{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T19:50:57Z","timestamp":1784663457844,"version":"3.55.0"},"reference-count":36,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2019,6,11]],"date-time":"2019-06-11T00:00:00Z","timestamp":1560211200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Paed Dentistry"],"published-print":{"date-parts":[[2019,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Temporomandibular disorder (TMD) is a multifactorial condition that combines environmental and genetic factors and its prevalence increases during adolescence.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>To investigate the association between TMD and genetic polymorphisms in the <jats:italic>DRD2<\/jats:italic> and <jats:italic>ANKK1<\/jats:italic> in a population of Brazilian adolescents.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>The TMD group included adolescents diagnosed with any of the following TMD subgroups according to the RDC\/TMD criteria: myofascial pain, arthralgia and disc displacement and painful TMD. Genomic DNA for molecular analysis was extracted from buccal cells, and genetic polymorphism <jats:italic>rs6275<\/jats:italic> in <jats:italic>DRD2<\/jats:italic> and <jats:italic>rs1800497<\/jats:italic> in <jats:italic>ANKK1<\/jats:italic> were genotyped by real\u2010time polymerase chain reactions using the TaqMan assay. Data were analysed using the Epi Info 3.5.7 and Stata software, with significance level of 0.05.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Two hundred fifty\u2010one individuals were included in this study, 148 subjects presented TMD. For disc displacement, the genetic polymorphisms <jats:italic>rs6275<\/jats:italic> was associated in a recessive model (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.04), whereas the rs6276 and rs1800497 presented only a borderline association in a recessive and dominant models, respectively (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.07 and <jats:italic>P<\/jats:italic>\u00a0=\u00a00.06).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The genetic polymorphism rs6275 in <jats:italic>DRD2<\/jats:italic> was associated with disc displacement in Brazilian adolescents.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ipd.12544","type":"journal-article","created":{"date-parts":[[2019,5,30]],"date-time":"2019-05-30T10:33:41Z","timestamp":1559212421000},"page":"748-755","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Dopamine receptor D2 and ankyrin repeat domain containing one in temporomandibular 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