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Cross\u2010sectional observational studies on the prevalence of biopsied oral pediatric malignancies were included. The Newcastle\u2010Ottawa Scale assessed the quality of the included studies, and the GRADE approach evaluated the evidence certainty. The meta\u2010analysis prevalence was calculated using MedCalc\u00ae software, adopting a 95% confidence level (CI; random\u2010effect model).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Forty\u2010two studies were included in the meta\u2010analysis. Of the 64,522 biopsies, the prevalence of malignant lesions was 1.93% (n\u00a0=\u00a01,100; 95% CI\u00a0=\u00a01.21%\u20102.80%). Countries with a low socioeconomic profile showed the highest prevalence. The sample size did not influence the prevalence of oral malignancies, and unspecified lymphomas (12.08%; 95% CI\u00a0=\u00a05.73%\u201020.37%) and rhabdomyosarcoma (10.53%; 95% CI\u00a0=\u00a07.28%\u201014.30%) were the most common lesions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Oral malignant lesions biopsied in children and adolescents had a prevalence of &lt;3%, and lymphomas and sarcomas were the most prevalent lesions.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ipd.12765","type":"journal-article","created":{"date-parts":[[2020,12,2]],"date-time":"2020-12-02T04:49:16Z","timestamp":1606884556000},"page":"504-519","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Prevalence of malignant neoplastic oral lesions among children and adolescents: A systematic review and meta\u2010analysis"],"prefix":"10.1111","volume":"31","author":[{"given":"Dayrine Silveira","family":"de 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