{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T10:16:50Z","timestamp":1787134610622,"version":"build-2736575974"},"reference-count":32,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2013,9,12]],"date-time":"2013-09-12T00:00:00Z","timestamp":1378944000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Paed Dentistry"],"published-print":{"date-parts":[[2014,5]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>The study aims to evaluate the change of related subgingival periodontopathogens among different stage of gingivitis in adolescent and assess the relationship between periodontopathogens and the progression of periodontal inflammation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 77 subgingival plaque samples from 35 adolescent individuals were divided into three groups including gingivitis group (mild, 15 samples; moderate, 16 samples; severe, 15 samples), chronic periodontitis group (15 samples) and healthy group (15 samples). Real\u2010time <jats:styled-content style=\"fixed-case\">PCR<\/jats:styled-content> was used to quantitate <jats:italic><jats:styled-content style=\"fixed-case\">P<\/jats:styled-content>orphyromonas gingivalis<\/jats:italic>,<jats:italic> <jats:styled-content style=\"fixed-case\">P<\/jats:styled-content>revotella intermedia<\/jats:italic>,<jats:italic> <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>annerella forsythensis<\/jats:italic>, and <jats:italic><jats:styled-content style=\"fixed-case\">F<\/jats:styled-content>usobacterium nucleatum<\/jats:italic> in subgingival plaque samples.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>All species, except for <jats:italic><jats:styled-content style=\"fixed-case\">F<\/jats:styled-content>.\u00a0nucleatum<\/jats:italic>, were detected in samples from gingivitis and periodontitis groups in significantly greater number than in those from healthy group (<jats:italic>P\u00a0<\/jats:italic>&lt;\u00a00.05). In gingivitis groups, the number of <jats:italic><jats:styled-content style=\"fixed-case\">P<\/jats:styled-content>.\u00a0gingivalis<\/jats:italic>,<jats:italic> <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>.\u00a0forsythensis<\/jats:italic>, and <jats:italic><jats:styled-content style=\"fixed-case\">F<\/jats:styled-content>.\u00a0nucleatum<\/jats:italic> in moderate and severe gingivitis groups was significantly higher than in mild gingivitis group (<jats:italic>P\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0.05). After merging moderate gingivitis and severe gingivitis groups into moderate\u2010to\u2010severe gingivitis group, the four periodontopathogens were detected in samples from periodontitis group in significantly greater number than in those from moderate\u2010to\u2010severe gingivitis group (<jats:italic>P\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The number of <jats:italic><jats:styled-content style=\"fixed-case\">P<\/jats:styled-content>.\u00a0gingivalis<\/jats:italic>,<jats:italic> <jats:styled-content style=\"fixed-case\">P<\/jats:styled-content>.\u00a0intermedia<\/jats:italic>,<jats:italic> <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>.\u00a0forsythensis<\/jats:italic>, and <jats:italic><jats:styled-content style=\"fixed-case\">F<\/jats:styled-content>.\u00a0nucleatum<\/jats:italic> in subgingival plaque increases with progression of periodontal inflammation in adolescents. Examination of periodontopathogens number in adolescents may be of some value for monitoring of periodontal disease development.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ipd.12065","type":"journal-article","created":{"date-parts":[[2013,9,12]],"date-time":"2013-09-12T06:15:27Z","timestamp":1378966527000},"page":"226-233","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":74,"title":["Progression of periodontal inflammation in adolescents is associated with increased number of <i><scp>P<\/scp>orphyromonas gingivalis<\/i>,<i><scp>P<\/scp>revotella intermedia<\/i>,<i><scp>T<\/scp>annerella forsythensis<\/i>, and <i><scp>F<\/scp>usobacterium nucleatum<\/i>"],"prefix":"10.1111","volume":"24","author":[{"given":"Ning\u2010Yan","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Pediatric Dentistry Capital Medical University School of Stomatology Beijing 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