{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T01:19:43Z","timestamp":1747185583166,"version":"3.40.5"},"reference-count":30,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2019,9,12]],"date-time":"2019-09-12T00:00:00Z","timestamp":1568246400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100005363","name":"Universidad de Buenos Aires","doi-asserted-by":"publisher","award":["UBACyT Grant 2014\u20102017 20020130100270"],"award-info":[{"award-number":["UBACyT Grant 2014\u20102017 20020130100270"]}],"id":[{"id":"10.13039\/501100005363","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005363","name":"Universidad de Buenos Aires","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005363","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Paed Dentistry"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Heavy metals including Cr VI are present in inadequately treated effluents that contaminate drinking water. Hence, Cr VI exposure can affect children through intake of breast milk from an exposed mother or bottle\u2010feeding formula prepared with contaminated water. To date, there are no reports on the effects of Cr VI exposure on tooth formation processes concomitant to tooth eruption.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>To study the effect of Cr VI exposure on tooth tissue formation in suckling Wistar rats by assessing dental tissues at different stages of tooth eruption.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Experimental animals received 12.5\u00a0mg\/kg body weight\/day of a potassium dichromate solution by gavage; control animals were similarly administered an equivalent volume of saline solution. Each group was divided into three subsets according to age at euthanasia: 9, 15, and 23\u00a0days. Dental formation was analysed histologically and histomorphometrically. Statistical analysis: Student's <jats:italic>t<\/jats:italic> test; <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.05.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Cr VI\u2010exposed animals showed a delay in mineralized crown and root tissue formation. These findings are directly associated with the observed delay in tooth eruption.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our findings show the importance of monitoring drinking water levels of toxic substances, since exposure during early childhood can alter tooth formation, growth, and development.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ipd.12573","type":"journal-article","created":{"date-parts":[[2019,8,28]],"date-time":"2019-08-28T22:39:31Z","timestamp":1567031971000},"page":"35-41","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Alterations in odontogenesis and tooth eruption resulting from exposure to hexavalent chromium in suckling animals"],"prefix":"10.1111","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5987-4405","authenticated-orcid":false,"given":"Luciana Marina","family":"S\u00e1nchez","sequence":"first","affiliation":[{"name":"Universidad de Buenos Aires Facultad de Odontolog\u00eda C\u00e1tedra de Histolog\u00eda y Embriolog\u00eda Buenos Aires Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u00c1ngela Matilde","family":"Ubios","sequence":"additional","affiliation":[{"name":"Universidad de Buenos Aires Facultad de Odontolog\u00eda C\u00e1tedra de Histolog\u00eda y Embriolog\u00eda Buenos Aires Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,9,12]]},"reference":[{"key":"e_1_2_8_2_1","first-page":"341905","article-title":"Mechanism of human tooth eruption: review article including a new theory for future studies on the eruption process","volume":"2014","author":"Kj\u00e6r I","year":"2014","journal-title":"Scientifica (Cairo)"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00223-010-9366-z"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjan.2013.10.012"},{"key":"e_1_2_8_5_1","first-page":"30","article-title":"Vitamin D and its impact on oral health\u2013an update","volume":"91","author":"Stein SH","year":"2011","journal-title":"Tenn Dent Assoc"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1203\/01.PDR.0000180599.54807.24"},{"key":"e_1_2_8_7_1","first-page":"529","article-title":"Cleidocranial dysplasia: maxillary alterations on the transverse plane. 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