{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T17:10:18Z","timestamp":1789578618166,"version":"build-2803163510"},"reference-count":39,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,7,16]],"date-time":"2024-07-16T00:00:00Z","timestamp":1721088000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Paed Dentistry"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Pain and anxiety can be considerable obstacles while treating paediatric dental patients. Moderate sedation is needed to treat uncooperative patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>This study aimed to compare the effectiveness of buccal administration of dexmedetomidine\u2013ketamine combination versus dexmedetomidine.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Fifty\u2010six uncooperative children were randomly assigned into two groups: Group I received buccal dexmedetomidine (2\u2009\u03bcg\/kg) and ketamine (2\u2009mg\/kg) (DEX\u2013KET), whereas Group II received buccal dexmedetomidine (4\u2009\u03bcg\/kg) (DEX). The effects of drugs were evaluated based on changes in vital signs, onset and duration of sedation, sedation level, analgesia, ease of treatment and procedural adverse effects.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There were no significant differences in vital signs or sedation onset between the two groups. DEX\u2013KET group showed shorter recovery time than DEX group (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.0001). There were no statistically significant differences between both groups regarding sedation level at optimum sedation and during operative procedure (<jats:italic>p<\/jats:italic>\u2009=\u2009.064, <jats:italic>p<\/jats:italic>\u2009=\u2009.069 respectively). The ease of treatment was significantly better in DEX\u2013KET group than in DEX group (<jats:italic>p<\/jats:italic>\u2009=\u2009.048). Procedural side effects and analgesic effects of the sedative drugs were comparable between both groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The combination of dexmedetomidine and ketamine delivered buccally provided a better method of delivering care to uncooperative children with more rapid recovery than dexmedetomidine.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ipd.13238","type":"journal-article","created":{"date-parts":[[2024,7,16]],"date-time":"2024-07-16T09:31:42Z","timestamp":1721122302000},"page":"359-368","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Effectiveness of buccal administration of dexmedetomidine and ketamine combination in paediatric dental sedation: A randomized controlled clinical trial"],"prefix":"10.1111","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-9661-8650","authenticated-orcid":false,"given":"Sara 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