{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:52:40Z","timestamp":1787014360067,"version":"build-2736575974"},"reference-count":35,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,3,7]],"date-time":"2025-03-07T00:00:00Z","timestamp":1741305600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100012151","name":"Sanming Project of Medicine in Shenzen Municipality","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012151","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Paed Dentistry"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To assess the prevalence and risk factors of chemotherapy\u2010induced oral mucositis in 470 children with acute lymphoblastic leukemia in China, focusing on treatment\u2010related risk factors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This cross\u2010sectional study included 470 children diagnosed with acute lymphoblastic leukemia in China from January 2020 to July 2022. Data were collected from electronic medical records, field investigations, and telephone follow\u2010ups, covering sociodemographic characteristics, nutritional status, disease and treatment history, and microbiological factors. Univariate and multivariate logistic analyses were used to evaluate the association between the occurrence and severity of chemotherapy\u2010induced oral mucositis and these variables.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The prevalence of chemotherapy\u2010induced oral mucositis was 45.1%. Significant risk factors included receiving more than five chemotherapy cycles (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), carrying HSV\u20101 (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.016), infection with\n                      <jats:styled-content style=\"fixed-case\">\n                        <jats:italic>Candida albicans<\/jats:italic>\n                      <\/jats:styled-content>\n                      (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.012), undergoing chemotherapy with specific drugs containing methotrexate\/daunorubicin\/cytarabine (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), having a high clinical risk stratification (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.002), and being over 6\u2009years old (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.002). The severity of chemotherapy\u2010induced oral mucositis was associated with consolidation and intensification period (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.001) and B\u2010cell immune stratification (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The prevalence of chemotherapy\u2010induced oral mucositis in children with acute lymphoblastic leukemia is relatively high. It emphasizes the importance of clinical medical staff paying attention to this issue and adopting targeted interventions to reduce the prevalence of oral mucositis in this patient population.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ipd.13303","type":"journal-article","created":{"date-parts":[[2025,3,11]],"date-time":"2025-03-11T20:54:55Z","timestamp":1741726495000},"page":"888-897","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Prevalence and Risk Factors of Chemotherapy\u2010Induced Oral Mucositis in 470 Children With Acute Lymphoblastic Leukemia"],"prefix":"10.1111","volume":"35","author":[{"given":"Xiaofeng","family":"He","sequence":"first","affiliation":[{"name":"Southern Medical University School of Nursing  Guang Dong China"},{"name":"The First Affiliated Hospital of University of South China  Hu Nan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-0097-039X","authenticated-orcid":false,"given":"Xinwen","family":"Rong","sequence":"additional","affiliation":[{"name":"Southern Medical University School of Nursing  Guang Dong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weijie","family":"Wang","sequence":"additional","affiliation":[{"name":"Southern Medical University School of Nursing  Guang Dong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lichan","family":"Liang","sequence":"additional","affiliation":[{"name":"Department of Pediatric, Zhu Jiang Hospital Southern Medical University  Guang Dong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaomei","family":"Liao","sequence":"additional","affiliation":[{"name":"Department of Pediatric, Zhu Jiang Hospital Southern Medical University  Guang Dong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaying","family":"Huang","sequence":"additional","affiliation":[{"name":"Southern Medical University School of Nursing  Guang Dong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Zhang","sequence":"additional","affiliation":[{"name":"Southern Medical University School of Nursing  Guang Dong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenting","family":"Zhu","sequence":"additional","affiliation":[{"name":"Southern Medical University School of Nursing  Guang Dong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weifei","family":"Liu","sequence":"additional","affiliation":[{"name":"Southern Medical University School of Nursing  Guang Dong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Shi","sequence":"additional","affiliation":[{"name":"Southern Medical University School of Nursing  Guang Dong China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,3,7]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(17)30186-9"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(22)01541\u20100"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21219"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/6637503"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.5863\/1551\u20106776\u201017.4.340"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/ipd.12718"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40368\u2010022\u201000727\u20105"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00520\u2010011\u20101343\u20101"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13046\u2010020\u201001715\u20107"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1080\/24694193.2020.1727065"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.16821\/j.cnki.hsjx.2023.11.008"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.5414\/cpp46584"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601\u20100825.2008.01468.x"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.3109\/08880018.2015.1034819"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sjdr.2016.10.004"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1080\/24694193.2019.1577926"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2023.1096529"},{"issue":"2","key":"e_1_2_10_19_1","first-page":"132","article-title":"Oral Diseases in Children With Acute Lymphoblastic Leukemia With Chemotherapy Treatment","volume":"56","author":"Ju\u00e1rez\u2010L\u00f3pez M. 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