{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T02:22:31Z","timestamp":1784254951435,"version":"3.55.0"},"reference-count":39,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2015,9,15]],"date-time":"2015-09-15T00:00:00Z","timestamp":1442275200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004366","name":"Tabriz University of Medical Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004366","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Paed Dentistry"],"published-print":{"date-parts":[[2016,7]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>This study aimed to examine the efficacy of 3Mixtatin (a combination of simvastatin and 3Mix antibiotic) as a novel pulp capping biomaterial in<jats:styled-content style=\"fixed-case\">DPC<\/jats:styled-content>of human primary molars.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this randomized clinical trial, 160 primary molars from 83 healthy children aged 3\u20136 years were randomly allocated into four groups. Small traumatic non\u2010caries pulpal exposures were treated by<jats:styled-content style=\"fixed-case\">DPC<\/jats:styled-content>using simvastatin, 3Mix, 3Mixtatin, or<jats:styled-content style=\"fixed-case\">MTA<\/jats:styled-content>. Capping materials were covered with hard\u2010setting zinc oxide eugenol (<jats:styled-content style=\"fixed-case\">ZOE<\/jats:styled-content>) cement, and then, teeth were restored with amalgam. Clinical and radiographic examinations were conducted at 2, 6, and 12 months after treatment. The data were compared using chi\u2010square test at a significance level of 0.05.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>One hundred and twenty\u2010nine teeth were available for follow\u2010up study. By the end of 12 months, the overall success rates were 93.8% in<jats:styled-content style=\"fixed-case\">MTA<\/jats:styled-content>, 91.9% in 3Mixtatin, 62.5% in 3Mix, and 57.1% in simvastatingroups. No statistically significant difference was found between the outcomes of<jats:styled-content style=\"fixed-case\">MTA<\/jats:styled-content>and 3Mixtatin groups (<jats:italic>P<\/jats:italic>&gt; 0.05). 3Mixtatin had statistically superior results compared to 3Mix and simvastatin (<jats:italic>P<\/jats:italic>&lt; 0.01).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Radiographic and clinical outcomes in 3Mixtatin group could suggest it as an acceptable alternative in<jats:styled-content style=\"fixed-case\">DPC<\/jats:styled-content>of primary molar teeth.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ipd.12196","type":"journal-article","created":{"date-parts":[[2015,9,15]],"date-time":"2015-09-15T07:37:32Z","timestamp":1442302652000},"page":"281-290","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":44,"title":["A randomized trial of direct pulp capping in primary molars using<scp>MTA<\/scp>compared to 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