u2010coe."},{"key":"e_1_2_19_27_1","unstructured":"Canadian Red Cross.2021.\u201cThe Shadow Pandemic: Increased Sexual\u2010 and Gender\u2010Based Violence During COVID\u201019.\u201dBy Global Administrator.https:\/\/www.redcross.ca\/blog\/2021\/12\/the\u2010shadow\u2010pandemic\u2010increased\u2010sexual\u2010and\u2010gender\u2010based\u2010violence\u2010during\u2010covid\u201019."},{"key":"e_1_2_19_28_1","doi-asserted-by":"publisher","DOI":"10.3171\/2017.6.FOCUS17257"},{"key":"e_1_2_19_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/bdi.13031"},{"key":"e_1_2_19_30_1","unstructured":"Centre for Addiction and Mental Health.2026a.\u201cConcurrent Addiction and Mental Health Disorders: An Information Guide.\u201dhttps:\/\/www.camh.ca\/\u2010\/media\/health\u2010info\u2010files\/publications\/concurrent\u2010disorders\u2010information\u2010guide\u2010pdf.pdf."},{"key":"e_1_2_19_31_1","unstructured":"Centre for Addiction and Mental Health.2026b.\u201cDialectical Behaviour Therapy (DBT).\u201dhttps:\/\/www.camh.ca\/en\/health\u2010info\/mental\u2010illness\u2010and\u2010addiction\u2010index\/dialectical\u2010behaviour\u2010therapy."},{"key":"e_1_2_19_32_1","unstructured":"Centre for Health Care Strategies.2025.\u201cWhat is Trauma Informed Care? Trauma\u2010Informed Care Implementation Resource Centre.\u201dhttps:\/\/www.traumainformedcare.chcs.org\/what\u2010%20is\u2010trauma\u2010informed\u2010care\/."},{"key":"e_1_2_19_33_1","unstructured":"Circle of Care.2025.\u201cRecognizing the Evolving and Diverse Role of Nurses.\u201dCircle of Care Sinai Health.https:\/\/circleofcare.com\/recognizing\u2010the\u2010evolving\u2010and\u2010diverse\u2010role\u2010of\u2010nurses\/."},{"key":"e_1_2_19_34_1","unstructured":"College of Physicians and Surgeons of Alberta.2025.\u201cOpioid Agonist Reatment Program.\u201dhttps:\/\/cpsa.ca\/physicians\/competence\/physician\u2010prescribing\u2010practices\/opioid\u2010agonist\u2010treatment\u2010program\/."},{"key":"e_1_2_19_35_1","unstructured":"College of Registered Nurses Saskatchewan.2021.\u201cMedication Management Guideline.\u201dhttps:\/\/www.srna.org\/wp\u2010content\/uploads\/2021\/09\/Medication\u2010Management\u2010Guideline\u2010SRNA\u20102021.pdf."},{"key":"e_1_2_19_36_1","unstructured":"Correctional Service Canada.2024.\u201cPrison Needle Exchange Program (PNEP).\u201dhttps:\/\/www.canada.ca\/en\/correctional\u2010service\/programs\/offenders\/health\u2010services\/prison\u2010needle\u2010exchange\u2010program.html."},{"key":"e_1_2_19_37_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10597\u2010007\u20109084\u20109"},{"key":"e_1_2_19_38_1","doi-asserted-by":"publisher","DOI":"10.1353\/cwh.1978.0039"},{"key":"e_1_2_19_39_1","unstructured":"Craig S.2019.Timeline of the Opioid Crisis in CanadaThe Link Newspaper.https:\/\/thelinknewspaper.ca\/article\/timeline\u2010of\u2010the\u2010opioid\u2010crisis\u2010in\u2010Canada\/."},{"key":"e_1_2_19_40_1","unstructured":"Dattani S.2024.\u201cAntipsychotic Medications: A Timeline of Innovations and Remaining Challenges.\u201dOurWorldinData.org.https:\/\/ourworldindata.org\/antipsychotic\u2010medications\u2010timeline."},{"key":"e_1_2_19_41_1","doi-asserted-by":"publisher","DOI":"10.2174\/1570159X2111230804161745"},{"key":"e_1_2_19_42_1","doi-asserted-by":"publisher","DOI":"10.1093\/schizbullopen\/sgac053"},{"key":"e_1_2_19_43_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1369-7625.2005.00352.x"},{"key":"e_1_2_19_44_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12888\u2010025\u201006483\u20102"},{"key":"e_1_2_19_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2020.06.017"},{"issue":"3","key":"e_1_2_19_46_1","first-page":"46","article-title":"Treatment for the \u2018untreatable\u2019: Despite the Difficult\u2010To\u2010Treat Reputation of Personality Disorders, Clinical Trials of Treatments Show Promise","volume":"35","author":"Dingfelder S. F.","year":"2004","journal-title":"American Psychology Association"},{"key":"e_1_2_19_47_1","unstructured":"Dizizdayana M.2025.\u201cOverview of Firefighter Nursing and Its Importance.\u201dQuizlet.https:\/\/quizlet.com\/study\u2010guides\/overview\u2010of\u2010firefighter\u2010nursing\u2010and\u2010its\u2010importance\u2010f43d5178\u201075e3\u20104fc6\u2010a7e8\u201070f8be3daf43."},{"key":"e_1_2_19_48_1","volume-title":"An Introduction to Indigenous Health and Healthcare in Canada: Bridging Health and Healing","author":"Douglas V.","year":"2022"},{"key":"e_1_2_19_49_1","unstructured":"Drugs.com.2023.\u201cAbilify Asimtufil (Airiprazole) FDA Approval History.\u201dhttps:\/\/www.drugs.com."},{"key":"e_1_2_19_50_1","unstructured":"Drugs.com.2025.\u201cBenzodiazepine Overdose.\u201dhttps:\/\/www.drugs.com\/cg\/benzodiazepine\u2010overdose.html."},{"key":"e_1_2_19_51_1","doi-asserted-by":"publisher","DOI":"10.3138\/9781442699335"},{"key":"e_1_2_19_52_1","unstructured":"Dyck E.2019.\u201cPsychedelic Research in 1950s Saskatchewan.\u201dThe Canadian Encyclopedia.https:\/\/www.thecanadianencyclopedia.ca\/en\/article\/psychedelic\u2010research\u2010in\u20101950s\u2010saskatchewan."},{"key":"e_1_2_19_53_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471\u20102458\u201010\u201033"},{"key":"e_1_2_19_54_1","unstructured":"Fabian R.2017.\u201cThe History of Inhumane Mental Health Treatments.\u201dTalkspace.https:\/\/www.talkspace.com\/blog\/history\u2010inhumane\u2010mental\u2010health\u2010treatments\/#:~:text=Drugs%20had%20been%20used%20in decreased%20to%20just%20over%2070%2C000."},{"key":"e_1_2_19_55_1","doi-asserted-by":"publisher","DOI":"10.6004\/jadpro.2025.16.4.1"},{"key":"e_1_2_19_56_1","doi-asserted-by":"publisher","DOI":"10.1503\/cmaj.230128"},{"key":"e_1_2_19_57_1","unstructured":"Fifield J.2026.\u201cTrump Administration Proposes Defunding Federal Narcan Distribution Program.\u201dAmerican Addiction Centres.https:\/\/americanaddictioncenters.org\/blog\/trump\u2010administration\u2010possibly\u2010defunding\u2010narcan\u2010program."},{"key":"e_1_2_19_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lana.2023.100437"},{"key":"e_1_2_19_59_1","doi-asserted-by":"publisher","DOI":"10.1177\/1461444820931024"},{"key":"e_1_2_19_60_1","unstructured":"Friedman H.2024.\u201cBeyond Willpower: The Disease Model of Addiction.\u201dhttps:\/\/recovery.com\/resources\/disease\u2010model\u2010of\u2010addiction\/#:~:text=How%20the%20Disease%20Model%20Evolved%20in%20Addiction the%20late%2019th%20and%20early%2020th%20centuries."},{"key":"e_1_2_19_61_1","doi-asserted-by":"publisher","DOI":"10.12659\/MSM.944605"},{"key":"e_1_2_19_62_1","unstructured":"Government of Alberta.2020.\u201cAlberta COVID\u201019 Opioid Response Surveillance Report.\u201dhttps:\/\/open.alberta.ca\/dataset\/f4b74c38\u201088cb\u201041ed\u2010aa6f\u201032db93c7c391\/resource\/e8c44bab\u2010900a\u20104af4\u2010905a\u20108b3ef84ebe5f\/download\/health\u2010alberta\u2010covid\u201019\u2010opioid\u2010response\u2010surveillance\u2010report\u20102020\u2010q2.pdf."},{"key":"e_1_2_19_63_1","unstructured":"Government of Alberta.2023.\u201cProtection of Children Abusing Drugs Act.\u201dhttps:\/\/open.alberta.ca\/publications\/p27p5."},{"key":"e_1_2_19_64_1","unstructured":"Government of Alberta.2025.\u201cProviding Life\u2010Saving Treatment for Substance Abuse and Addiction.\u201dhttps:\/\/www.alberta.ca\/providing\u2010life\u2010saving\u2010treatment\u2010for\u2010substance\u2010abuse\u2010and\u2010addiction#:~:text=Status:%20The%20Compassionate%20Intervention%20Act live%20a%20purpose%2Dfilled%20life."},{"key":"e_1_2_19_65_1","unstructured":"Government of Canada.1982.\u201cThe Canadian Charter of Rights and Freedoms.\u201dhttps:\/\/www.justice.gc.ca\/eng\/csj\u2010sjc\/rfc\u2010dlc\/ccrf\u2010ccdl\/index.html."},{"key":"e_1_2_19_66_1","unstructured":"Government of Canada.2002.\u201cRomanow Report. Building on Values: The Future of Health Care in Canada.\u201dCommission of the Future of Health Care in Canada.https:\/\/publications.gc.ca\/collections\/Collection\/CP32\u201085\u20102002E.pdf."},{"key":"e_1_2_19_67_1","unstructured":"Government of Canada.2006.\u201cOut of the Shadows at Last: Transforming Mental Health Mentalillness and Addiction Services in Canada (Chaired by Michael J. L. Kirby and Wilbert Joseph Keon).\u201dFinal Report on Mental Health Mental Illness and Addiction. Standing Senate Committee on Social Affairs Science and Technology.https:\/\/publications.gc.ca\/site\/eng\/9.571040\/publication.html."},{"key":"e_1_2_19_68_1","unstructured":"Government of Canada.2018.\u201cCannabis Act 2018.\u201dDepartment of Justice Canada.https:\/\/laws\u2010lois.justice.gc.ca\/eng\/acts\/c\u201024.5\/fulltext.html."},{"key":"e_1_2_19_69_1","unstructured":"Government of Canada.2024a.\u201cHow Naloxone is Helping to Address Canada's Overdose Crisis.\u201dhttps:\/\/www.canada.ca\/en\/health\u2010canada\/services\/opioids\/naloxone.html#5."},{"key":"e_1_2_19_70_1","unstructured":"Government of Canada.2024b.\u201cMedical Assistance in Dying: Legislation in Canada.\u201dhttps:\/\/www.canada.ca\/en\/health\u2010canada\/services\/health\u2010services\u2010benefits\/medical\u2010assistance\u2010dying\/legislation\u2010canada.html."},{"key":"e_1_2_19_71_1","unstructured":"Government of Canada.2024a.\u201cPersonal Possession of Small Amounts of Certain Illegal Drugs in British Columbia.\u201dHealth Canada.https:\/\/www.canada.ca\/en\/health\u2010canada\/news\/2024\/05\/personal\u2010possession\u2010of\u2010small\u2010amounts\u2010of\u2010certain\u2010illegal\u2010drugs\u2010in\u2010british\u2010columbia.html."},{"key":"e_1_2_19_72_1","unstructured":"Government of Saskatchewan.2015.\u201cGuide to the Mental Health Services Act.\u201dhttps:\/\/www.ehealthsask.ca\/services\/resources\/Resources\/GuidetoTheMentalHealthServicesAct\u2010Nov\u20102015.pdf."},{"key":"e_1_2_19_73_1","unstructured":"Government of Saskatchewan.2021.\u201cMental Health Services Act of Saskatchewan. Chapter M\u201013.1. 1984 Amended 1986 Amended 2015.\u201dPublications Centre.https:\/\/pepsask.ca\/wp\u2010content\/uploads\/2022\/04\/M13\u20101\u20101.pdf."},{"key":"e_1_2_19_74_1","unstructured":"Grantham\u2010Philips W.2025.\u201cTrump Launched Global Tariff Wars in 2025. Here's Are Cap of his Trade Actions This Year.\u201dToronto City News Associated Press.https:\/\/toronto.citynews.ca\/2025\/12\/26\/trump\u2010launched\u2010global\u2010tariff\u2010wars\u2010in\u20102025\u2010heres\u2010a\u2010recap\u2010of\u2010his\u2010trade\u2010actions\u2010this\u2010year\/#:~:text=President%20Donald%20Trump%20launched%20a to%20new%20heights%20in%20April."},{"key":"e_1_2_19_75_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00127\u2010017\u20101341\u20109"},{"key":"e_1_2_19_76_1","volume-title":"Using Trauma Theory to Design Service Systems","author":"Harris M.","year":"2001"},{"key":"e_1_2_19_77_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003\u20104819\u2010157\u20107\u2010201210020\u201000525"},{"key":"e_1_2_19_78_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph18062993"},{"key":"e_1_2_19_79_1","unstructured":"Health Canada.2024.\u201cSubstance Use Disorder.\u201dGovernment of Canada.https:\/\/www.canada.ca\/en\/health\u2010canada\/services\/substance\u2010use\/treatment.html."},{"key":"e_1_2_19_80_1","unstructured":"Health Canada.2025.\u201cCaring for Canadians: Canada's Future Health Workforce\u2014The Canadian Health Workforce Education Training and Distribution Study.\u201dGovernment of Canada.https:\/\/www.canada.ca\/en\/health\u2010canada\/services\/health\u2010care\u2010system\/health\u2010human\u2010resources\/workforce\u2010education\u2010training\u2010distribution\u2010study.html."},{"key":"e_1_2_19_81_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2006.05.032"},{"key":"e_1_2_19_82_1","unstructured":"Indigenous Services Canada.2023.\u201cAn Update on the Socio\u2010Economic Gaps Between Indigenous Peoples and the Non\u2010Indigenous Population in Canada: Highlights From the 2021 Census.\u201dGovernment of Canada.https:\/\/www.sac\u2010isc.gc.ca\/eng\/1690909773300\/1690909797208."},{"issue":"1","key":"e_1_2_19_83_1","first-page":"45","article-title":"Trends in Drug Abuse in the Mid\u20101980s","volume":"60","author":"Jekel J. F.","year":"1987","journal-title":"Yale Journal of Biology & Medicine"},{"key":"e_1_2_19_84_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471\u2010244X\u201012\u2010209"},{"key":"e_1_2_19_85_1","unstructured":"John Hopkins Medicare.2025.\u201cEsketamine for Treatment\u2010Resistant Depression.\u201dhttps:\/\/www.hopkinsmedicine.org\/health\/treatment\u2010tests\u2010and\u2010therapies\/esketamine\u2010for\u2010treatment\u2010resistant\u2010depression."},{"key":"e_1_2_19_86_1","doi-asserted-by":"publisher","DOI":"10.1001\/amajethics.2024.580"},{"key":"e_1_2_19_87_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.20220866"},{"key":"e_1_2_19_88_1","doi-asserted-by":"publisher","DOI":"10.1080\/10550881003684491"},{"key":"e_1_2_19_89_1","unstructured":"Kassam A.2018.\u201cThe Toxic Legacy of Canada's CIA Brainwashing Experiments: \u2018They Strip You of Your Soul\u2019.\u201dThe Guardian.https:\/\/www.theguardian.com\/world\/2018\/may\/03\/montreal\u2010brainwashing\u2010allan\u2010memorial\u2010institute."},{"key":"e_1_2_19_90_1","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD012880.pub2"},{"issue":"11","key":"e_1_2_19_91_1","first-page":"23","article-title":"After the Crime Before the Trial","volume":"89","author":"Kent\u2010Wilkinson A.","year":"1993","journal-title":"Canadian Nurse\/L'infirmiere Canadienne"},{"key":"e_1_2_19_92_1","doi-asserted-by":"publisher","DOI":"10.3109\/01612840903506444"},{"key":"e_1_2_19_93_1","unstructured":"Kent\u2010Wilkinson A.2025.\u201cTimeline: Policies Strategies Laws & Acts.\u201dNURS 486. Forensic Nursing. College of Nursing University of Saskatchewan."},{"key":"e_1_2_19_94_1","unstructured":"Ketamine Assisted Therapy Association of Canada.2022.\u201cA New Hope for the Mental Health Crisis: Ketamine Assisted Therapy.\u201dhttps:\/\/katacanada.org\/."},{"key":"e_1_2_19_95_1","unstructured":"Ketamine Wellness Institute.2023.\u201cWhen Did Ketamine Start Being Used to Treat Depression?\u201dhttps:\/\/ketwell.com\/when\u2010did\u2010ketamine\u2010start\u2010being\u2010used\u2010to\u2010treat\u2010depression\/."},{"key":"e_1_2_19_96_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13033\u2010023\u201000572\u2010z"},{"key":"e_1_2_19_97_1","doi-asserted-by":"publisher","DOI":"10.1111\/acer.15118"},{"key":"e_1_2_19_98_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ps.52.8.1039"},{"key":"e_1_2_19_99_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen\u20102019\u2010029108"},{"key":"e_1_2_19_100_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13011-021-00387-6"},{"key":"e_1_2_19_101_1","doi-asserted-by":"publisher","DOI":"10.46747\/cfp.6707525"},{"key":"e_1_2_19_102_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ps.201800461"},{"key":"e_1_2_19_103_1","doi-asserted-by":"publisher","DOI":"10.2174\/138161209788168001"},{"key":"e_1_2_19_104_1","first-page":"329","article-title":"The History of Barbiturates a Century After Their Clinical Introduction","volume":"4","author":"L\u00f3pez\u2010Mu\u00f1oz F.","year":"2005","journal-title":"Neuropsychiatry Disease and Treatment"},{"key":"e_1_2_19_105_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2155\u20108256(24)00052\u20108"},{"key":"e_1_2_19_106_1","doi-asserted-by":"publisher","DOI":"10.1017\/mdh.2015.68"},{"key":"e_1_2_19_107_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12888\u2010021\u201003372\u20102"},{"key":"e_1_2_19_108_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamapsychiatry.2023.3979"},{"key":"e_1_2_19_109_1","unstructured":"Meissner M.2024.\u201cMNT Investigates: What Are the Antipsychotic Drugs for Schizophrenia?\u201dMedical News Today.https:\/\/www.medicalnewstoday.com\/articles\/schizophrenia\u2010second\u2010generation\u2010antipsychotics#summary."},{"key":"e_1_2_19_110_1","unstructured":"Mental Health Commission of Canada.2012.\u201cChanging Directions Changing Lives: The Mental Health Strategy for Canada.\u201dhttps:\/\/www.mentalhealthcommission.ca\/wp\u2010content\/uploads\/drupal\/MHStrategy_Strategy_ENG.pdf."},{"key":"#cr-split#-e_1_2_19_111_1.1","unstructured":"Mental Health Commission of Canada.2021.\"Mental Health and Substance Use During COVID\u201019: Summary Report [October 13-November 2 2020 (Time 1)"},{"key":"#cr-split#-e_1_2_19_111_1.2","unstructured":"November 19-December 2 2020 (Time 2)].\"Conducted by Leger for the Canadian Centre on Substance Use and Addiction and the Mental Health Commission of Canada.https:\/\/www.mentalhealthcommission.ca\/wp\u2010content\/uploads\/drupal\/2021\u201002\/mhcc_ccsa_covid_leger_poll_eng.pdf."},{"key":"e_1_2_19_112_1","unstructured":"Mental Health Commission of Canada.2022.\u201cAntistigma: Opening Minds.\u201dhttps:\/\/mentalhealthcommission.ca\/what\u2010we\u2010do\/anti\u2010stigma\/."},{"key":"e_1_2_19_113_1","unstructured":"Mental Health Commission of Canada.2023.\u201cAnti\u2010Stigma Research Backgrounder.\u201dhttps:\/\/mentalhealthcommission.ca\/wp\u2010content\/uploads\/2023\/04\/Anti\u2010stigma\u2010Research\u2010Backgrounder.pdf."},{"key":"e_1_2_19_114_1","unstructured":"Mental Health Commission of Canada.2026a.\u201cAnti\u2010Stigma.\u201dhttps:\/\/mentalhealthcommission.ca\/what\u2010we\u2010do\/anti\u2010stigma\/#:~:text=Everyone%20deserves%20to%20live%20a attitude%2C%20behaviour%2C%20and%20performance."},{"key":"e_1_2_19_115_1","unstructured":"Mental Health Commission of Canada.2026a.\u201cOpening Minds.\u201dhttps:\/\/mentalhealthcommission.ca\/opening\u2010minds\/?routetoken=3698167e4806419e0e17de86ea72c500&terminitial=39."},{"key":"e_1_2_19_116_1","unstructured":"Mental Health Commission of Canada.2026b.\u201cPartnership in Action.\u201dhttps:\/\/mentalhealthcommission.ca\/wp\u2010content\/uploads\/2026\/01\/25\u2010120_Report_Layout_E_ACC.pdf."},{"key":"e_1_2_19_117_1","unstructured":"Merriam\u2010Webster Dictionary.2025.\u201cDefinition of Game Changer.\u201dhttps:\/\/www.merriam\u2010webster.com\/dictionary\/game%20changer."},{"key":"e_1_2_19_118_1","doi-asserted-by":"publisher","DOI":"10.1080\/01612840.2024.2427561"},{"key":"e_1_2_19_119_1","doi-asserted-by":"publisher","DOI":"10.2165\/00003495\u2010199652050\u201000001"},{"key":"e_1_2_19_120_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.schres.2022.08.015"},{"key":"e_1_2_19_121_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.focus.20190029"},{"key":"e_1_2_19_122_1","doi-asserted-by":"publisher","DOI":"10.1353\/his.2013.0015"},{"key":"e_1_2_19_123_1","unstructured":"Mueser K. andD.Fulford.2024.\u201cA \u201cGame\u2010Changing\u201d New Drug for Schizophrenia? The Brink: Pioneering Research From Boston University.\u201dhttps:\/\/www.bu.edu\/articles\/2024\/a\u2010game\u2010changing\u2010new\u2010drug\u2010for\u2010schizophrenia\/."},{"key":"e_1_2_19_124_1","doi-asserted-by":"publisher","DOI":"10.1097\/YIC.0000000000000510"},{"key":"e_1_2_19_125_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13030\u2010021\u201000219\u2010w"},{"key":"e_1_2_19_126_1","unstructured":"National Institute of Mental Health.2025.\u201cSubstance Use and Co\u2010Occurring Mental Disorders.\u201dhttps:\/\/www.nimh.nih.gov\/health\/topics\/substance\u2010use\u2010and\u2010mental\u2010health."},{"key":"e_1_2_19_127_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365\u20102850.1997.00070.x"},{"issue":"5","key":"e_1_2_19_128_1","first-page":"37","article-title":"Nurses in Prison","volume":"67","author":"Norens G.","year":"1971","journal-title":"Canadian Nurse"},{"key":"e_1_2_19_129_1","unstructured":"Nurses.com.2025.\u201cHow Forensic Nurses Work With Other Healthcare and Legal Professionals.\u201dhttps:\/\/www.nurse.com\/nursing\u2010resources\/forensic\u2010nurse\u2010resources\/how\u2010forensic\u2010nurses\u2010work\u2010with\u2010other\u2010professionals\/."},{"key":"e_1_2_19_130_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00127\u2010008\u20100476\u20100"},{"key":"e_1_2_19_131_1","unstructured":"Ontario Drug Policy Research Network & Public Health Ontario.2023.\u201cCharacteristics of Substance\u2010Related Toxicity Deaths in Ontario: Stimulant Opioid Benzodiazepine and Alcohol\u2010Related Deaths.\u201dhttps:\/\/odprn.ca\/research\/publications\/characteristics\u2010of\u2010substance\u2010related\u2010toxicity\u2010deaths\u2010in\u2010ontario\/."},{"key":"e_1_2_19_132_1","unstructured":"Ontario Human Rights Commission.2024a.\u201cConsent and Capacity.\u201dhttps:\/\/www3.ohrc.on.ca\/en\/policy\u2010preventing\u2010discrimination\u2010based\u2010mental\u2010health\u2010disabilities\u2010and\u2010addictions\/16\u2010consent\u2010and."},{"key":"e_1_2_19_133_1","unstructured":"Ontario Human Rights Commission.2024b.\u201cDeinstitutionalization. Appendix A: Historical Context. Policy on Preventing Discrimination Based on Mental Health Disabilities and Addictions.\u201dhttps:\/\/www3.ohrc.on.ca\/en\/policy\u2010preventing\u2010discrimination\u2010based\u2010mental\u2010health\u2010disabilities\u2010and\u2010addictions\/appendix#:~:text=Starting%20in%20the%201960s%2C%20under with%20severe%20mental%20health%20disabilities."},{"key":"e_1_2_19_134_1","doi-asserted-by":"publisher","DOI":"10.1192\/S1749367600004525"},{"key":"e_1_2_19_135_1","unstructured":"Oxford Learners Dictionary.2026.\u201cGame Changer.\u201dhttps:\/\/www.oxfordlearnersdictionaries.com\/definition\/english\/game\u2010changer#google_vignette."},{"key":"e_1_2_19_136_1","doi-asserted-by":"publisher","DOI":"10.1177\/10398562221142453"},{"key":"e_1_2_19_137_1","doi-asserted-by":"publisher","DOI":"10.1093\/intqhc\/8.5.491"},{"key":"e_1_2_19_138_1","doi-asserted-by":"publisher","DOI":"10.1002\/symb.574"},{"key":"e_1_2_19_139_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jadr.2025.100886"},{"key":"e_1_2_19_140_1","doi-asserted-by":"publisher","DOI":"10.1111\/jan.16056"},{"key":"e_1_2_19_141_1","unstructured":"Ponic P. C.Varcoe andT.Smutylo.2021.\u201cTrauma\u2010 (and Violence\u2010) Informed Approaches to Supporting Victims of Violence: Policy and Practice Considerations.\u201dVictims of Crime Research Digest No. 9. Department of Justice Government of Canada.https:\/\/www.justice.gc.ca\/eng\/rp\u2010pr\/cj\u2010jp\/victim\/rd9\u2010rr9\/p2.html#:~:text=During%20the%20last%2010%E2%80%9315 responses%20for%20children%20and%20adults."},{"key":"e_1_2_19_142_1","unstructured":"Press Release (PR) Newswire.2019.\u201cJanssen Announces U.S. FDA Approval of Spravato (Esketamine) CIII Nasal Spray for Adults With Treatment\u2010Resistant Depression (TRD) Who Have Cycled Through Multiple Treatments Without Relief: Spravato Uses the First New Mechanism of Action in Decades to Treat Major Depressive Disorder.\u201dPR Newswire.https:\/\/www.prnewswire.com\/news\u2010releases\/janssen\u2010announces\u2010us\u2010fda\u2010approval\u2010of\u2010spravato\u2010esketamine\u2010ciii\u2010nasal\u2010spray\u2010for\u2010adults\u2010with\u2010treatment\u2010resistant\u2010depression\u2010trd\u2010who\u2010have\u2010cycled\u2010through\u2010multiple\u2010treatments\u2010without\u2010relief\u2010300807366.html."},{"key":"e_1_2_19_143_1","doi-asserted-by":"publisher","DOI":"10.12968\/jprp.2021.3.6.235"},{"key":"e_1_2_19_144_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2021.113507"},{"key":"e_1_2_19_145_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00127\u2010019\u201001750\u20106"},{"key":"e_1_2_19_146_1","doi-asserted-by":"publisher","DOI":"10.2147\/PRBM.S371991"},{"key":"e_1_2_19_147_1","unstructured":"Rigby J. andE.Farge.2026.\u201cU.S. Withdraws From the World Health Organization.\u201dhttps:\/\/www.reuters.com\/business\/healthcare\u2010pharmaceuticals\/us\u2010set\u2010quit\u2010world\u2010health\u2010organization\u20102026\u201001\u201022\/."},{"key":"e_1_2_19_148_1","doi-asserted-by":"publisher","DOI":"10.1080\/09595230600944529"},{"key":"e_1_2_19_149_1","unstructured":"Rogers K.2025.\u201cInsulin Shock Therapy.\u201dBritannica.https:\/\/www.britannica.com\/science\/insulin\u2010shock\u2010therapy."},{"key":"e_1_2_19_150_1","doi-asserted-by":"crossref","unstructured":"Ruffalo M. L.2017.\u201cA Brief History of Lithium Treatment in Psychiatry.\u201dPsychiatrist.com.https:\/\/www.psychiatrist.com\/pcc\/history\u2010of\u2010lithium\u2010treatment\u2010in\u2010psychiatry\/.","DOI":"10.4088\/PCC.17br02140"},{"key":"e_1_2_19_151_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugpo.2022.103933"},{"key":"e_1_2_19_152_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp\u2010rj.2021.160405"},{"key":"e_1_2_19_153_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591\u2010022\u201002197\u20100"},{"key":"e_1_2_19_154_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2015.15081082"},{"key":"e_1_2_19_155_1","doi-asserted-by":"publisher","DOI":"10.1192\/j.eurpsy.2021.2216"},{"key":"e_1_2_19_156_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13643\u2010020\u20101274\u20103"},{"key":"e_1_2_19_157_1","doi-asserted-by":"publisher","DOI":"10.1097\/JCP.0000000000001334"},{"key":"e_1_2_19_158_1","doi-asserted-by":"publisher","DOI":"10.3390\/nursrep13040132"},{"key":"e_1_2_19_159_1","doi-asserted-by":"publisher","DOI":"10.2147\/NDT.S486118"},{"key":"e_1_2_19_160_1","unstructured":"St. Louis A.2022.\u201cPower to the People: Using Person\u2010First Language to Make an Important Distinction.\u201dThe Catalyst. Mental Health Commission of Canada.https:\/\/mentalhealthcommission.ca\/catalyst\/power\u2010to\u2010the\u2010people\/#:~:text=in%20all%20situations.\u2010 What's%20the%20difference? t%20live%20with%20bipolar%20disorder."},{"key":"e_1_2_19_161_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2019.00108"},{"key":"e_1_2_19_162_1","doi-asserted-by":"publisher","DOI":"10.1177\/070674371405901S05"},{"key":"e_1_2_19_163_1","doi-asserted-by":"publisher","DOI":"10.1192\/bja.2018.29"},{"key":"e_1_2_19_164_1","doi-asserted-by":"publisher","DOI":"10.14745\/ccdr.v47i01a07"},{"key":"e_1_2_19_165_1","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.45171"},{"key":"e_1_2_19_166_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11606\u2010021\u201006904\u20104"},{"key":"e_1_2_19_167_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.outlook.2024.102342"},{"key":"e_1_2_19_168_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.q2133"},{"key":"e_1_2_19_169_1","unstructured":"Truth & Reconciliation Commission of Canada.2015.\u201cTruth and Reconciliation Commission of Canada: Calls to Action.\u201dGovernment of Canada.https:\/\/publications.gc.ca\/collections\/collection_2015\/trc\/IR4\u20108\u20102015\u2010eng.pdf."},{"key":"e_1_2_19_170_1","unstructured":"United Nations.2021.\u201cUnited Nations Declaration on the Rights of Indigenous Peoples Act.\u201dhttps:\/\/www.un.org\/development\/desa\/Indigenouspeoples\/wp\u2010content\/uploads\/sites\/19\/2018\/11\/UNDRIP_E_web.pdf."},{"key":"e_1_2_19_171_1","unstructured":"United Nations Women.2020.\u201cThe Shadow Pandemic: Violence Against Women During COVID\u201019.\u201dhttps:\/\/www.unwomen.org\/en\/news\/in\u2010focus\/in\u2010focus\u2010gender\u2010equality\u2010in\u2010covid\u201019\u2010response\/violence\u2010against\u2010women\u2010during\u2010covid\u201019."},{"key":"e_1_2_19_172_1","unstructured":"University at Buffalo.2025.\u201cWhat is Trauma\u2010Informed Care?\u201dBuffalo Centre for Social Research.https:\/\/socialwork.buffalo.edu\/social\u2010research\/institutes\u2010centers\/institute\u2010on\u2010trauma\u2010and\u2010trauma\u2010informed\u2010care\/what\u2010is\u2010trauma\u2010informed\u2010care.html#:~:text=healing%20and%20growth. 1 and%20principles%20in%20our%20work."},{"key":"e_1_2_19_173_1","unstructured":"Virtual Health Hub.2025.\u201cVirtual Health Hub: Transforming the Future of Healthcare Delivery.\u201dGovernment of Canada and the Government of Saskatchewan.https:\/\/virtualhealthhub.ca."},{"key":"e_1_2_19_174_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365\u20102125.2012.04167.x"},{"key":"e_1_2_19_175_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpubh.2020.569539"},{"key":"e_1_2_19_176_1","doi-asserted-by":"publisher","DOI":"10.24095\/hpcdp.45.1.02"},{"key":"e_1_2_19_177_1","unstructured":"World Health Organization.2022.\u201cWorld Mental Health Report. Transforming Mental Health for All.\u201dhttps:\/\/www.who.int\/publications\/i\/item\/9789240049338."},{"key":"e_1_2_19_178_1","unstructured":"World Health Organization.2025a.\u201cMental Disorders.\u201dhttps:\/\/www.who.int\/news\u2010room\/fact\u2010sheets\/detail\/mental\u2010disorders#:~:text=A%20mental%20disorder%20is%20characterized and%20violations%20of%20human%20rights."},{"key":"e_1_2_19_179_1","unstructured":"World Health Organization.2025b.\u201cMental Health: Overview.\u201dhttps:\/\/www.who.int\/news\u2010room\/fact\u2010sheets\/detail\/mental\u2010health\u2010strengthening\u2010our\u2010response."},{"key":"e_1_2_19_180_1","unstructured":"World Health Organization.2025c.\u201cSocial Determinants of Health: Overview.\u201dhttps:\/\/www.who.int\/health\u2010topics\/social\u2010determinants\u2010of\u2010health#tab=tab_1."},{"key":"e_1_2_19_181_1","unstructured":"Wyton M.2024.\u201cA Lot of People Are Going to Get Hurt': Nurses Union Doctors Call on Sask. To Reverse Harm Reduction Changes.\u201dCanadian Broadcasting Corporation (CBC) News.https:\/\/www.cbc.ca\/news\/canada\/saskatchewan\/nurses\u2010doctors\u2010harm\u2010reduction\u20101.7093283."},{"key":"e_1_2_19_182_1","unstructured":"Xpress Health.2025.\u201cThe Global Nursing Shortage: Causes Challenges and Solutions.\u201dhttps:\/\/xpresshealth.ie\/the\u2010global\u2010nursing\u2010shortage\u2010causes\u2010challenges\u2010and\u2010solutions."},{"key":"e_1_2_19_183_1","unstructured":"Yale Medicine.2025.\u201cDialectical Behavior Therapy (DBT).\u201dhttps:\/\/www.yalemedicine.org\/conditions\/dialectical\u2010behavior\u2010therapy\u2010dbt."},{"key":"e_1_2_19_184_1","doi-asserted-by":"publisher","DOI":"10.1177\/10105395241303790"},{"key":"e_1_2_19_185_1","doi-asserted-by":"publisher","DOI":"10.2147\/PPA.S422659"}],"container-title":["International Journal of Mental Health Nursing"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/inm.70251","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/inm.70251","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/inm.70251","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,25]],"date-time":"2026-04-25T04:02:49Z","timestamp":1777089769000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/inm.70251"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,28]]},"references-count":185,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,4]]}},"alternative-id":["10.1111\/inm.70251"],"URL":"https:\/\/doi.org\/10.1111\/inm.70251","archive":["Portico"],"relation":{},"ISSN":["1445-8330","1447-0349"],"issn-type":[{"value":"1445-8330","type":"print"},{"value":"1447-0349","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,28]]},"assertion":[{"value":"2026-01-15","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-03","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-28","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70251"}}