{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T15:47:14Z","timestamp":1792165634756,"version":"4.4.0"},"reference-count":30,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2013,12,25]],"date-time":"2013-12-25T00:00:00Z","timestamp":1387929600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Paed Dentistry"],"published-print":{"date-parts":[[2014,11]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Oral mucositis is a debilitating side effect of chemotherapy. Laser therapy has recently demonstrated efficacy in the management of oral mucositis (<jats:styled-content style=\"fixed-case\">OM<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>This prospective study was conducted to evaluate the efficacy of class <jats:styled-content style=\"fixed-case\">IV<\/jats:styled-content> laser therapy in patients affected by <jats:styled-content style=\"fixed-case\">OM<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Eighteen onco\u2010haematological paediatric patients receiving chemotherapy and\/or haematopoietic stem cell transplantation, prior to total body irradiation, affected by <jats:styled-content style=\"fixed-case\">OM<\/jats:styled-content>, were enrolled in this study. Patients were treated with class <jats:styled-content style=\"fixed-case\">IV<\/jats:styled-content> laser therapy for four consecutive days; the assessment of <jats:styled-content style=\"fixed-case\">OM<\/jats:styled-content> was performed through <jats:styled-content style=\"fixed-case\">WHO<\/jats:styled-content> Oral Mucositis Grading Objective Scale, and pain was evaluated through visual analogue scale. Patients completed a validated questionnaire, and photographs of lesions were taken during each session. Patients were re\u2010evaluated 11\u00a0days after the first day of laser therapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>All patients demonstrated improvement in pain sensation, and all mucositis was fully resolved at the 11\u2010day follow\u2010up visit, with no apparent side effects. Laser therapy was well tolerated with remarkable reduction in pain associated with oral mucositis after 1\u20132\u00a0days of laser therapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Given class <jats:styled-content style=\"fixed-case\">IV<\/jats:styled-content> laser therapy appears to be safe, non\u2010invasive, and potentially effective, prospective, randomized, controlled trials are necessary to further assess efficacy and to determine optimal treatment parameters.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ipd.12090","type":"journal-article","created":{"date-parts":[[2013,12,26]],"date-time":"2013-12-26T04:26:50Z","timestamp":1388032010000},"page":"441-449","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":46,"title":["Class <scp>IV<\/scp> laser therapy as treatment for chemotherapy\u2010induced oral mucositis in onco\u2010haematological paediatric patients: a prospective study"],"prefix":"10.1111","volume":"24","author":[{"given":"Maddalena","family":"Chermetz","sequence":"first","affiliation":[{"name":"Division of Oral Medicine and Pathology Department of Dental Science University of Trieste Trieste Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margherita","family":"Gobbo","sequence":"additional","affiliation":[{"name":"Division of Oral Medicine and Pathology Department of Dental Science University of Trieste Trieste Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luca","family":"Ronfani","sequence":"additional","affiliation":[{"name":"Institute for Maternal and Child Health IRCCS Burlo Garofolo Trieste Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giulia","family":"Ottaviani","sequence":"additional","affiliation":[{"name":"Division of Oral Medicine and Pathology Department of Dental Science University of Trieste Trieste Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giulio A.","family":"Zanazzo","sequence":"additional","affiliation":[{"name":"Institute for Maternal and Child Health IRCCS Burlo Garofolo Trieste Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federico","family":"Verzegnassi","sequence":"additional","affiliation":[{"name":"Institute for Maternal and Child Health IRCCS Burlo Garofolo Trieste Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathaniel S.","family":"Treister","sequence":"additional","affiliation":[{"name":"Division of Oral Medicine &amp; 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