{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T14:37:45Z","timestamp":1787063865662,"version":"build-2736575974"},"reference-count":30,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,10,13]],"date-time":"2023-10-13T00:00:00Z","timestamp":1697155200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Paed Dentistry"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Mineralization\u2010promoting peptide\u20103 (MPP3) is a new biomimetic remineralization agent.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To assess the remineralization efficiency of MPP3, either alone or in combination with fluoride gel.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>\n                      The samples were divided into four groups: control, 1.23% fluoride gel, 10% MPP3 gel, and 1.23% fluoride gel\u2009+\u200910% MPP3. Following the application of remineralization agents (4\u2009min), the samples remained in a pH\u2010cycling model (37\u00b0C, 4\u2009weeks). Microhardness, microcomputed tomography (micro\u2010CT), polarized light microscopy (PLM), and field emission scanning electron microscopy (FE\u2010SEM) analysis were conducted. RM\u2010ANOVA, one\u2010way ANOVA, and intraclass correlation coefficient (ICC) were used for statistical analysis, and a significance level of\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u2009.05 was employed.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Mineralization\u2010promoting peptide 3 and fluoride gel\u2009+\u2009MPP3 increased the microhardness of the enamel compared with initial values in each group (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u2009.05). Mineralization\u2010promoting peptide 3 successfully maintained the mineral density of enamel, although the cariogenic pH\u2010cycling and PLM results indicated that the lesion depth (\u03bcm) was significantly lower in the fluoride gel\u2009+\u2009MPP3 group (27.0336\u2009\u00b1\u200912.53650) than in the control group (37.3907\u2009\u00b1\u200912.76002,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u2009.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The combined use of MPP3 with fluoride gel enhanced the caries\u2010protective and mineralization\u2010promoting effects of fluoride. Mineralization\u2010promoting peptide 3 may be a potential agent that can be employed to improve the physical properties of enamel.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ipd.13126","type":"journal-article","created":{"date-parts":[[2023,10,14]],"date-time":"2023-10-14T02:21:28Z","timestamp":1697250088000},"page":"256-266","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["In vitro caries\u2010preventive effect of a mineralization\u2010promoting peptide combined with fluoride gel on sound primary teeth"],"prefix":"10.1111","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1638-8383","authenticated-orcid":false,"given":"Merve","family":"Ya\u015far","sequence":"first","affiliation":[{"name":"Department of Pediatric Dentistry, Faculty of Gulhane Dental Medicine University of Health Sciences  Ankara 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Beyazit University  Ankara Turkey"},{"name":"MERLAB Application and Research Center Ankara Yildirim Beyazit University  Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6768-0176","authenticated-orcid":false,"given":"Kaan","family":"Orhan","sequence":"additional","affiliation":[{"name":"Department of Dentomaxillofacial Radiology Ankara University Faculty of Dentistry  Ankara 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