{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T15:48:16Z","timestamp":1791215296234,"version":"4.1.0"},"reference-count":33,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2021,7,20]],"date-time":"2021-07-20T00:00:00Z","timestamp":1626739200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Paed Dentistry"],"published-print":{"date-parts":[[2022,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Oral mucositis (OM) is an important side effect related to allogeneic hematopoietic stem cell transplantation (allo\u2010HSCT), and it has been associated with a significative reduction of quality of life. A negative impact of OM in paediatric patients could result in increased use of parenteral feeding and opioids, longer periods of hospitalization, and a higher risk of systemic infection.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>To investigate the clinical features and clinical outcomes associated with OM development and severity in hematological cancer paediatric patients undergoing allo\u2010HSCT who underwent professional dental care (PDC) and photobiomodulation (PBM) as prophylactic treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Medical data and OM presentation were retrieved retrospectively from all patients younger than 18\u00a0years who received allo\u2010HSCT between 2013 and 2016. The incidence of OM was assessed and graded by two oral medicine specialists following the WHO guidelines, and it was correlated with clinical parameters.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Forty\u2010nine consecutive paediatric patients were included. OM was diagnosed in 73.5% of patients, and in 36.1% of patients, OM was classified as severe. Acute lymphoblastic leukemia as a primary diagnosis and the use of a myeloablative regimen were associated with OM development. The primary diagnosis and use of total body irradiation (TBI) were associated with aggressive OM. Neither the incidence nor the severity of OM affected the overall survival, whereas only the use of a myeloablative regimen and a high body mass index (BMI) were determinants of lower OM\u2010free survival rates.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>A myeloablative conditioning and a high BMI were observed to be independent prognostic determinants of a lower OMFS rate. The cluster analysis allowed us to outline patient profiles with greater susceptibility to the development and severity of oral mucositis, which seems to be a useful tool to determine the risk of OM in paediatric patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ipd.12850","type":"journal-article","created":{"date-parts":[[2021,6,11]],"date-time":"2021-06-11T14:39:26Z","timestamp":1623422366000},"page":"251-263","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Oral mucositis in paediatric cancer patients undergoing allogeneic hematopoietic stem cell transplantation preventively treated with professional dental care and photobiomodulation: Incidence and risk factors"],"prefix":"10.1111","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5666-8689","authenticated-orcid":false,"given":"Wanessa","family":"Miranda\u2010Silva","sequence":"first","affiliation":[{"name":"Instituto de Ensino e Pesquisa Hospital S\u00edrio\u2010Liban\u00eas  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felipe Paiva","family":"da Fonseca","sequence":"additional","affiliation":[{"name":"Department of Oral Surgery and Pathology School of Dentistry Universidade Federal de Minas Gerais  Belo Horizonte Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandra Araujo","family":"Gomes","sequence":"additional","affiliation":[{"name":"Bone Marrow Transplant Unit Hospital S\u00edrio\u2010Liban\u00eas  S\u00e3o Paulo Brazil"},{"name":"Pediatric Hematology\u2010Oncology Unit ITACI\/ICR\u2010HCFMUSP  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Beatriz Bechara","family":"Mafra","sequence":"additional","affiliation":[{"name":"Bone Marrow Transplant Unit Hospital S\u00edrio\u2010Liban\u00eas  S\u00e3o Paulo Brazil"},{"name":"Pediatric Hematology\u2010Oncology Unit ITACI\/ICR\u2010HCFMUSP  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vanderson","family":"Rocha","sequence":"additional","affiliation":[{"name":"Bone Marrow Transplant Unit Hospital S\u00edrio\u2010Liban\u00eas  S\u00e3o Paulo Brazil"},{"name":"Department of Hematology, Hemotherapy and Cell Therapy USP  S\u00e3o Paulo Brazil"},{"name":"Department of Hematology NHS\u2010BT University of Oxford  Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5196-7631","authenticated-orcid":false,"given":"Eduardo Rodrigues","family":"Fregnani","sequence":"additional","affiliation":[{"name":"Instituto de Ensino e Pesquisa Hospital S\u00edrio\u2010Liban\u00eas  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,7,20]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00431-017-3043-4"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/bmt.2010.184"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/petr.12094"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1089\/pho.2012.3327"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1089\/pho.2015.4021"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2004.05.147"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/hon.2050"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2015.10.022"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/CCO.0000000000000180"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/petr.12440"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1590\/0103-6440201802881"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-012-1620-7"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/ejh.13299"},{"key":"e_1_2_7_15_1","article-title":"Risk factors associated with the development of oral mucositis in pediatric oncology patients: Systematic review and meta\u2010analysis","volume":"03","author":"Farias GA","year":"2021","journal-title":"Oral Dis"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-011-1202-0"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-012-1684-4"},{"key":"e_1_2_7_18_1","first-page":"1","article-title":"MASCC\/ISOO clinical practice guidelines for the management of mucositis: sub\u2010analysis of current interventions for the management of oral mucositis in pediatric cancer patients","volume":"11","author":"Miranda\u2010Silva W","year":"2020","journal-title":"Support Care Cancer"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.3390\/dj8030087"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/scd.12525"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1089\/pho.2015.3954"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc1318"},{"issue":"00","key":"e_1_2_7_23_1","first-page":"1","article-title":"The prevalence and investigation of risk factors of oral mucositis in a pediatric oncology inpatient population; a prospective study","volume":"00","author":"Allen G","year":"2017","journal-title":"J Pediatr Hematol Oncol"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-014-2190-7"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10103-017-2314-7"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1754-4505.1998.tb01738.x"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-019-04848-4"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1590\/S1517-74912003000200009"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/ipd.12090"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.27098"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm7050090"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10103-017-2266-y"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1177\/1043454203259947"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.27403"}],"container-title":["International Journal of Paediatric Dentistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ipd.12850","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/ipd.12850","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ipd.12850","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,27]],"date-time":"2023-08-27T06:06:32Z","timestamp":1693116392000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ipd.12850"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,7,20]]},"references-count":33,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2022,3]]}},"alternative-id":["10.1111\/ipd.12850"],"URL":"https:\/\/doi.org\/10.1111\/ipd.12850","archive":["Portico"],"relation":{},"ISSN":["0960-7439","1365-263X"],"issn-type":[{"value":"0960-7439","type":"print"},{"value":"1365-263X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,7,20]]},"assertion":[{"value":"2021-02-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-05-28","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-07-20","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}