{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T19:59:29Z","timestamp":1760299169628},"reference-count":5,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2015,7,4]],"date-time":"2015-07-04T00:00:00Z","timestamp":1435968000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"National Council for Scientific and Technological Development-CNPq, Bras\u00edlia, Brazil."},{"name":"The State of Minas Gerais Research Foundation-FAPEMIG, Minas Gerais, Brazil"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Paed Dentistry"],"published-print":{"date-parts":[[2016,1]]},"abstract":"Background<\/jats:title>Fanconi syndrome (FS<\/jats:styled-content>) is a generalized dysfunction of renal proximal tubules resulting in impaired reabsorption of amino acids, phosphate, urate, bicarbonate, glucose, and electrolytes. FS<\/jats:styled-content> can be a primary renal impairment due to genetic origin or secondary to inborn errors of metabolism or systemic diseases. Main clinical findings are polyuria, failure to thrive, rickets\/osteomalacia, metabolic acidosis, bone deformities, and, occasionally, nephrocalcinosis. Although dental abnormalities have been reported in patients with tubulopathies, oral manifestations in FS<\/jats:styled-content> were very rarely described.<\/jats:p><\/jats:sec>Case report<\/jats:title>Two patients with FS<\/jats:styled-content> exhibiting important dental alterations were reported. Oral examination of the first patient revealed teeth with rough surfaces and white opaque areas. Early loss of primary teeth and delayed eruption of permanent teeth were also observed. Oral examination of the second patient detected delayed eruption of permanent teeth and X\u2010ray images revealed loss of contrast between enamel and dentin. In both patients with FS<\/jats:styled-content>, loss of bone density in maxilla and mandible was observed in X\u2010ray images.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>This study is the first report of dental abnormalities in Brazilian patients with FS<\/jats:styled-content>. Furthermore, our findings support the general idea that renal tubular disorders might impact on mineralized tissues of the oral cavity.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ipd.12183","type":"journal-article","created":{"date-parts":[[2015,7,4]],"date-time":"2015-07-04T07:47:09Z","timestamp":1435996029000},"page":"77-80","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Dental findings in Brazilian patients with Fanconi syndrome"],"prefix":"10.1111","volume":"26","author":[{"given":"Shirlene B. P.","family":"Ferreira","sequence":"first","affiliation":[{"name":"Health Science Program State University of Montes Claros Unimontes Minas Gerais Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sibele N.","family":"de Aquino","sequence":"additional","affiliation":[{"name":"School of Dentistry Federal University of Juiz de Fora Governador Valadares Minas Gerais Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paula Cristina B.","family":"Pereira","sequence":"additional","affiliation":[{"name":"Unit of Pediatric Nephrology Department of Pediatrics Interdisciplinary Laboratory of Medical Investigation Federal University of Minas Gerais UFMG Belo Horizonte Minas Gerais Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana Cristina","family":"Sim\u00f5es e Silva","sequence":"additional","affiliation":[{"name":"Unit of Pediatric Nephrology Department of Pediatrics Interdisciplinary Laboratory of Medical Investigation Federal University of Minas Gerais UFMG Belo Horizonte Minas Gerais Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Herc\u00edlio","family":"Martelli\u2010J\u00fanior","sequence":"additional","affiliation":[{"name":"Health Science Program State University of Montes Claros Unimontes Minas Gerais Brazil"},{"name":"Stomatology Clinic Dental School State University of Montes Claros Unimontes Montes Claros Minas Gerais Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,7,4]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1307581"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfp063"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.2174\/138920209787581262"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1159\/000345801"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0030-4220(89)90188-6"}],"container-title":["International Journal of Paediatric Dentistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fipd.12183","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ipd.12183","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T10:21:34Z","timestamp":1696242094000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ipd.12183"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,7,4]]},"references-count":5,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2016,1]]}},"alternative-id":["10.1111\/ipd.12183"],"URL":"https:\/\/doi.org\/10.1111\/ipd.12183","archive":["Portico"],"relation":{},"ISSN":["0960-7439","1365-263X"],"issn-type":[{"value":"0960-7439","type":"print"},{"value":"1365-263X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,7,4]]},"assertion":[{"value":"2015-07-04","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}