{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T16:44:09Z","timestamp":1790181849548,"version":"4.1.0"},"reference-count":30,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2020,10,11]],"date-time":"2020-10-11T00:00:00Z","timestamp":1602374400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Paed Dentistry"],"published-print":{"date-parts":[[2021,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Oral mucositis (OM) is one of the main adverse effects of the chemotherapeutic agent methotrexate (MTX).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To evaluate the relationship of OM with MTX metabolism time and other toxicities in childhood, cancer patients receiving high\u2010dose of methotrexate (HD\u2010MTX).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>\n                      Seventy\u2010seven childhood patients receiving HD\u2010MTX for treatment of leukaemia, osteosarcoma or lymphoma were evaluated. MTX serum level,\n                      <jats:italic>hepatic<\/jats:italic>\n                      and renal function parameters, and presence and intensity of OM were analysed.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The patients were submitted to 255 cycles of chemotherapy. OM was diagnosed in 191 (74.9%) cycles. Of these, 119 (46.6%) presented ulcerative lesions. Lymphoma was associated with severe OM (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a0.01). OM was associated with higher serum levels of aspartate aminotransferase (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a0.006), alanine aminotransferase (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a0.04) and creatinine (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a0.008). Increase of one unit of total bilirubin and indirect bilirubin associated, respectively, with 11% and 39% higher prevalence of OM. For each increase of one unit of creatinine serum level, it was observed a 37% higher prevalence of OM in patients with lymphoma. No association was found between delayed excretion of MTX and OM development.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>OM is a prevalent complication of childhood cancer patients receiving HD\u2010MTX. Renal and hepatic toxicity could be considered risk factors for OM, especially in patients with lymphoma.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ipd.12718","type":"journal-article","created":{"date-parts":[[2020,8,28]],"date-time":"2020-08-28T09:56:09Z","timestamp":1598608569000},"page":"238-246","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Oral mucositis in childhood cancer patients receiving high\u2010dose methotrexate: Prevalence, relationship with other toxicities and methotrexate elimination"],"prefix":"10.1111","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3942-317X","authenticated-orcid":false,"given":"J\u00e9ssica Bert\u00e9","family":"Valer","sequence":"first","affiliation":[{"name":"Department of Oral Pathology and Oral Medicine School of Dentistry Federal University of Rio Grande do Sul  Porto Alegre Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8473-9424","authenticated-orcid":false,"given":"Marina","family":"Curra","sequence":"additional","affiliation":[{"name":"Department of Oral Pathology and Oral Medicine School of Dentistry Federal University of Rio Grande do Sul  Porto Alegre Brazil"},{"name":"School of Dentistry University of Caxias do Sul  Caxias do Sul RS Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8910-5815","authenticated-orcid":false,"given":"Amanda de Farias","family":"Gabriel","sequence":"additional","affiliation":[{"name":"Department of Oral Pathology and Oral Medicine School of Dentistry Federal University of Rio Grande do Sul  Porto Alegre Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0980-2272","authenticated-orcid":false,"given":"Tuany Rafaeli","family":"Schmidt","sequence":"additional","affiliation":[{"name":"Department of Oral Pathology and Oral Medicine School of Dentistry Federal University of Rio Grande do Sul  Porto Alegre Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6814-6773","authenticated-orcid":false,"given":"Maria Beatriz Cardoso","family":"Ferreira","sequence":"additional","affiliation":[{"name":"Full Professor of Pharmacology Invited Professor Department of Conservative Dentistry Federal University of Rio Grande do Sul  Porto Alegre Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafael","family":"Roesler","sequence":"additional","affiliation":[{"name":"Cancer and Neurobiology Laboratory Experimental Research Center Porto Alegre Clinical Hospital Federal University of Rio Grande do Sul  Porto Alegre Brazil"},{"name":"Children\u2019s Cancer Institute  Porto Alegre 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Incid\u00eancia Mortalidade e Morbidade Hospitalar por C\u00e2ncer em Crian\u00e7as. Adolescentes e Adultos Jovens no Brasil: Informa\u00e7\u00f5es dos Registros de C\u00e2ncer e do Sistema de Mortalidade.Rio de Janeiro Brazil:Instituto Nacional de C\u00e2ncer Jos\u00e9 Alencar Gomes da Silva INCA;2017."},{"key":"e_1_2_10_5_1","first-page":"1","article-title":"The influence of antineoplasic treatment on the weight of survivors of childhood cancer","volume":"401","author":"Teixeira JF","year":"2016","journal-title":"J Pediatr"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1124\/pr.118.016972"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.2015-0164"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.5045\/br.2016.51.1.50"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1080\/01635581.2017.1324995"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.27403"},{"key":"e_1_2_10_11_1","first-page":"11594","article-title":"CCND1 G870A polymorphism is associated with toxicity of methotrexate in childhood acute lymphoblastic leukemia","volume":"8","author":"Xue Y","year":"2015","journal-title":"Int J Clin Exp Pathol"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.17781"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-019-04848-4"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.5863\/1551-6776-17.4.340"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00280-016-3043-5"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/imj.14468"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10103-017-2314-7"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-011-1343-1"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-263X.2011.01113.x"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arcped.2019.05.012"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPH.0000000000000970"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.critrevonc.2019.07.003"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00431-017-3043-4"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-009-0618-2"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1080\/028418698429586"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.4317\/jced.51337"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-019-04890-2"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10103-019-02722-7"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.25305"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.3109\/10428194.2013.840780"},{"issue":"4","key":"e_1_2_10_31_1","first-page":"1070","article-title":"Chemotherapy related toxicity in childhood neoplasia","volume":"19","author":"Miron I","year":"2014","journal-title":"J Buon"}],"container-title":["International Journal of Paediatric Dentistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ipd.12718","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/ipd.12718","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ipd.12718","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T17:22:57Z","timestamp":1693588977000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ipd.12718"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,10,11]]},"references-count":30,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2021,3]]}},"alternative-id":["10.1111\/ipd.12718"],"URL":"https:\/\/doi.org\/10.1111\/ipd.12718","archive":["Portico"],"relation":{},"ISSN":["0960-7439","1365-263X"],"issn-type":[{"value":"0960-7439","type":"print"},{"value":"1365-263X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,10,11]]},"assertion":[{"value":"2020-04-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-07-06","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-10-11","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}