{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T13:22:22Z","timestamp":1761744142590},"reference-count":27,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2015,9,15]],"date-time":"2015-09-15T00:00:00Z","timestamp":1442275200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Paed Dentistry"],"published-print":{"date-parts":[[2016,9]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To examine whether panoramic radiograph\u2010determined mandibular cortical thickness correlated with quantitative computed tomography\u2010derived bone mineral density (<jats:styled-content style=\"fixed-case\">BMD<\/jats:styled-content>) in survivors of childhood acute lymphoblastic leukemia (<jats:styled-content style=\"fixed-case\">ALL<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We identified patients treated for <jats:styled-content style=\"fixed-case\">ALL<\/jats:styled-content> at St. Jude Children's Research Hospital, seen in the After Completion of Therapy (<jats:styled-content style=\"fixed-case\">ACT<\/jats:styled-content>) Clinic between January of 2006 and January of 2014 who had <jats:styled-content style=\"fixed-case\">QCT<\/jats:styled-content>\u2010derived <jats:styled-content style=\"fixed-case\">BMD<\/jats:styled-content> and panoramic radiographs obtained within 1 month of each other. Panoramic radiographs were independently scored by a pediatric radiologist, two pediatric dentists, and a general dentist using the Klemetti technique. We used the Spearman's rank correlation test and the multivariate regression model to investigate the effect of evaluator experience on results.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The study cohort comprised 181 patients with 320 paired studies: 112 (62%) male, 112 (71%) were white. Median age at <jats:styled-content style=\"fixed-case\">ALL<\/jats:styled-content> diagnosis was 6.4 (range, 0\u201318.8) years. Median age at study was 11.9 (range, 3.3 to 29.4) years. The median average <jats:styled-content style=\"fixed-case\">BMD<\/jats:styled-content> was 154.6 (range, 0.73\u2013256) mg\/cc; median <jats:styled-content style=\"fixed-case\">QCT<\/jats:styled-content> Z\u2010score (age and gender adjusted) was \u22120.875 (range, \u22125.04 to 3.2). We found very weak association between panoramic radiograph score and both <jats:styled-content style=\"fixed-case\">QCT<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">BMD<\/jats:styled-content> average (<jats:italic>P<\/jats:italic> = 0.53) and <jats:styled-content style=\"fixed-case\">QCT<\/jats:styled-content> Z\u2010score (<jats:italic>P<\/jats:italic> = 0.39). Results were not influenced by level of reader experience.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The Klemetti technique of estimating <jats:styled-content style=\"fixed-case\">BMD<\/jats:styled-content> does not predict <jats:styled-content style=\"fixed-case\">BMD<\/jats:styled-content> deficits in children and young adult survivors of <jats:styled-content style=\"fixed-case\">ALL<\/jats:styled-content>, regardless of reviewer expertise. Alternative methods are needed whereby dental healthcare providers can identify and refer patients at risk for <jats:styled-content style=\"fixed-case\">BMD<\/jats:styled-content> deficits for detailed assessment and intervention.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ipd.12203","type":"journal-article","created":{"date-parts":[[2015,9,15]],"date-time":"2015-09-15T07:29:28Z","timestamp":1442302168000},"page":"330-335","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Comparison of mandibular cortical thickness and <scp>QCT<\/scp>\u2010derived bone mineral density (<scp>BMD<\/scp>) in survivors of childhood acute lymphoblastic leukemia: a retrospective study"],"prefix":"10.1111","volume":"26","author":[{"given":"Brandice","family":"Allen","sequence":"first","affiliation":[{"name":"Department of Pediatric Dentistry University of Tennessee Health Science Center College of Dentistry Memphis TN 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