{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T09:46:43Z","timestamp":1771667203726,"version":"3.50.1"},"reference-count":29,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2022,4,2]],"date-time":"2022-04-02T00:00:00Z","timestamp":1648857600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Paed Dentistry"],"published-print":{"date-parts":[[2022,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Mucopolysaccharidoses (MPS) are a group of rare metabolic diseases characterized by a wide spectrum of symptoms including progressive condylar resorption.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>The aim of this study was to quantify the severity of condylar involvement in MPS I individuals in comparison with a group of non\u2010MPS individuals and to describe how condylar changes may vary among the different types of MPS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Fifty panoramic radiographs of MPS patients (13.4\u00a0\u00b1\u00a06.2\u00a0years) with MPS I (<jats:italic>n<\/jats:italic>\u00a0=\u00a014), MPS II (<jats:italic>n<\/jats:italic>\u00a0=\u00a02), MPS IV (<jats:italic>n<\/jats:italic>\u00a0=\u00a08) and MPS VI (<jats:italic>n<\/jats:italic>\u00a0=\u00a02) were compared with forty panoramic radiographs of non\u2010MPS individuals. The severity of condylar resorption was evaluated using a qualitative score (grades 0\u20133) and using the ratio of condylar height to ramus height (CH: RH).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>All MPS I and VI individuals showed pronounced bilateral degenerative condylar resorption. In contrast, individuals with MPS II and IV exhibited heterogeneous findings. The quantification of condylar height to ramus height revealed that CH: RH was significantly decreased in MPS I as compared to that of non\u2010MPS individuals (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001). In contrast, the CH: RH ratios of MPS II and IV showed great variability.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Mucopolysaccharidoses subtypes differ with regard to the severity of condylar resorption.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ipd.12952","type":"journal-article","created":{"date-parts":[[2021,12,30]],"date-time":"2021-12-30T08:18:57Z","timestamp":1640852337000},"page":"737-744","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Mandibular condyle morphology among patients with mucopolysaccharidosis: An observational study of panoramic radiographs"],"prefix":"10.1111","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2034-0793","authenticated-orcid":false,"given":"Carmen Ulrike","family":"Schmid\u2010Herrmann","sequence":"first","affiliation":[{"name":"Department of Orthodontics Center for Dental and Oral Medicine University Medical Center Hamburg\u2010Eppendorf  Hamburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicole Maria","family":"Muschol","sequence":"additional","affiliation":[{"name":"Department of Pediatrics University Medical Center Hamburg\u2010Eppendorf  Hamburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vera Ulrike","family":"Fuhrmann","sequence":"additional","affiliation":[{"name":"Department of Orthodontics Center for Dental and Oral Medicine University Medical Center Hamburg\u2010Eppendorf  Hamburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anja Friederike","family":"Koehn","sequence":"additional","affiliation":[{"name":"Department of Pediatrics University Medical Center Hamburg\u2010Eppendorf  Hamburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susanne","family":"Lezius","sequence":"additional","affiliation":[{"name":"Department of Medical Biometry and Epidemiology University Medical Center Hamburg\u2010Eppendorf  Hamburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B\u00e4rbel","family":"Kahl\u2010Nieke","sequence":"additional","affiliation":[{"name":"Department of Orthodontics Center for Dental and Oral Medicine University Medical Center Hamburg\u2010Eppendorf  Hamburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Till","family":"Koehne","sequence":"additional","affiliation":[{"name":"Department of Orthodontics University Medical Center Leipzig  Leipzig Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,4,2]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymgme.2018.01.003"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13023-016-0503-2"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10545-005-0112-z"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/1750-1172-6-55"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1597\/13-204"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11325-019-01900-9"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/8904_2011_46"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oooo.2015.08.009"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tripleo.2007.02.015"},{"issue":"3","key":"e_1_2_10_11_1","first-page":"286","article-title":"Two cases of Hunter's syndrome\u2013the anaesthetic and operative difficulties in oral surgery","volume":"10","author":"Hopkins R","year":"1973","journal-title":"Br J Oral Surg"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10545-013-9645-8"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-263X.2010.01055.x"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/0030-4220(75)90200-5"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00784-017-2240-x"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joms.2014.07.006"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/0030-4220(93)90244-X"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1259\/dmfr.21.1.1397452"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.4103\/0976-237X.94554"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/0030-4220(90)90181-Q"},{"issue":"2","key":"e_1_2_10_21_1","first-page":"98","article-title":"Hunter's syndrome and oral manifestations: a review","volume":"17","author":"Downs AT","year":"1995","journal-title":"Pediatr Dent"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-263x.1999.00127.x"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tripleo.2005.06.023"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oooo.2013.04.021"},{"issue":"3","key":"e_1_2_10_25_1","first-page":"e32","article-title":"Oral and systemic manifestations of mucopolysaccharidosis type VI: a report of seven cases","volume":"43","author":"Almeida\u2010Barros RQ","year":"2012","journal-title":"Quintessence Int"},{"issue":"4","key":"e_1_2_10_26_1","first-page":"221","article-title":"The forgotten joint \u2013 Das Kiefergelenk bei Juveniler Idiopathischer Arthritis (JIA)","volume":"45","author":"Kahl\u2010Nieke B","year":"2013","journal-title":"Inf Orthod Kieferorthop"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.3109\/00016359409096375"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/0030-4220(89)90279-X"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.2353\/ajpath.2008.070564"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymgme.2014.12.001"}],"container-title":["International Journal of Paediatric Dentistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ipd.12952","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/ipd.12952","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ipd.12952","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,22]],"date-time":"2023-08-22T17:58:18Z","timestamp":1692727098000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ipd.12952"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,4,2]]},"references-count":29,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2022,9]]}},"alternative-id":["10.1111\/ipd.12952"],"URL":"https:\/\/doi.org\/10.1111\/ipd.12952","archive":["Portico"],"relation":{},"ISSN":["0960-7439","1365-263X"],"issn-type":[{"value":"0960-7439","type":"print"},{"value":"1365-263X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,4,2]]},"assertion":[{"value":"2021-01-31","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-11-16","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-04-02","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}