{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T19:16:02Z","timestamp":1790190962726,"version":"4.1.0"},"reference-count":40,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2020,4,20]],"date-time":"2020-04-20T00:00:00Z","timestamp":1587340800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","award":["001"],"award-info":[{"award-number":["001"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004586","name":"Funda\u00e7\u00e3o Carlos Chagas Filho de Amparo \u00e0 Pesquisa do Estado do Rio de Janeiro","doi-asserted-by":"publisher","award":["E\u201026\/010.100992\/2018"],"award-info":[{"award-number":["E\u201026\/010.100992\/2018"]}],"id":[{"id":"10.13039\/501100004586","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004586","name":"Funda\u00e7\u00e3o Carlos Chagas Filho de Amparo \u00e0 Pesquisa do Estado do Rio de Janeiro","doi-asserted-by":"publisher","award":["E\u201026\/202.191\/2018"],"award-info":[{"award-number":["E\u201026\/202.191\/2018"]}],"id":[{"id":"10.13039\/501100004586","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Paed Dentistry"],"published-print":{"date-parts":[[2020,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Information about the functional and morphological consequences that occur following the premature loss of anterior teeth is still insufficient.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>To evaluate the consequences in children's speech and arch integrity following premature loss of primary anterior teeth compared to those without premature losses.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Electronic searches were performed based on the PECO criteria. Observational studies in children (P) who suffered premature loss or extraction of primary anterior teeth (E) compared to children presenting normal occlusion development (C) and the consequences to speech and dental arch perimeter (O) were included. Risk of bias and data extraction were performed. The meta\u2010analysis evaluated the influence of premature loss of primary anterior teeth in articulatory speech disorders (distortion, omission, and substitution) and space loss in the dental arches. Random\u2010 and fixed\u2010effect models were used, and heterogeneity was tested. The certainty of evidence was estimated using the GRADE approach.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>From a total of 2.234 studies, six studies were included in the qualitative synthesis, and four in speech disorders meta\u2010analysis. Despite it was not possible to perform space loss meta\u2010analysis due to the absence of available data, qualitative analysis showed that there was no space loss after premature loss of mandibular primary incisors; a space loss, however, could be observed in children who lost primary canines at an early stage of dental development. For speech disorders results, children who lost anterior tooth presented higher chance of suffering speech distortion, than children without tooth loss (OR 5.466 [1.689, 17.692] <jats:italic>P<\/jats:italic>\u00a0=\u00a0.005) with low certainty of evidence. On the other hand, there were no statistically differences between premature loss of primary anterior teeth and omission (OR (a) 1.157 [0.439, 3.049] <jats:italic>P<\/jats:italic>\u00a0=\u00a0.767 and (OR (b) 1.393 [0.434, 4.70] <jats:italic>P<\/jats:italic>\u00a0=\u00a0.577) or substitution (OR (a) 1.071 [0.581, 1.974] <jats:italic>P<\/jats:italic>\u00a0=\u00a0.827 and OR (b) 1.218 [0.686, 2.163] <jats:italic>P<\/jats:italic>\u00a0=\u00a0.5), both with very low certainty of evidence.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Premature loss of primary anterior teeth may affect children phonation causing speech distortion. Consequences of space loss to primary dental arch still need to be further studied. Despite the speech distortion results, included articles present low\u2010level evidence\u2010based quality, thus new studies should be performed.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ipd.12644","type":"journal-article","created":{"date-parts":[[2020,4,3]],"date-time":"2020-04-03T15:28:45Z","timestamp":1585927725000},"page":"687-712","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":56,"title":["Premature loss of primary anterior teeth and its consequences to primary dental arch and speech pattern: A systematic review and meta\u2010analysis"],"prefix":"10.1111","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5782-1203","authenticated-orcid":false,"given":"Patricia","family":"Nadelman","sequence":"first","affiliation":[{"name":"Department of Pediatric Dentistry and Orthodontics School of Dentistry Universidade Federal do Rio de Janeiro Rio de Janeiro RJ Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nat\u00e1lia","family":"Bedran","sequence":"additional","affiliation":[{"name":"Department of Pediatric Dentistry and Orthodontics School of Dentistry Universidade Federal do Rio de Janeiro Rio de Janeiro RJ Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3618-190X","authenticated-orcid":false,"given":"Marcela Bara\u00fana","family":"Magno","sequence":"additional","affiliation":[{"name":"Department of Pediatric Dentistry and Orthodontics School of Dentistry Universidade Federal do Rio de Janeiro Rio de Janeiro RJ Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7108-1117","authenticated-orcid":false,"given":"Daniele","family":"Masterson","sequence":"additional","affiliation":[{"name":"Central Library of the Health Science Center Universidade Federal do Rio de Janeiro Rio de Janeiro RJ Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7174-3846","authenticated-orcid":false,"given":"Amanda Cunha Regal","family":"de Castro","sequence":"additional","affiliation":[{"name":"Department of Pediatric Dentistry and Orthodontics School of Dentistry Universidade Federal do Rio de Janeiro Rio de Janeiro RJ Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1026-9401","authenticated-orcid":false,"given":"Lucianne Cople","family":"Maia","sequence":"additional","affiliation":[{"name":"Department of Pediatric Dentistry and Orthodontics School of Dentistry Universidade Federal do Rio de Janeiro Rio de Janeiro RJ Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,4,20]]},"reference":[{"key":"e_1_2_9_2_1","first-page":"753\u2013757\u2010760, 76","article-title":"Guidelines on the use of space maintainers following premature loss of primary teeth","volume":"63","author":"Brothwell DJ","year":"1997","journal-title":"J Can Dent Assoc"},{"key":"e_1_2_9_3_1","first-page":"171","volume-title":"Atlas of Orthodontics Principles","author":"Thurow RC","year":"1977"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.17796\/jcpd.26.1.d31684214173564k"},{"key":"e_1_2_9_5_1","first-page":"254","article-title":"The development of the permanent teeth","volume":"27","author":"Nolla C","year":"1960","journal-title":"J Dent Child"},{"key":"e_1_2_9_6_1","first-page":"189","article-title":"Early loss of deciduous molars in children assisted by the School of Dentistry of the University of Bahia","volume":"12","author":"Santos AGC","year":"2013","journal-title":"Odontol Cl\u00edn\u2010Cient"},{"key":"e_1_2_9_7_1","first-page":"173","article-title":"Premature loss of the maxillary primary incisors: effect on speech production","author":"Gable TO","year":"1995","journal-title":"J Dent Child"},{"key":"e_1_2_9_8_1","first-page":"295","article-title":"Mc Gorray SP. 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