{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T20:29:12Z","timestamp":1785875352468,"version":"3.56.0"},"reference-count":36,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100011544","name":"College of Dental Medicine, Columbia University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100011544","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Paed Dentistry"],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Children with neurodevelopmental disorders (NDDs) often have poor oral health and dental abnormalities. An increasing number of genes have been associated with neurodevelopmental conditions affecting the oral cavity, but the specific dental features associated with many genes remain unknown.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>To report the types and frequencies of dental manifestations in children with neurodevelopmental conditions of known genetic cause.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>A 30\u2010question survey assesing ectodermal and dental features was administered through Simons Searchlight, with which formed a recontactable cohort of individuals with genetic NDDs often associated with autism spectrum disorder (ASD).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Data were collected from a largely paediatric population with 620 affected individuals across 39 genetic conditions and 145 unaffected siblings without NDDs for comparison. Drooling, difficulty accessing dental care, late primary teeth eruption, abnormal primary and permanent teeth formation, misshapen nails, and hair loss were more frequent in individuals with NDDs. Additionally, we evidenced an association between three new pathogenic gene variant\/oral manifestation pairs: <jats:italic>CSNK2A1<\/jats:italic>\/unusual primary teeth, <jats:italic>DYRK1A<\/jats:italic>\/late primary teeth eruption, and <jats:italic>PPP2R5D<\/jats:italic>\/sialorrhea.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our results demonstrate that genetic NDDs caused by mutations in <jats:italic>CSNK2A1<\/jats:italic>, <jats:italic>DYRK1A<\/jats:italic>, and <jats:italic>PP2R5D<\/jats:italic> are associated with unique dental manifestations, and knowledge of these features can be helpful to personalize dental care.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ipd.13116","type":"journal-article","created":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T11:08:09Z","timestamp":1693566489000},"page":"145-152","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Caregiver\u2010reported 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