{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,18]],"date-time":"2026-04-18T14:23:45Z","timestamp":1776522225699,"version":"3.51.2"},"reference-count":34,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,3,21]],"date-time":"2024-03-21T00:00:00Z","timestamp":1710979200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100016028","name":"Ag\u00e8ncia Valenciana de la Innovaci\u00f3","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100016028","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003359","name":"Generalitat Valenciana","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003359","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Paed Dentistry"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Halitosis in children implies psychosocial repercussions. Risk factors associated with this condition are unclear, and detection methods are inaccurate.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>To quantify the levels of sulfur\u2010like compounds in children with asthma and healthy children from a novel validated assay, and to establish the risk factors related to halitosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>One hundred and twenty\u2010eight individuals (63 healthy and 65 asthmatic) from 3 to 17\u2009years of age were tested using a passive colorimetric sensor to measure the levels of sulfur\u2010like compounds in breath and saliva. Information was collected on oral hygiene habits, gingival and dental health, breathing type, and dental malocclusion.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The mean values of hydrogen sulfide were 4.0\u2009\u00b1\u20096.8 and 19.7\u2009\u00b1\u200912.2 ppbv (parts per billion in volume) in the control and asthmatic groups, respectively (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001). The presence of higher concentrations of sulfur compounds was significantly associated (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.05) with the presence of gingival inflammation, tongue coating, dental plaque, mouth breathing, hypomineralization, age, tongue brushing, and the use of dental floss.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The level of sulfur in breath and saliva was significantly higher in patients with asthma. These results can serve as a precedent to raise awareness among paediatricians and parents about oral hygiene care in children and adolescents.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ipd.13178","type":"journal-article","created":{"date-parts":[[2024,3,22]],"date-time":"2024-03-22T03:58:30Z","timestamp":1711079910000},"page":"782-789","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Volatile sulfur compounds in asthmatic children and adolescents: A cross\u2010sectional study in breath and saliva"],"prefix":"10.1111","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2992-1335","authenticated-orcid":false,"given":"Cindy","family":"Buj\u2010Acosta","sequence":"first","affiliation":[{"name":"Department of Stomatology University of Valencia  Valencia Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ver\u00f3nica","family":"Garc\u00eda\u2010Sanz","sequence":"additional","affiliation":[{"name":"Department of Stomatology University of Valencia  Valencia Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lusine","family":"Hakobyan","sequence":"additional","affiliation":[{"name":"MINTOTA Research Group, Department of Analytical Chemistry University of Valencia  Valencia Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Beatriz","family":"Tarazona\u2010\u00c1lvarez","sequence":"additional","affiliation":[{"name":"Department of Stomatology University of Valencia  Valencia Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carmen","family":"Molins\u2010Legua","sequence":"additional","affiliation":[{"name":"MINTOTA Research Group, Department of Analytical Chemistry University of Valencia  Valencia Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0980-8298","authenticated-orcid":false,"given":"Pilar","family":"Campins\u2010Falc\u00f3","sequence":"additional","affiliation":[{"name":"MINTOTA Research Group, Department of Analytical Chemistry University of Valencia  Valencia Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4137-5808","authenticated-orcid":false,"given":"Vanessa","family":"Paredes\u2010Gallardo","sequence":"additional","affiliation":[{"name":"Department of Stomatology University of Valencia  Valencia Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miguel","family":"Tortajada\u2010Girb\u00e9s","sequence":"additional","affiliation":[{"name":"Department of Pediatrics University of Valencia  Valencia Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,3,21]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1601-5037.2003.00056.x"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-9969(08)70002-5"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0030-4220(72)90271-X"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1977.48.1.13"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-302X.1990.tb00645.x"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003-9969(71)90062-8"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1991.62.8.487"},{"key":"e_1_2_12_9_1","first-page":"1","article-title":"Diagnostic technique for assessing halitosis origin using oral and nasal organoleptic tests, including safety measures post Covid\u201019","volume":"2","author":"Conceicao M","year":"2020","journal-title":"J Dent Oral Sci"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/adj.12725"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.5005\/jp-journals-10024-3017"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1088\/1752-7155\/8\/1\/017103"},{"issue":"4","key":"e_1_2_12_13_1","first-page":"274","article-title":"Dental health, halitosis, and mouth breathing in 10\u2010to\u201015\u2010year\u2010old children: a potential connection","volume":"20","author":"Alquitami J","year":"2019","journal-title":"Eur J Paediatr Dent"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40368-014-0109-0"},{"issue":"3","key":"e_1_2_12_15_1","first-page":"173","article-title":"Prevalence of breath malodour in 7\u201311\u2010year\u2010old children living in Middle Anatolia, Turkey","volume":"25","author":"Nal\u00e7aci R","year":"2008","journal-title":"Community Dent Health"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/odi.12210"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bdj.2016.220"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1984.tb00841.x"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1021\/acssensors.9b01019"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1590\/S1807-59322011000600003"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-0825.2005.01094.x"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0140214"},{"issue":"6","key":"e_1_2_12_23_1","first-page":"983","article-title":"Analysis of volatile sulfur compounds production of oral cavity in preschool children and influencing factors","volume":"47","author":"Zhang Q","year":"2015","journal-title":"Beijing Da Xue Xue Bao Yi Xue Ban"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/idh.12077"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.17796\/jcpd.28.4.xp213r6534322m58"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1088\/1752-7163\/aafc6f"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(99)70460-9"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12903-016-0297-6"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1442-200X.2003.01804.x"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1746-1561.2010.00512.x"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.3109\/00016357.2011.634834"},{"key":"e_1_2_12_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0528.2009.00510.x"},{"key":"e_1_2_12_33_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0722.2001.00047.x"},{"key":"e_1_2_12_34_1","first-page":"137","article-title":"Inhaler medicament effects on saliva and plaque pH in asthmatic children","volume":"22","author":"Kargul B","year":"1998","journal-title":"J Clin Pediatr Dent"},{"key":"e_1_2_12_35_1","first-page":"382","article-title":"A controlled study of risk factors for enamel hypoplasia in the permanent dentition","volume":"31","author":"Ford D","year":"2009","journal-title":"Pediatr Dent"}],"container-title":["International Journal of Paediatric Dentistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ipd.13178","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,19]],"date-time":"2024-10-19T05:44:08Z","timestamp":1729316648000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ipd.13178"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3,21]]},"references-count":34,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2024,11]]}},"alternative-id":["10.1111\/ipd.13178"],"URL":"https:\/\/doi.org\/10.1111\/ipd.13178","archive":["Portico"],"relation":{},"ISSN":["0960-7439","1365-263X"],"issn-type":[{"value":"0960-7439","type":"print"},{"value":"1365-263X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,3,21]]},"assertion":[{"value":"2023-10-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-02-28","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-03-21","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}