{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T03:50:18Z","timestamp":1792036218069,"version":"4.4.0"},"reference-count":28,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2019,9,18]],"date-time":"2019-09-18T00:00:00Z","timestamp":1568764800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Paed Dentistry"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Untreated caries on primary molars often leads to pulp inflammation and extraction.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>To retrospectively investigate the effect of pulp inflammation and extraction of primary molars on their successors regarding alignment in the dental arch and developmental enamel defects (DED).<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>The participants in this study were children at public schools in Petropolis (Brazil), who participated in a 3\u2010year longitudinal clinical trial. Children (N\u00a0=\u00a044) were selected for the present study if they had at least one erupted premolar of which the predecessor primary molar presented pulp inflammation at baseline or during any of the 6\u2010month follow\u2010up assessments. All premolars were examined for DED and misalignment. Distinction was made between extraction performed before (E &lt;8) or after the age of 8\u00a0years (E \u22658). Distinction was also made between pulp inflammation occurred before (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a07) or after the age of 7\u00a0years (<jats:italic>P<\/jats:italic>\u00a0\u2265\u00a07). A logistic regression analysis was performed, and the odds ratio was calculated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results and conclusions<\/jats:title><jats:p>Misalignment occurred more frequently in E &lt;8 as compared to E \u22658 (OR\u00a0=\u00a02.85; <jats:italic>P<\/jats:italic>\u00a0=\u00a0.03). There was no significant difference in DED between <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a07 and <jats:italic>P<\/jats:italic>\u00a0\u2265\u00a07.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Misalignment of premolars occurs more frequently when the predecessor primary molars are extracted before the age of 8\u00a0years.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ipd.12568","type":"journal-article","created":{"date-parts":[[2019,8,8]],"date-time":"2019-08-08T13:28:52Z","timestamp":1565270932000},"page":"18-26","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["The effect of pulp inflammation and premature extraction of primary molars on the successor permanent teeth. A retrospective study"],"prefix":"10.1111","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7078-8142","authenticated-orcid":false,"given":"Fawn Nitanee","family":"van der Weijden","sequence":"first","affiliation":[{"name":"Department of Orthodontics Academic Centre of Dentistry Amsterdam Amsterdam The Netherlands"},{"name":"Department of Paediatric Dentistry Academic Centre for Dentistry Amsterdam Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0912-4152","authenticated-orcid":false,"given":"Daniela","family":"Hesse","sequence":"additional","affiliation":[{"name":"Department of Paediatric Dentistry Academic Centre for Dentistry Amsterdam Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8164-6572","authenticated-orcid":false,"given":"Gabriela Caldeira Andrade","family":"Americano","sequence":"additional","affiliation":[{"name":"Department of Paediatric Dentistry Universidade do Estado do Rio de Janeiro Rio de Janeiro Brazil"},{"name":"Dental School, Faculdade Arthur S\u00e1 Earp Neto Petr\u00f3polis Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0572-3174","authenticated-orcid":false,"given":"Vera Mendes","family":"Soviero","sequence":"additional","affiliation":[{"name":"Department of Paediatric Dentistry Universidade do Estado do Rio de Janeiro Rio de Janeiro Brazil"},{"name":"Dental School, Faculdade Arthur S\u00e1 Earp Neto Petr\u00f3polis Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6515-2927","authenticated-orcid":false,"given":"Clarissa Calil","family":"Bonifacio","sequence":"additional","affiliation":[{"name":"Department of Paediatric Dentistry Academic Centre for Dentistry Amsterdam Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,9,18]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/ipd.12451"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/ipd.12416"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11136-015-1059-7"},{"issue":"6","key":"e_1_2_8_5_1","first-page":"501","article-title":"Injury to the teeth of succession by abscess of the temporary teeth","volume":"34","author":"McCormick J","year":"1967","journal-title":"J Dent Child"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9416(71)90214-4"},{"key":"e_1_2_8_7_1","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1007\/978-90-313-7532-5","volume-title":"Gebitsontwikkeling bij de mens","author":"Linden F","year":"2010"},{"issue":"6","key":"e_1_2_8_8_1","first-page":"e1","article-title":"Space loss following premature loss of primary second molars","volume":"63","author":"Alnahwi HH","year":"2015","journal-title":"Gen Dent"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02174357"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1159\/000073400"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1177\/154405910508400310"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/0096-6347(46)90015-4"},{"issue":"3","key":"e_1_2_8_13_1","first-page":"109","article-title":"A radiographic study of mineralization of permanent teeth in a group of children aged 3\u20137 years","volume":"84","author":"Nielsen HG","year":"1976","journal-title":"Scand J Dent Res"},{"issue":"3","key":"e_1_2_8_14_1","first-page":"379","article-title":"Development of the human jaws and surrounding structures from birth to the age of fifteen years","volume":"20","author":"Logan W","year":"1933","journal-title":"J Am Dent Assoc"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijsu.2014.07.014"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0528.2009.00514.x"},{"issue":"4","key":"e_1_2_8_17_1","first-page":"274","article-title":"A detailed consideration of the line of occlusion","volume":"48","author":"Ricketts RM","year":"1978","journal-title":"Angle Orthod"},{"key":"e_1_2_8_18_1","first-page":"751","volume-title":"Contemporary orthodontics","author":"Proffit WR","year":"2007"},{"issue":"6","key":"e_1_2_8_19_1","first-page":"411","article-title":"A review of the developmental defects of enamel index (DDE Index). 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