{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T05:52:55Z","timestamp":1792043575386,"version":"4.4.0"},"reference-count":30,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2022,2,6]],"date-time":"2022-02-06T00:00:00Z","timestamp":1644105600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Paed Dentistry"],"published-print":{"date-parts":[[2022,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To conduct a systematic review and to evaluate the clinical parameters for periodontal diseases in individuals with cleft lip and\/or palate (CL\/P).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>The authors searched six indexed databases without any linguistic limitation through July 2021. The eligibility criteria were observational studies that compared the periodontal clinical measures of individuals with CL\/P to those without CL\/P. A meta\u2010analysis was conducted using random\u2010effects models with inverse variance weighting.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The literature search generated 1277 records, and 40 full\u2010text articles were reviewed. Twenty\u2010three studies comprising 3235 individuals from four continents fulfilled our selection criteria. The meta\u2010analysis revealed a significant difference in mean plaque index scores (MD\u00a0=\u00a00.31, 95% CI\u00a0=\u00a00.22, 0.41), gingival index scores (MD\u00a0=\u00a00.50, 95% CI\u00a0=\u00a00.24, 0.77), and periodontal pocket depth (MD\u00a0=\u00a00.64, 95% CI\u00a0=\u00a00.12, 1.16) between individuals with and without CL\/P. A slight increase in clinical attachment loss was detected among individuals with CL\/P; however, such an increase may have little clinical significance.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>As age is positively related to periodontal disease progression, and individuals with CL\/P are more likely to present with more plaque accumulation and gingival inflammation, clinicians should reinforce preventive dental care from an early age.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ipd.12934","type":"journal-article","created":{"date-parts":[[2021,10,9]],"date-time":"2021-10-09T12:10:37Z","timestamp":1633781437000},"page":"558-575","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Association between oral clefts and periodontal clinical measures: A 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USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christy","family":"McKinney","sequence":"additional","affiliation":[{"name":"Division of Craniofacial Medicine and Seattle Children\u2019s Research Institute Department of Pediatrics University of Washington  Seattle Washington USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cynthia","family":"Wong","sequence":"additional","affiliation":[{"name":"Division of Pediatric Dentistry Eastman Institute for Oral Health University of Rochester  Rochester New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa","family":"DeLucia","sequence":"additional","affiliation":[{"name":"Division of Pediatric Dentistry Eastman Institute for Oral Health University of Rochester  Rochester New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ritu","family":"Shah","sequence":"additional","affiliation":[{"name":"Division of Pediatric Dentistry Eastman Institute for Oral 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