{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T10:25:54Z","timestamp":1784111154685,"version":"3.55.0"},"reference-count":28,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2019,2,14]],"date-time":"2019-02-14T00:00:00Z","timestamp":1550102400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2015\/06866\u20105"],"award-info":[{"award-number":["2015\/06866\u20105"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2015\/09034\u20100"],"award-info":[{"award-number":["2015\/09034\u20100"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Paed Dentistry"],"published-print":{"date-parts":[[2019,5]]},"abstract":"Background<\/jats:title>Tooth eruption is a process that is not fully understood.<\/jats:p><\/jats:sec>Aim<\/jats:title>To evaluate whether genetic polymorphisms for RANK<\/jats:styled-content>\/RANKL<\/jats:styled-content>\/OPG<\/jats:styled-content> are associated with delayed tooth emergence. To evaluate whether the relative expression of this genes is associated with persistent primary teeth.<\/jats:p><\/jats:sec>Design<\/jats:title>To evaluate whether genetic polymorphisms for RANK<\/jats:styled-content>\/RANKL<\/jats:styled-content>\/OPG<\/jats:styled-content> could be involved in delayed tooth emergence, saliva samples from 160 children, aged 6\u201013\u00a0years old, were analysed. To test if there is correlation between gene expression of RANK<\/jats:styled-content>\/RANKL<\/jats:styled-content>\/OPG<\/jats:styled-content> in children with delayed tooth emergence and persistent primary teeth, periapical tissue from 15 children with persistent primary teeth and from 15 control subjects were collected for qPCR<\/jats:styled-content> analysis.<\/jats:p><\/jats:sec>Results<\/jats:title>Fifty\u2010six children with delayed tooth emergence (35%) had at least one permanent tooth with delayed emergence. The T allele in RANKL<\/jats:styled-content><\/jats:italic> (rs9594738) increased the risk of delayed tooth emergence (P<\/jats:italic>\u00a0=\u00a00.02; OR<\/jats:styled-content>\u00a0=\u00a01.71, 95%CI<\/jats:styled-content> 1.09\u20102.75). The relative gene expression for RANKL<\/jats:styled-content> and the ratio RANKL<\/jats:styled-content>\/OPG<\/jats:styled-content> in children with delayed tooth emergence and persistent primary teeth were lower compared to controls (P<\/jats:italic>\u00a0=\u00a00.02 and P<\/jats:italic>\u00a0=\u00a00.005, respectively).<\/jats:p><\/jats:sec>Conclusions<\/jats:title>Data suggest that the polymorphism rs9594738 in RANKL<\/jats:styled-content><\/jats:italic> is associated with delayed permanent tooth emergence. Moreover, reduced relative gene expression of RANKL<\/jats:styled-content> in periapical tissue is associated with persistent primary teeth.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ipd.12467","type":"journal-article","created":{"date-parts":[[2019,1,18]],"date-time":"2019-01-18T06:20:19Z","timestamp":1547792419000},"page":"294-300","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["RANKL<\/scp> is associated with persistent primary teeth and delayed permanent tooth emergence"],"prefix":"10.1111","volume":"29","author":[{"given":"Juliana","family":"Arid","sequence":"first","affiliation":[{"name":"Department of Pediatric Dentistry University of S\u00e3o Paulo \u2010 School of Dentistry of Ribeir\u00e3o Preto Ribeir\u00e3o Preto S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8328-9337","authenticated-orcid":false,"given":"Tha\u00eds Aparecida","family":"Xavier","sequence":"additional","affiliation":[{"name":"Department of Pediatric Dentistry University of S\u00e3o Paulo \u2010 School of Dentistry of Ribeir\u00e3o Preto Ribeir\u00e3o Preto S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raquel Assed Bezerra","family":"da Silva","sequence":"additional","affiliation":[{"name":"Department of Pediatric Dentistry University of S\u00e3o Paulo \u2010 School of Dentistry of Ribeir\u00e3o Preto Ribeir\u00e3o Preto S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andiara","family":"De Rossi","sequence":"additional","affiliation":[{"name":"Department of Pediatric Dentistry University of S\u00e3o Paulo \u2010 School of Dentistry of Ribeir\u00e3o Preto Ribeir\u00e3o Preto S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lea Assed Bezerra","family":"da Silva","sequence":"additional","affiliation":[{"name":"Department of Pediatric Dentistry University of S\u00e3o Paulo \u2010 School of Dentistry of Ribeir\u00e3o Preto Ribeir\u00e3o Preto S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2900-5000","authenticated-orcid":false,"given":"Alexandra Mussolino","family":"de Queiroz","sequence":"additional","affiliation":[{"name":"Department of Pediatric Dentistry University of S\u00e3o Paulo \u2010 School of Dentistry of Ribeir\u00e3o Preto Ribeir\u00e3o Preto S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9195-7689","authenticated-orcid":false,"given":"Rodrigo","family":"Galo","sequence":"additional","affiliation":[{"name":"Department of Dentistry Federal University of Vale do Jequitinhonha and Mucuri Diamantina Minas Gerais 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