{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T20:32:04Z","timestamp":1777494724057,"version":"3.51.4"},"reference-count":24,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2013,10,17]],"date-time":"2013-10-17T00:00:00Z","timestamp":1381968000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Paed Dentistry"],"published-print":{"date-parts":[[2014,7]]},"abstract":"<jats:sec><jats:title>Aim<\/jats:title><jats:p>This study sought to investigate the effect of caries, in association with physiological root resorption, on the pulpal status of human primary molars.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Fifty\u2010three mandibular primary molars were obtained from children requiring extractions under general anaesthesia. Following extraction, teeth were split longitudinally and placed in Zamboni's fixative. Teeth were categorised according to i) the depth of caries (less than or greater than halfway through dentine thickness) and ii) the degree of physiological root resorption (&lt;33%, 34\u201366% or &gt;67% of the root length). Ten\u2010micrometre pulp sections were subject to indirect immunofluorescence using a combination of <jats:styled-content style=\"fixed-case\">PGP<\/jats:styled-content> 9.5 (a general neuronal marker), <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>45 (a general neuronal marker), and <jats:italic>Ulex europaeus<\/jats:italic> agglutinin I (a marker of vascular endothelium). Image analysis was used to determine the percentage area of staining (<jats:styled-content style=\"fixed-case\">PAS<\/jats:styled-content>) for innervation and immune cells.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Marked differences were seen between different samples, but there were no significant differences in mean <jats:styled-content style=\"fixed-case\">PAS<\/jats:styled-content> for <jats:styled-content style=\"fixed-case\">PGP<\/jats:styled-content> 9.5 or <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>45 according to the degree of caries or extent of physiological root resorption (two\u2010way <jats:sc>anova<\/jats:sc>,<jats:italic> P<\/jats:italic>\u00a0&gt;\u00a00.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Findings suggest that even if primary molars are undergoing exfoliation, they show comparable caries\u2010induced changes to teeth without physiological root resorption, thus retaining potential for healing and repair.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ipd.12070","type":"journal-article","created":{"date-parts":[[2013,10,17]],"date-time":"2013-10-17T07:28:39Z","timestamp":1381994919000},"page":"268-276","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Pulpal status of human primary molars with coexisting caries and physiological root resorption"],"prefix":"10.1111","volume":"24","author":[{"given":"Sadna","family":"Rajan","sequence":"first","affiliation":[{"name":"Department of Paediatric Dentistry Leeds Dental Institute University of Leeds Leeds UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter F.","family":"Day","sequence":"additional","affiliation":[{"name":"Department of Paediatric Dentistry Leeds Dental Institute University of Leeds Leeds 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