{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T19:43:07Z","timestamp":1776973387280,"version":"3.51.4"},"reference-count":30,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2013,11,17]],"date-time":"2013-11-17T00:00:00Z","timestamp":1384646400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Paed Dentistry"],"published-print":{"date-parts":[[2014,7]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>The aetiology of isolated clefts of the lip and\/or palate remains obscure. Unaffected family members are treated as if their genetic risks are equivalent and low. Given the number of genes associated with both clefting and dental anomalies, the hypothesis that such anomalies contribute to the cleft phenotype should be explored.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>To describe the dental characteristics of parents of children with non\u2010syndromic cleft lip\u00a0\u00b1\u00a0palate.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Unaffected parents of <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>ustralian children with a cleft of the lip\u00a0\u00b1\u00a0palate underwent dental examination including radiographs, photographs, and impressions. Dental anomalies were identified.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Data were available on 101 parents (49 males, 52 females). Fifty\u2010one participants had at least one dental anomaly. Twelve (11.8%) individuals had congenital absence of teeth, with seven missing multiple teeth. The tooth most commonly missing was the upper right lateral incisor. Five subjects (4.9%) had microdontia (upper lateral incisor most commonly affected). Four subjects (4.0%) had supernumerary teeth. Enamel defects were present in 27 (26.7%) cases with the incisors (46.8%) followed by premolars (24.2%) most affected.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This study supports previous work suggesting that \u2018unaffected\u2019 parents of children with clefts of the lip\u00a0\u00b1\u00a0palate may present with dental anomalies.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ipd.12072","type":"journal-article","created":{"date-parts":[[2013,11,18]],"date-time":"2013-11-18T02:15:45Z","timestamp":1384740945000},"page":"286-292","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Expanding the cleft phenotype: the dental characteristics of unaffected parents of Australian children with non\u2010syndromic cleft lip and palate"],"prefix":"10.1111","volume":"24","author":[{"given":"Andrea","family":"Aspinall","sequence":"first","affiliation":[{"name":"Murdoch Childrens Research Institute Melbourne Vic. Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Supriya","family":"Raj","sequence":"additional","affiliation":[{"name":"Murdoch Childrens Research Institute Melbourne Vic. Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anil","family":"Jugessur","sequence":"additional","affiliation":[{"name":"Murdoch Childrens Research Institute Melbourne Vic. Australia"},{"name":"Department of Genes and Environment Norwegian Institute of Public Health Oslo Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mary","family":"Marazita","sequence":"additional","affiliation":[{"name":"Centre for Craniofacial and Dental Genetics University of Pittsburgh Pittsburgh PA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ravi","family":"Savarirayan","sequence":"additional","affiliation":[{"name":"Victorian Clinical Genetics Service Royal Children's Hospital Melbourne Vic. Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicky","family":"Kilpatrick","sequence":"additional","affiliation":[{"name":"Murdoch Childrens Research Institute Melbourne Vic. 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