{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T12:54:43Z","timestamp":1769777683831,"version":"3.49.0"},"reference-count":24,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,10,11]],"date-time":"2020-10-11T00:00:00Z","timestamp":1602374400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Paed Dentistry"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Temporomandibular disorder (TMD) is a condition, in which multiple factors act synergistically to determine the outcome of the disorder.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>A systematic review and meta\u2010analysis was conducted to evaluate the association between genetic polymorphisms in catechol\u2010O\u2010methyltransferase (<jats:italic>COMT<\/jats:italic>) and TMD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Observational studies that investigated this association were included. The risk of bias and study quality were evaluated according to the Newcastle\u2010Ottawa tool. The meta\u2010analysis was performed for each polymorphism associated with TMD signs and symptoms.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 1903 articles were identified. Ten remained in the qualitative analysis: six were classified as low risk of bias and four with moderate risk of bias, and three were included in the meta\u2010analysis. The polymorphism rs6269, in the genotypic model (0.65; CI\u00a0=\u00a00.44\u20100.97; <jats:italic>P<\/jats:italic>\u00a0=\u00a0.04) and in the allelic model (0.73; CI\u00a0=\u00a00.54\u20100.98; <jats:italic>P<\/jats:italic>\u00a0=\u00a0.04), was associated with myofascial pain. The rs9332377 was associated with myofascial pain in the genotypic model (2.69; CI\u00a0=\u00a01.51\u20104.76; <jats:italic>P<\/jats:italic>\u00a0=\u00a0.0007) and in the allelic model (1.46; CI\u00a0=\u00a01.01\u20102.13; <jats:italic>P<\/jats:italic>\u00a0=\u00a0.05) and with painful TMD in the genotypic model (2.08; CI\u00a0=\u00a01.27\u20103.40; <jats:italic>P<\/jats:italic>\u00a0=\u00a0.004) and in the allelic model (1.34 CI\u00a0=\u00a00.98\u20101.82; <jats:italic>P<\/jats:italic>\u00a0=\u00a0.06).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The polymorphisms in <jats:italic>COMT<\/jats:italic> were significantly associated with TMD.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ipd.12721","type":"journal-article","created":{"date-parts":[[2020,9,23]],"date-time":"2020-09-23T00:57:50Z","timestamp":1600822670000},"page":"152-163","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Is catechol\u2010O\u2010methyltransferase gene associated with temporomandibular disorders? A systematic review and meta\u2010analysis"],"prefix":"10.1111","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8914-702X","authenticated-orcid":false,"given":"Jo\u00e3o Armando","family":"Brancher","sequence":"first","affiliation":[{"name":"School of Health Sciences Universidade Positivo Curitiba Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fernanda Mara de Paiva","family":"Bertoli","sequence":"additional","affiliation":[{"name":"School of Health Sciences Universidade Positivo Curitiba Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bruna","family":"Michels","sequence":"additional","affiliation":[{"name":"School of Health Sciences Universidade Positivo Curitiba Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aluh\u00ea","family":"Lopes\u2010Faturri","sequence":"additional","affiliation":[{"name":"Department of Stomatology Universidade Federal do Paran\u00e1 Curitiba 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