{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T01:26:40Z","timestamp":1759541200053,"version":"3.37.3"},"reference-count":39,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2015,10,6]],"date-time":"2015-10-06T00:00:00Z","timestamp":1444089600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Paed Dentistry"],"published-print":{"date-parts":[[2016,9]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Coeliac disease is a chronic small intestinal immune\u2010mediated enteropathy precipitated by exposure to dietary gluten, and possible relationships between coeliac disease and dental pathogenic conditions during childhood have been poorly investigated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>The dental pulp plays a pivotal role in the immune defence against possible entry of pathogens from teeth, and the aim of this work was to investigate quantitative transcription levels of selected genes (<jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20109, <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201011, <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201015, <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201018, <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201021, <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201027, <jats:styled-content style=\"fixed-case\">MICA<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> IFN<\/jats:styled-content>\u2010<jats:italic>\u03b3<\/jats:italic>) coding for pro\u2010inflammatory immune innate activities in the pulp of primary teeth from healthy children and children with coeliac disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>The pulp from primary teeth of 10 healthy children and 10 children with coeliac disease was used to extract <jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content> and prepare <jats:styled-content style=\"fixed-case\">cDNA<\/jats:styled-content> for quantitative <jats:styled-content style=\"fixed-case\">PCR<\/jats:styled-content> transcription analysis employing commercial nucleotide probes for selected genes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In children with coeliac disease, the genes coding for pro\u2010inflammatory cytokines <jats:styled-content style=\"fixed-case\">IFN<\/jats:styled-content>\u2010<jats:italic>\u03b3<\/jats:italic>,<jats:styled-content style=\"fixed-case\"> IL<\/jats:styled-content>\u201011, <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201018, and <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201021 were significantly overexpressed, suggesting the possible importance of these cytokines in the relationships between coeliac disease and dental disorders.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>For the first time, we reported in dental pulp of children possible relationships between coeliac disease and modulation in transcription of cytokine\u2010dependent inflammatory activities.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ipd.12207","type":"journal-article","created":{"date-parts":[[2015,10,6]],"date-time":"2015-10-06T13:49:15Z","timestamp":1444139355000},"page":"351-356","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Altered transcription of inflammation\u2010related genes in dental pulp of coeliac 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