{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T00:48:53Z","timestamp":1771548533425,"version":"3.50.1"},"reference-count":12,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2020,2,25]],"date-time":"2020-02-25T00:00:00Z","timestamp":1582588800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Paed Dentistry"],"published-print":{"date-parts":[[2020,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Dental caries represents one of the most common human diseases which can lead to pulpitis, pain, and tooth loss and can negatively affect growth and well\u2010being. Although dietary and environmental factors have been extensively studied towards their contribution of the disease, genetic factors that contribute one's susceptibility over caries development remain rather clouded.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>To investigate the possible contribution of <jats:italic>ACTN2<\/jats:italic> (rs6656267) and <jats:italic>MPPED2<\/jats:italic> (rs11031093 and rs536007) polymorphisms in primary dentition caries.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Samples from children (5\u201012\u00a0years old) were collected and genotyped for <jats:italic>ACTN2<\/jats:italic> (rs6656267) and <jats:italic>MPPED2<\/jats:italic> (rs11031093 and rs536007) polymorphisms. With regard to dmfs index and socio\u2010economic status, an association between these polymorphisms and primary dentition caries was investigated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p><jats:italic>ACTN2<\/jats:italic> (rs6655267) and <jats:italic>MPPED2<\/jats:italic> (rs536007) are not associated with primary dentition caries. <jats:italic>MPPED2<\/jats:italic> (rs11031093, G Allele) is marginally associated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p><jats:italic>MPPED2<\/jats:italic> (rs11031093, G Allele) is marginally associated with caries susceptibility on primary dentition.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ipd.12627","type":"journal-article","created":{"date-parts":[[2020,2,10]],"date-time":"2020-02-10T14:20:45Z","timestamp":1581344445000},"page":"478-482","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["<i>ACTN2<\/i> (rs6656267) and <i>MPPED2<\/i> (rs11031093 and rs536007) polymorphisms in primary dentition caries: A case\u2010control study"],"prefix":"10.1111","volume":"30","author":[{"given":"Hector","family":"Katifelis","sequence":"first","affiliation":[{"name":"Laboratory of Biology, Medical School National and Kapodistrian University of Athens Athens Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Sioziou","sequence":"additional","affiliation":[{"name":"Laboratory of Biology, Medical School National and Kapodistrian University of Athens Athens Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3295-6811","authenticated-orcid":false,"given":"Maria","family":"Gazouli","sequence":"additional","affiliation":[{"name":"Laboratory of Biology, Medical School National and Kapodistrian University of Athens Athens Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dimitris","family":"Emmanouil","sequence":"additional","affiliation":[{"name":"School of Dentistry National and Kapodistrian University of Athens Athens Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,2,25]]},"reference":[{"issue":"3","key":"e_1_2_8_2_1","first-page":"200","article-title":"Prevalence and measurement of dental caries in young children","volume":"37","author":"Dye BA","year":"2015","journal-title":"Pediatr Dent"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.5005\/jp-journals-10005-1540"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(07)60031-2"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bdj.4814259"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.3389\/fped.2017.00157"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.3109\/00016355308993925"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034511422910"},{"key":"e_1_2_8_9_1","unstructured":"GeneCards.Human Gene Database ACTN gene.https:\/\/www.genecards.org\/cgi-bin\/carddisp.pl?gene=ACTN2. Accessed October 24 2019."},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0722.2010.00722.x"},{"key":"e_1_2_8_11_1","unstructured":"GeneCards.Human Gene Database MPPED2 gene.https:\/\/www.genecards.org\/cgi-bin\/carddisp.pl?gene=MPPED2. Accessed October 25 2019."},{"key":"e_1_2_8_12_1","unstructured":"MalaCards Human Disease Database.Aniridia 1 (AN1).https:\/\/www.malacards.org\/card\/aniridia_1. Accessed October 25 2019."},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034514534688"}],"container-title":["International Journal of Paediatric Dentistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fipd.12627","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ipd.12627","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/ipd.12627","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ipd.12627","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,6]],"date-time":"2023-09-06T11:18:08Z","timestamp":1693999088000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ipd.12627"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,2,25]]},"references-count":12,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2020,7]]}},"alternative-id":["10.1111\/ipd.12627"],"URL":"https:\/\/doi.org\/10.1111\/ipd.12627","archive":["Portico"],"relation":{},"ISSN":["0960-7439","1365-263X"],"issn-type":[{"value":"0960-7439","type":"print"},{"value":"1365-263X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,2,25]]},"assertion":[{"value":"2019-11-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-02-07","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-02-25","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}