{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T05:41:48Z","timestamp":1761716508682,"version":"3.37.3"},"reference-count":29,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2018,10,9]],"date-time":"2018-10-09T00:00:00Z","timestamp":1539043200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Paed Dentistry"],"published-print":{"date-parts":[[2019,1]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Rapid maxillary expansion (<jats:styled-content style=\"fixed-case\">RME<\/jats:styled-content>) is an orthopaedic procedure indicated for a wide variety of clinical conditions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>The aim of the study was to compare the effects of ketoprofen lysine\u00a0salt (<jats:styled-content style=\"fixed-case\">KLS<\/jats:styled-content>) vs paracetamol\/acetaminophen (P) on pain perception during <jats:styled-content style=\"fixed-case\">RME<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>One hundred and fifty\u2010one subjects (mean age 8.6\u00a0year) were enrolled in this prospective controlled clinical trial according to inclusion criteria: prepuberal stage of development, negative posterior transverse interarch discrepancy, non\u2010concurrent use of other drugs.<\/jats:p><jats:p>First phase: n.40 allocated to Group 1 used 40\u00a0mg of <jats:styled-content style=\"fixed-case\">KLS<\/jats:styled-content>, n.40 to Group 2 used 250\u00a0mg of P, n.36 to Group 3 as control group. Second phase: n.35 allocated to Group 4 used 40\u00a0mg ketoprofen lysine salt once a day for the first 3\u00a0days of activation.<\/jats:p><jats:p>Pain experience was reported on a numeric rating scale (0\u20104) and a 100\u2010mm visual analogue scale. Pain perception was tested with the Mann\u2010Whitney test (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Pain perception was higher during the first 3\u00a0days of activation and it was described as mild to moderate. Group 1 experienced significantly less pain during the fourth, fifth, and sixth day (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05) compared with Group 2. Patients of the Group 4 reported significantly lower pain during the whole period of <jats:styled-content style=\"fixed-case\">RME<\/jats:styled-content> activation (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The perceived higher pain was reported during the second and\u00a0third day of expansion. The analgesic effect of <jats:styled-content style=\"fixed-case\">KLS<\/jats:styled-content> is more effective than\u00a0P during the fourth, fifth, and sixth day. The use of <jats:styled-content style=\"fixed-case\">KLS<\/jats:styled-content> during the first 3\u00a0days of activation seems to be able reducing pain during the whole active phase.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ipd.12428","type":"journal-article","created":{"date-parts":[[2018,10,9]],"date-time":"2018-10-09T07:21:23Z","timestamp":1539069683000},"page":"58-65","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Efficacy of ketoprofen lysine salt and paracetamol\/acetaminophen to reduce pain during rapid maxillary expansion: A randomized controlled clinical trial"],"prefix":"10.1111","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6442-5591","authenticated-orcid":false,"given":"Gianguido","family":"Cossellu","sequence":"first","affiliation":[{"name":"Department of Biomedical Surgical and Dental Sciences University of Milan Milan 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