{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T00:20:45Z","timestamp":1792023645029,"version":"4.4.0"},"reference-count":41,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2023,6,14]],"date-time":"2023-06-14T00:00:00Z","timestamp":1686700800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Paed Dentistry"],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Dental caries is the most common oral disease worldwide, and it is estimated to affect 2.3 billion people, with at least 530 million of them being schoolchildren with decayed primary teeth. This condition can rapidly evolve into irreversible pulp inflammation and pulp necrosis and thus requiring endodontic intervention. Photodynamic therapy (PDT) is a supplementary method to conventional pulpectomy and is used to improve the protocol used for disinfection.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>The main objective of this study was to evaluate through a systematic review the efficacy of supplementary PDT on the pulpectomy of primary teeth. This review was registered a priori on the PROSPERO database (CRD42022310581).<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Two independent and blinded reviewers carried out a comprehensive search in five databases: PubMed, Cochrane, Scopus, Embase, and Web of Science. Eligible studies were randomized and nonrandomized clinical trials that evaluated in vivo microbiological load or clinical outcomes after using supplementary PDT in infected primary teeth.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>After the selection process, four studies met the inclusion criteria and were included in this study. Data regarding the sample characteristics and PDT protocols were retrieved. All included trials used phenothiazinium salts as photosensitizer agents. Only one study observed a significant difference in the in vivo microbiological load reduction outcome when performing PDT on primary teeth. The remaining studies all discussed the possible benefits of this intervention; however, none observed a significant difference in this outcome.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In this systematic review, moderate\u2010to\u2010low certainty of the available evidence was observed, and thus, no significant conclusions can be drawn from the findings.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ipd.13088","type":"journal-article","created":{"date-parts":[[2023,5,17]],"date-time":"2023-05-17T14:04:02Z","timestamp":1684332242000},"page":"114-124","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Photodynamic therapy in the root canal treatment of primary teeth: A systematic review of clinical trials"],"prefix":"10.1111","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2893-1416","authenticated-orcid":false,"given":"Lucas Peixoto de","family":"Ara\u00fajo","sequence":"first","affiliation":[{"name":"Department of Restorative Dentistry, Division of Endodontics, Piracicaba Dental School State University of Campinas (UNICAMP)  Piracicaba Brazil"},{"name":"School of Dentistry Catholic University of Pelotas (UCPel)  Pelotas Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6271-0858","authenticated-orcid":false,"given":"Leandro Bueno","family":"Gobbo","sequence":"additional","affiliation":[{"name":"Department of Restorative Dentistry, Division of Endodontics, Piracicaba Dental School State University of Campinas (UNICAMP)  Piracicaba Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9580-1833","authenticated-orcid":false,"given":"Tamares Andrade da","family":"Silva","sequence":"additional","affiliation":[{"name":"Department of Restorative Dentistry, Division of Endodontics, Piracicaba Dental School State University of Campinas (UNICAMP)  Piracicaba Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wellington Luiz de Oliveira da","family":"Rosa","sequence":"additional","affiliation":[{"name":"Graduate Program in Dentistry, School of Dentistry Federal University of Pelotas (UFPEL)  Pelotas Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5874-9247","authenticated-orcid":false,"given":"Jos\u00e9 Fl\u00e1vio Affonso de","family":"Almeida","sequence":"additional","affiliation":[{"name":"Department of Restorative Dentistry, Division of Endodontics, Piracicaba Dental School State University of Campinas (UNICAMP)  Piracicaba Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8449-0646","authenticated-orcid":false,"given":"Brenda P. 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